FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204151075> ?p ?o ?g. }

• W3204151075 endingPage "691" @default.
• W3204151075 startingPage "681" @default.
• W3204151075 abstract "Incomplete partition type II (IP-II) is frequently identified in ears with SLC26A4 mutations. Cochleae with IP-II are generally observed to have 1½ turns; the basal turns are normally formed, and the apical turn is dilated or cystic. The objective of this study was to characterize the pathomorphogenesis of the IP-II cochlear anomaly in Slc26a4-null mice. Otic capsules were dissected from Slc26a4Δ/+ and Slc26a4Δ/Δ mice at 1 and 8 days of age and at 1 and 3 months of age. X-ray micro-computed tomography was used to image samples. We used a multiplanar view and three-dimensional reconstructed models to calculate the cochlear duct length, cochlear turn rotation angle, and modiolus tilt angle. The number of inner hair cells was counted, and the length of the cochlear duct was measured in a whole-mount preparation of the membranous labyrinth. X-ray micro-computed tomography mid-modiolar planar views demonstrated cystic apical turns in Slc26a4Δ/Δ mice resulting from the loss or deossification of the interscalar septum, which morphologically resembles IP-II in humans. Planes vertical to the modiolus showed a similar mean rotation angle between Slc26a4Δ/+ and Slc26a4Δ/Δ mice. In contrast, the mean cochlear duct length and mean number of inner hair cells in Slc26a4Δ/Δ mice were significantly smaller than in Slc26a4Δ/+ mice. In addition, there were significant differences in the mean tilt angle and mean width of the modiolus. Our analysis of Slc26a4-null mice suggests that IP-II in humans reflects loss or deossification of the interscalar septum but not a decreased number of cochlear turns." @default.
• W3204151075 created "2021-10-11" @default.
• W3204151075 creator A5004522034 @default.
• W3204151075 creator A5006059987 @default.
• W3204151075 creator A5040067120 @default.
• W3204151075 creator A5052386069 @default.
• W3204151075 creator A5061634903 @default.
• W3204151075 creator A5065236765 @default.
• W3204151075 creator A5072987336 @default.
• W3204151075 creator A5076588031 @default.
• W3204151075 creator A5087451654 @default.
• W3204151075 creator A5091492459 @default.
• W3204151075 date "2021-10-07" @default.
• W3204151075 modified "2023-10-15" @default.
• W3204151075 title "Cochlear Pathomorphogenesis of Incomplete Partition Type II in Slc26a4-Null Mice" @default.
• W3204151075 cites W1578864982 @default.
• W3204151075 cites W1995894734 @default.
• W3204151075 cites W1997917564 @default.
• W3204151075 cites W2000150330 @default.
• W3204151075 cites W2006657853 @default.
• W3204151075 cites W2011200132 @default.
• W3204151075 cites W2013218044 @default.
• W3204151075 cites W2021332009 @default.
• W3204151075 cites W2024385388 @default.
• W3204151075 cites W2026230551 @default.
• W3204151075 cites W2026616100 @default.
• W3204151075 cites W2028909148 @default.
• W3204151075 cites W2032184616 @default.
• W3204151075 cites W2036061346 @default.
• W3204151075 cites W2043511649 @default.
• W3204151075 cites W2046962116 @default.
• W3204151075 cites W2054493690 @default.
• W3204151075 cites W2055146777 @default.
• W3204151075 cites W2057833716 @default.
• W3204151075 cites W2058568752 @default.
• W3204151075 cites W2058902399 @default.
• W3204151075 cites W2065763851 @default.
• W3204151075 cites W2065987736 @default.
• W3204151075 cites W2072620398 @default.
• W3204151075 cites W2082476939 @default.
• W3204151075 cites W2097880791 @default.
• W3204151075 cites W2102326129 @default.
• W3204151075 cites W2128667883 @default.
• W3204151075 cites W2132725786 @default.
• W3204151075 cites W2138112096 @default.
• W3204151075 cites W2143944233 @default.
• W3204151075 cites W2326937106 @default.
• W3204151075 cites W2339572351 @default.
• W3204151075 cites W2412522730 @default.
• W3204151075 cites W2417960286 @default.
• W3204151075 cites W2560816968 @default.
• W3204151075 cites W2754132491 @default.
• W3204151075 cites W2783439098 @default.
• W3204151075 cites W2881529706 @default.
• W3204151075 cites W2909329664 @default.
• W3204151075 cites W2910314606 @default.
• W3204151075 cites W2963829046 @default.
• W3204151075 cites W2990742015 @default.
• W3204151075 doi "https://doi.org/10.1007/s10162-021-00812-4" @default.
• W3204151075 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8599553" @default.
• W3204151075 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34622375" @default.
• W3204151075 hasPublicationYear "2021" @default.
• W3204151075 type Work @default.
• W3204151075 sameAs 3204151075 @default.
• W3204151075 citedByCount "3" @default.
• W3204151075 countsByYear W32041510752023 @default.
• W3204151075 crossrefType "journal-article" @default.
• W3204151075 hasAuthorship W3204151075A5004522034 @default.
• W3204151075 hasAuthorship W3204151075A5006059987 @default.
• W3204151075 hasAuthorship W3204151075A5040067120 @default.
• W3204151075 hasAuthorship W3204151075A5052386069 @default.
• W3204151075 hasAuthorship W3204151075A5061634903 @default.
• W3204151075 hasAuthorship W3204151075A5065236765 @default.
• W3204151075 hasAuthorship W3204151075A5072987336 @default.
• W3204151075 hasAuthorship W3204151075A5076588031 @default.
• W3204151075 hasAuthorship W3204151075A5087451654 @default.
• W3204151075 hasAuthorship W3204151075A5091492459 @default.
• W3204151075 hasBestOaLocation W32041510752 @default.
• W3204151075 hasConcept C105702510 @default.
• W3204151075 hasConcept C134018914 @default.
• W3204151075 hasConcept C2778024521 @default.
• W3204151075 hasConcept C2778500370 @default.
• W3204151075 hasConcept C2779306644 @default.
• W3204151075 hasConcept C2780130748 @default.
• W3204151075 hasConcept C2781094566 @default.
• W3204151075 hasConcept C2781413191 @default.
• W3204151075 hasConcept C86803240 @default.
• W3204151075 hasConceptScore W3204151075C105702510 @default.
• W3204151075 hasConceptScore W3204151075C134018914 @default.
• W3204151075 hasConceptScore W3204151075C2778024521 @default.
• W3204151075 hasConceptScore W3204151075C2778500370 @default.
• W3204151075 hasConceptScore W3204151075C2779306644 @default.
• W3204151075 hasConceptScore W3204151075C2780130748 @default.
• W3204151075 hasConceptScore W3204151075C2781094566 @default.
• W3204151075 hasConceptScore W3204151075C2781413191 @default.
• W3204151075 hasConceptScore W3204151075C86803240 @default.
• W3204151075 hasIssue "6" @default.
• W3204151075 hasLocation W32041510751 @default.

• next