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- W3204149011 abstract "Abstract After admixture, recombination breaks down genomic blocks of contiguous ancestry. The breakdown of these blocks forms a new “molecular clock” that ticks at a much faster rate than the mutation clock, enabling accurate dating of admixture events in the recent past. However, existing theory on the breakdown of these blocks, or the accumulation of delineations between blocks, so‐called “junctions”, has mostly been limited to using regularly spaced markers on phased data. Here, we present an extension to the theory of junctions using the ancestral recombination graph that describes the expected number of junctions for any distribution of markers along the genome. Furthermore, we provide a new framework to infer the time since admixture using unphased data. We demonstrate both the phased and unphased methods on simulated data and show that our new extensions have improved accuracy with respect to previous methods, especially for smaller population sizes and more ancient admixture times. Lastly, we demonstrate the applicability of our method on three empirical data sets, including labcrosses of yeast ( Saccharomyces cerevisae ) and two case studies of hybridization in swordtail fish and Populus trees." @default.
- W3204149011 created "2021-10-11" @default.
- W3204149011 creator A5006508875 @default.
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- W3204149011 date "2021-10-10" @default.
- W3204149011 modified "2023-10-15" @default.
- W3204149011 title "Estimating the time since admixture from phased and unphased molecular data" @default.
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- W3204149011 doi "https://doi.org/10.1111/1755-0998.13519" @default.
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