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- W3204146765 abstract "Essential thrombocythemia (ET) is a chronic myelopoliferative neoplasm that involves primarily the megakaryocytic lineage. Thrombocytosis is a common hematologic finding and the ET lacks of specific genetic or biologic hallmark therefore the differential diagnosis includes several reactive and neoplastic megakariocytic proliferations. Similar laboratory findings (thrombocytosis not associated with leucocytosis, polycythemia nor anemia) as well as cytoand histologic characteristics (proliferation of the megakaryocytic lineage, without significant fibrosis, neutrophil granulopoiesis nor erythropoiesis) make difficult to distinct ET from the pre-polycythemic stage of polycythemia vera and the prefibrotic and early stage of primary mielofibrosis. An evaluation of the bone marrow biopsy meeting 2008 World Health Organization (WHO) diagnostic criteria for myeloproliferative neoplasms complying with distinctive megakariocyte morphology and distribution is diagnostic necessity. The differential diagnosis of ET is clinically important because of distinct treatment options, prognosis and disease progression such as myelofibrosis or transformation into acute myeloid leukemia." @default.
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- W3204146765 date "2012-01-01" @default.
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- W3204146765 title "Differential diagnosis of essential thrombocythemia" @default.
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