Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204163236> ?p ?o ?g. }
- W3204163236 endingPage "e296" @default.
- W3204163236 startingPage "e296" @default.
- W3204163236 abstract "The novel severe acute respiratory syndrome coronavirus 2 pandemic continues to spread globally without an effective treatment. In search of the cure, convalescent plasma (CP) containing protective antibodies from survivors of coronavirus disease 2019 (COVID-19) infection has shown potential benefit in a non-intensive care unit setting. We sought to evaluate the effectiveness of CP therapy for patients with COVID-19 on mechanical ventilation (MV) and/or acute respiratory distress syndrome (ARDS).We conducted an open-label trial in a single center, Royal Hospital, in Oman. The study was conducted from 17 April to 20 June 2020. The trial included 94 participants with laboratory-confirmed COVID-19. The primary outcomes included extubation rates, discharges from the hospital and overall mortality, while secondary outcomes were the length of stay and improvement in respiratory and laboratory parameters. Analyses were performed using univariate statistics.The overall mean age of the cohort was 50.0±15.0 years, and 90.4% (n = 85) were males. A total of 77.7% (n = 73) of patients received CP. Those on CP were associated with a higher extubation rate (35.6% vs. 76.2%; p < 0.001), higher extubation/home discharges rate (64.4% vs. 23.8%; p =0.001), and tendency towards lower overall mortality (19.2% vs. 28.6%; p =0.354; study power = 11.0%) when compared to COVID-19 patients that did not receive CP.CP was associated with higher extubation/home discharges and a tendency towards lower overall mortality when compared to those that did not receive CP in COVID-19 patients on MV or in those with ARDS. Further studies are warranted to corroborate our findings." @default.
- W3204163236 created "2021-10-11" @default.
- W3204163236 creator A5004748750 @default.
- W3204163236 creator A5011674708 @default.
- W3204163236 creator A5035404662 @default.
- W3204163236 creator A5040046708 @default.
- W3204163236 creator A5047427323 @default.
- W3204163236 creator A5053298688 @default.
- W3204163236 creator A5069826262 @default.
- W3204163236 creator A5083264944 @default.
- W3204163236 creator A5087537812 @default.
- W3204163236 creator A5090232908 @default.
- W3204163236 date "2021-09-15" @default.
- W3204163236 modified "2023-10-18" @default.
- W3204163236 title "Convalescent Plasma Therapy in Critically Ill COVID-19 Patients: An Open Label Trial" @default.
- W3204163236 cites W1803784511 @default.
- W3204163236 cites W2060723289 @default.
- W3204163236 cites W2096238447 @default.
- W3204163236 cites W2133701960 @default.
- W3204163236 cites W2280404143 @default.
- W3204163236 cites W2610356532 @default.
- W3204163236 cites W2620241325 @default.
- W3204163236 cites W2791163322 @default.
- W3204163236 cites W3008954191 @default.
- W3204163236 cites W3011379523 @default.
- W3204163236 cites W3013525829 @default.
- W3204163236 cites W3013742505 @default.
- W3204163236 cites W3014168462 @default.
- W3204163236 cites W3014185271 @default.
- W3204163236 cites W3014735311 @default.
- W3204163236 cites W3014853902 @default.
- W3204163236 cites W3015662129 @default.
- W3204163236 cites W3016489853 @default.
- W3204163236 cites W3016779347 @default.
- W3204163236 cites W3018000548 @default.
- W3204163236 cites W3019282223 @default.
- W3204163236 cites W3019834697 @default.
- W3204163236 cites W3021816206 @default.
- W3204163236 cites W3023650684 @default.
- W3204163236 cites W3023698370 @default.
- W3204163236 cites W3024465342 @default.
- W3204163236 cites W3026440279 @default.
- W3204163236 cites W3031672949 @default.
- W3204163236 cites W3032003277 @default.
- W3204163236 cites W3033732083 @default.
- W3204163236 cites W3034286795 @default.
- W3204163236 cites W3035163373 @default.
- W3204163236 cites W3035614443 @default.
- W3204163236 cites W3037832934 @default.
- W3204163236 cites W3040431017 @default.
- W3204163236 cites W3040580036 @default.
- W3204163236 cites W3042487110 @default.
- W3204163236 cites W3042890801 @default.
- W3204163236 cites W3043433431 @default.
- W3204163236 cites W3105818049 @default.
- W3204163236 doi "https://doi.org/10.5001/omj.2021.105" @default.
- W3204163236 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8491110" @default.
- W3204163236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34631155" @default.
- W3204163236 hasPublicationYear "2021" @default.
- W3204163236 type Work @default.
- W3204163236 sameAs 3204163236 @default.
- W3204163236 citedByCount "3" @default.
- W3204163236 countsByYear W32041632362022 @default.
- W3204163236 countsByYear W32041632362023 @default.
- W3204163236 crossrefType "journal-article" @default.
- W3204163236 hasAuthorship W3204163236A5004748750 @default.
- W3204163236 hasAuthorship W3204163236A5011674708 @default.
- W3204163236 hasAuthorship W3204163236A5035404662 @default.
- W3204163236 hasAuthorship W3204163236A5040046708 @default.
- W3204163236 hasAuthorship W3204163236A5047427323 @default.
- W3204163236 hasAuthorship W3204163236A5053298688 @default.
- W3204163236 hasAuthorship W3204163236A5069826262 @default.
- W3204163236 hasAuthorship W3204163236A5083264944 @default.
- W3204163236 hasAuthorship W3204163236A5087537812 @default.
- W3204163236 hasAuthorship W3204163236A5090232908 @default.
- W3204163236 hasBestOaLocation W32041632361 @default.
- W3204163236 hasConcept C126322002 @default.
- W3204163236 hasConcept C144301174 @default.
- W3204163236 hasConcept C168563851 @default.
- W3204163236 hasConcept C179755657 @default.
- W3204163236 hasConcept C194828623 @default.
- W3204163236 hasConcept C2776348555 @default.
- W3204163236 hasConcept C2776376669 @default.
- W3204163236 hasConcept C2777080012 @default.
- W3204163236 hasConcept C2777714996 @default.
- W3204163236 hasConcept C2779134260 @default.
- W3204163236 hasConcept C3008058167 @default.
- W3204163236 hasConcept C38180746 @default.
- W3204163236 hasConcept C524204448 @default.
- W3204163236 hasConcept C71924100 @default.
- W3204163236 hasConcept C89623803 @default.
- W3204163236 hasConceptScore W3204163236C126322002 @default.
- W3204163236 hasConceptScore W3204163236C144301174 @default.
- W3204163236 hasConceptScore W3204163236C168563851 @default.
- W3204163236 hasConceptScore W3204163236C179755657 @default.
- W3204163236 hasConceptScore W3204163236C194828623 @default.
- W3204163236 hasConceptScore W3204163236C2776348555 @default.
- W3204163236 hasConceptScore W3204163236C2776376669 @default.