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• W3204158406 abstract "Abstract Background In the cerebellar cortex, Purkinje cells are the only output neurons and exhibit two types of discharge. Most Purkinje cell discharges are simple spikes, which are commonly appearing action potentials exhibiting a rich variety of firing patterns with a rate of up to 400 Hz. More infrequent discharges are complex spikes, which consist of a short burst of impulses accompanied by a massive increase in dendritic Ca 2+ with a firing rate of around 1 Hz. The discrimination of these spikes in extracellular single-unit recordings is not always straightforward, as their waveforms vary depending on recording conditions and intrinsic fluctuations. New Method To discriminate complex spikes from simple spikes in the extracellular single-unit data, we developed a semiautomatic spike-sorting method based on divisive hierarchical clustering. Results Quantitative evaluation using parallel in vivo two-photon Ca 2+ imaging of Purkinje cell dendrites indicated that 96.6% of the complex spikes were detected using our spike-sorting method from extracellular single-unit recordings obtained from anesthetized mice. Comparison with Existing Method(s) No reports have conducted a quantitative evaluation of spike-sorting algorithms used for the classification of extracellular spikes recorded from cerebellar Purkinje cells. Conclusions Our method could be expected to contribute to research in information processing in the cerebellar cortex and the development of a fully automatic spike-sorting algorithm by providing ground-truth data useful for deep learning. Highlights A spike-sorting algorithm on hierarchical clustering was developed. It was applied to extracellular recordings from cerebellar Purkinje cells. Complex and simple spikes were discriminated based on their waveforms. Spike-sorting performance was quantified using in vivo Ca 2+ imaging data. The algorithm isolated over 96.6% of complex spikes." @default.
• W3204158406 created "2021-10-11" @default.
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• W3204158406 date "2021-10-01" @default.
• W3204158406 modified "2023-09-27" @default.
• W3204158406 title "A spike-sorting method based on hierarchical clustering to discriminate extracellularly recorded simple spikes and complex spikes from cerebellar Purkinje cells" @default.
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• W3204158406 doi "https://doi.org/10.1101/2021.09.30.462526" @default.
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