FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204162855> ?p ?o ?g. }

• W3204162855 endingPage "1994" @default.
• W3204162855 startingPage "1994" @default.
• W3204162855 abstract "African swine fever virus (ASFV) is the etiological agent of the devastating disease African swine fever (ASF), for which there is currently no licensed vaccine or treatment available. ASF is defined as one of the most serious animal diseases identified to date, due to its global spread in regions of Africa, Europe and Asia, causing massive economic losses. On the Italian island of Sardinia, the disease has been endemic since 1978, although the last control measures put in place achieved a significant reduction in ASF, and the virus has been absent from circulation since April 2019. Like many large DNA viruses, ASFV mutates at a relatively slow rate. However, the limited availability of whole-genome sequences from spatial-localized outbreaks makes it difficult to explore the small-scale genetic structure of these ASFV outbreaks. It is also unclear if the genetic variability within outbreaks can be captured in a handful of sequences, or if larger sequencing efforts can improve phylogenetic reconstruction and evolutionary or epidemiological inference. The aim of this study was to investigate the phylogenetic patterns of ASFV outbreaks between 1978 and 2018 in Sardinia, in order to characterize the epidemiological dynamics of the viral strains circulating in this Mediterranean island. To reach this goal, 58 new whole genomes of ASFV isolates were obtained, which represents the largest ASFV whole-genome sequencing effort to date. We provided a complete description of the genomic diversity of ASFV in terms of nucleotide mutations and small and large indels among the isolates collected during the outbreaks. The new sequences capture more than twice the genomic and phylogenetic diversity of all the previously published Sardinian sequences. The extra genomic diversity increases the resolution of the phylogenetic reconstruction, enabling us to dissect, for the first time, the genetic substructure of the outbreak. We found multiple ASFV subclusters within the phylogeny of the Sardinian epidemic, some of which coexisted in space and time." @default.
• W3204162855 created "2021-10-11" @default.
• W3204162855 creator A5012559765 @default.
• W3204162855 creator A5012685111 @default.
• W3204162855 creator A5015646385 @default.
• W3204162855 creator A5022211262 @default.
• W3204162855 creator A5027275112 @default.
• W3204162855 creator A5040431199 @default.
• W3204162855 creator A5045457353 @default.
• W3204162855 creator A5054667383 @default.
• W3204162855 creator A5059346220 @default.
• W3204162855 creator A5061291187 @default.
• W3204162855 creator A5063662467 @default.
• W3204162855 creator A5064740851 @default.
• W3204162855 creator A5072082339 @default.
• W3204162855 creator A5074992470 @default.
• W3204162855 creator A5075410415 @default.
• W3204162855 creator A5083157369 @default.
• W3204162855 creator A5090641847 @default.
• W3204162855 date "2021-10-04" @default.
• W3204162855 modified "2023-10-14" @default.
• W3204162855 title "A Deeper Insight into Evolutionary Patterns and Phylogenetic History of ASFV Epidemics in Sardinia (Italy) through Extensive Genomic Sequencing" @default.
• W3204162855 cites W1505285086 @default.
• W3204162855 cites W1529731847 @default.
• W3204162855 cites W1928220195 @default.
• W3204162855 cites W1969042907 @default.
• W3204162855 cites W1970424608 @default.
• W3204162855 cites W1970558084 @default.
• W3204162855 cites W2009894079 @default.
• W3204162855 cites W2021341670 @default.
• W3204162855 cites W2025648894 @default.
• W3204162855 cites W2035394605 @default.
• W3204162855 cites W2060614612 @default.
• W3204162855 cites W2071551214 @default.
• W3204162855 cites W2088267428 @default.
• W3204162855 cites W2094206246 @default.
• W3204162855 cites W2098466396 @default.
• W3204162855 cites W2099400747 @default.
• W3204162855 cites W2103441770 @default.
• W3204162855 cites W2110835349 @default.
• W3204162855 cites W2115809399 @default.
• W3204162855 cites W2120772351 @default.
• W3204162855 cites W2125275725 @default.
• W3204162855 cites W2127396309 @default.
• W3204162855 cites W2127755041 @default.
• W3204162855 cites W2140644293 @default.
• W3204162855 cites W2146773981 @default.
• W3204162855 cites W2148534890 @default.
• W3204162855 cites W2148698435 @default.
• W3204162855 cites W2149843737 @default.
• W3204162855 cites W2150131459 @default.
• W3204162855 cites W2160378127 @default.
• W3204162855 cites W2163409779 @default.
• W3204162855 cites W2166655850 @default.
• W3204162855 cites W2170996473 @default.
• W3204162855 cites W2183655260 @default.
• W3204162855 cites W2369255521 @default.
• W3204162855 cites W2408278917 @default.
• W3204162855 cites W2477283948 @default.
• W3204162855 cites W2528710016 @default.
• W3204162855 cites W2549819640 @default.
• W3204162855 cites W2598295939 @default.
• W3204162855 cites W2613902351 @default.
• W3204162855 cites W2741335722 @default.
• W3204162855 cites W2755970137 @default.
• W3204162855 cites W2764147189 @default.
• W3204162855 cites W2789467228 @default.
• W3204162855 cites W2792950703 @default.
• W3204162855 cites W2801159594 @default.
• W3204162855 cites W2808545927 @default.
• W3204162855 cites W2883251903 @default.
• W3204162855 cites W2887875179 @default.
• W3204162855 cites W2896124400 @default.
• W3204162855 cites W2909078909 @default.
• W3204162855 cites W2911347096 @default.
• W3204162855 cites W2918407118 @default.
• W3204162855 cites W2949793465 @default.
• W3204162855 cites W2967564026 @default.
• W3204162855 cites W2969359921 @default.
• W3204162855 cites W2998391065 @default.
• W3204162855 cites W3011991772 @default.
• W3204162855 cites W3081464932 @default.
• W3204162855 cites W3086500137 @default.
• W3204162855 cites W3087307066 @default.
• W3204162855 cites W3097432845 @default.
• W3204162855 cites W3133726518 @default.
• W3204162855 cites W3134415684 @default.
• W3204162855 cites W3157176690 @default.
• W3204162855 cites W3187962553 @default.
• W3204162855 cites W3192633879 @default.
• W3204162855 cites W3210260466 @default.
• W3204162855 cites W4211177544 @default.
• W3204162855 doi "https://doi.org/10.3390/v13101994" @default.
• W3204162855 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8539718" @default.
• W3204162855 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34696424" @default.
• W3204162855 hasPublicationYear "2021" @default.
• W3204162855 type Work @default.
• W3204162855 sameAs 3204162855 @default.

• next