Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204146241> ?p ?o ?g. }
- W3204146241 abstract "Cohesin organizes the genome by forming intra-chromosomal loops and inter-sister chromatid linkages. During gamete formation by meiosis, chromosomes are reshaped to support crossover recombination and two consecutive rounds of chromosome segregation. Here we show that Eco1 acetyltransferase positions both chromatin loops and sister chromatid cohesion to organize meiotic chromosomes into functional domains in budding yeast. Eco1 acetylates the Smc3 cohesin subunit in meiotic S phase to establish chromatin boundaries, independently of DNA replication. Boundary formation by Eco1 is critical for prophase exit and for the maintenance of cohesion until meiosis II, but is independent of the ability of Eco1 to antagonize the cohesin-release factor, Wpl1. Conversely, prevention of cohesin release by Wpl1 is essential for centromeric cohesion, kinetochore monoorientation and co-segregation of sister chromatids in meiosis I. Our findings establish Eco1 as a key determinant of chromatin boundaries and cohesion positioning, revealing how local chromosome structuring directs genome transmission into gametes." @default.
- W3204146241 created "2021-10-11" @default.
- W3204146241 creator A5009871990 @default.
- W3204146241 creator A5011705834 @default.
- W3204146241 creator A5013561763 @default.
- W3204146241 creator A5089234415 @default.
- W3204146241 date "2021-09-25" @default.
- W3204146241 modified "2023-10-15" @default.
- W3204146241 title "Eco1-dependent cohesin acetylation anchors chromatin loops and cohesion to define functional meiotic chromosome domains" @default.
- W3204146241 cites W1540274642 @default.
- W3204146241 cites W1943612516 @default.
- W3204146241 cites W1952201404 @default.
- W3204146241 cites W1970597357 @default.
- W3204146241 cites W1972204893 @default.
- W3204146241 cites W1972307085 @default.
- W3204146241 cites W1978696228 @default.
- W3204146241 cites W1979162302 @default.
- W3204146241 cites W1979298341 @default.
- W3204146241 cites W1982367970 @default.
- W3204146241 cites W1982553328 @default.
- W3204146241 cites W1983712701 @default.
- W3204146241 cites W2008553523 @default.
- W3204146241 cites W2010115820 @default.
- W3204146241 cites W2010442490 @default.
- W3204146241 cites W2012867104 @default.
- W3204146241 cites W2021859989 @default.
- W3204146241 cites W2022753514 @default.
- W3204146241 cites W2037569904 @default.
- W3204146241 cites W2045710299 @default.
- W3204146241 cites W2052648473 @default.
- W3204146241 cites W2078427400 @default.
- W3204146241 cites W2080831216 @default.
- W3204146241 cites W2082162397 @default.
- W3204146241 cites W2095769598 @default.
- W3204146241 cites W2096525464 @default.
- W3204146241 cites W2104416051 @default.
- W3204146241 cites W2110244956 @default.
- W3204146241 cites W2118390137 @default.
- W3204146241 cites W2118741003 @default.
- W3204146241 cites W2120439612 @default.
- W3204146241 cites W2131598517 @default.
- W3204146241 cites W2132790034 @default.
- W3204146241 cites W2142430376 @default.
- W3204146241 cites W2151317970 @default.
- W3204146241 cites W2155277330 @default.
- W3204146241 cites W2163776751 @default.
- W3204146241 cites W2171116985 @default.
- W3204146241 cites W2263557584 @default.
- W3204146241 cites W2287068230 @default.
- W3204146241 cites W2335930023 @default.
- W3204146241 cites W2346126921 @default.
- W3204146241 cites W2610160407 @default.
- W3204146241 cites W2738497746 @default.
- W3204146241 cites W2745816804 @default.
- W3204146241 cites W2745958356 @default.
- W3204146241 cites W2757387674 @default.
- W3204146241 cites W2757399450 @default.
- W3204146241 cites W2761461280 @default.
- W3204146241 cites W2775505403 @default.
- W3204146241 cites W2809178041 @default.
- W3204146241 cites W2809590711 @default.
- W3204146241 cites W2883065628 @default.
- W3204146241 cites W2902627262 @default.
- W3204146241 cites W2911472928 @default.
- W3204146241 cites W2913116862 @default.
- W3204146241 cites W2914173303 @default.
- W3204146241 cites W2941395492 @default.
- W3204146241 cites W2949536628 @default.
- W3204146241 cites W2951726997 @default.
- W3204146241 cites W2952984703 @default.
- W3204146241 cites W2982127583 @default.
- W3204146241 cites W2991248607 @default.
- W3204146241 cites W3000377151 @default.
- W3204146241 cites W3004890215 @default.
- W3204146241 cites W3007279945 @default.
- W3204146241 cites W3010703628 @default.
- W3204146241 cites W3022807137 @default.
- W3204146241 cites W3099165428 @default.
- W3204146241 cites W3136389052 @default.
- W3204146241 cites W3152532845 @default.
- W3204146241 doi "https://doi.org/10.1101/2021.09.24.461725" @default.
- W3204146241 hasPublicationYear "2021" @default.
- W3204146241 type Work @default.
- W3204146241 sameAs 3204146241 @default.
- W3204146241 citedByCount "0" @default.
- W3204146241 crossrefType "posted-content" @default.
- W3204146241 hasAuthorship W3204146241A5009871990 @default.
- W3204146241 hasAuthorship W3204146241A5011705834 @default.
- W3204146241 hasAuthorship W3204146241A5013561763 @default.
- W3204146241 hasAuthorship W3204146241A5089234415 @default.
- W3204146241 hasBestOaLocation W32041462411 @default.
- W3204146241 hasConcept C102744134 @default.
- W3204146241 hasConcept C104317684 @default.
- W3204146241 hasConcept C115821613 @default.
- W3204146241 hasConcept C136322937 @default.
- W3204146241 hasConcept C148196450 @default.
- W3204146241 hasConcept C152369539 @default.
- W3204146241 hasConcept C2778354886 @default.
- W3204146241 hasConcept C30481170 @default.
- W3204146241 hasConcept C54355233 @default.