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- W3204165356 abstract "Fetal growth restriction (FGR) is common, affecting around 10% of all pregnancies. Growth restricted fetuses fail to achieve their genetically predetermined size and often weigh <10th centile for gestation. However, even appropriately grown fetuses can be affected, with the diagnosis of FGR missed before birth. Babies with FGR have a higher rate of stillbirth, neonatal morbidity such as breathing problems, and neurodevelopmental delay. FGR is usually due to placental insufficiency leading to poor placental perfusion and fetal hypoxia. MRI is increasingly used to image the fetus and placenta. Here we explore the use of novel multi-compartment Intravoxel Incoherent Motion Model (IVIM)-based models for MRI fetal and placental analysis, to improve understanding of FGR and quantify abnormalities and biomarkers in fetal organs. In 12 normally grown and 12 FGR gestational-age matched pregnancies (Median 28(^{+4})wks±3(^{+3})wks) we acquired T(_{2}) relaxometry and diffusion MRI datasets. Decreased perfusion, pseudo-diffusion coefficient, and fetal blood T(_{2}) values in the placenta and fetal liver were significant features distinguishing between FGR and normal controls (p-value <0.05). This may be related to the preferential shunting of fetal blood away from the fetal liver to the fetal brain that occurs in placental insufficiency. These features were used to predict FGR diagnosis and gestational age at delivery using simple machine learning models. Texture analysis was explored to compare Haralick features between control and FGR fetuses, with the placenta and liver yielding the most significant differences between the groups. This project provides insights into the effect of FGR on fetal organs emphasizing the significant impact on the fetal liver and placenta, and the potential of an automated approach to diagnosis by leveraging simple machine learning models." @default.
- W3204165356 created "2021-10-11" @default.
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- W3204165356 date "2021-01-01" @default.
- W3204165356 modified "2023-09-23" @default.
- W3204165356 title "Texture-Based Analysis of Fetal Organs in Fetal Growth Restriction" @default.
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- W3204165356 doi "https://doi.org/10.1007/978-3-030-87735-4_24" @default.
- W3204165356 hasPublicationYear "2021" @default.
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