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- W3204162334 startingPage "3356" @default.
- W3204162334 abstract "Lactoferrin (LF) was used at first as a vehicle to deliver non-soluble active compounds to the body, including the central nervous system (CNS). Nonetheless, it soon became evident that, apart from acting as a vehicle, LF itself owns active effects in the CNS. In the present study, the effects of LF are assessed both in baseline conditions, as well as to counteract methamphetamine (METH)-induced neurodegeneration by assessing cell viability, cell phenotype, mitochondrial status, and specific autophagy steps. In detail, cell integrity in baseline conditions and following METH administration was carried out by using H&E staining, Trypan blue, Fluoro Jade B, and WST-1. Western blot and immuno-fluorescence were used to assess the expression of the neurofilament marker βIII-tubulin. Mitochondria were stained using Mito Tracker Red and Green and were further detailed and quantified by using transmission electron microscopy. Autophagy markers were analyzed through immuno-fluorescence and electron microscopy. LF counteracts METH-induced degeneration. In detail, LF significantly attenuates the amount of cell loss and mitochondrial alterations produced by METH; and mitigates the dissipation of autophagy-related proteins from the autophagy compartment, which is massively induced by METH. These findings indicate a protective role of LF in the molecular mechanisms of neurodegeneration." @default.
- W3204162334 created "2021-10-11" @default.
- W3204162334 creator A5002108536 @default.
- W3204162334 creator A5009372916 @default.
- W3204162334 creator A5017946424 @default.
- W3204162334 creator A5032981915 @default.
- W3204162334 creator A5045284704 @default.
- W3204162334 creator A5049503029 @default.
- W3204162334 creator A5067262146 @default.
- W3204162334 creator A5068984003 @default.
- W3204162334 date "2021-09-25" @default.
- W3204162334 modified "2023-10-03" @default.
- W3204162334 title "Lactoferrin Protects against Methamphetamine Toxicity by Modulating Autophagy and Mitochondrial Status" @default.
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