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• W3204162893 abstract "Abnormal activation of fibroblasts plays a crucial role in keloid development. However, the mechanism of fibroblast activation remains to be determined. YAP/TAZ are key molecules in the Hippo signalling pathway that promote cell proliferation and inhibit apoptosis. Here, we show that keloid fibroblasts have higher levels of YAP/TAZ mRNA and proteins on primary culture. Targeted knockdown of endogenous YAP or TAZ significantly inhibited cell proliferation, reduced cell migration, induced cell apoptosis and down-regulated collagen1a1 production by keloid fibroblasts. Moreover, we demonstrate that verteporfin, an inhibitor of YAP/TAZ, has similar but stronger inhibitory effects on fibroblasts compared to YAP/TAZ knockdown. Our study provides evidence that YAP/TAZ may be involved in the pathogenesis of keloids. Targeted inhibition of YAP/TAZ could change the biological behaviours of fibroblasts and can potentially be used as therapy for keloids." @default.
• W3204162893 created "2021-10-11" @default.
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• W3204162893 date "2021-10-19" @default.
• W3204162893 modified "2023-10-14" @default.
• W3204162893 title "Targeted inhibition of YAP/TAZ alters the biological behaviours of keloid fibroblasts" @default.
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• W3204162893 doi "https://doi.org/10.1111/exd.14466" @default.
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