Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204168401> ?p ?o ?g. }
- W3204168401 endingPage "108822" @default.
- W3204168401 startingPage "108822" @default.
- W3204168401 abstract "Parkinson's disease (PD) is defined as a complex disorder with multifactorial pathogenesis, yet a more accurate definition could be that PD is not a single entity, but rather a mixture of different diseases with similar phenotypes. Attempts to classify subtypes of PD have been made based on clinical phenotypes or biomarkers. However, the most practical approach, at least for a portion of the patients, could be to classify patients based on genes involved in PD. GBA and LRRK2 mutations are the most common genetic causes or risk factors of PD, and PRKN is the most common cause of autosomal recessive form of PD. Patients carrying variants in GBA, LRRK2 or PRKN differ in some of their clinical characteristics, pathology and biochemical parameters. Thus, these three PD-associated genes are of special interest for drug development. Existing therapeutic approaches in PD are strictly symptomatic, as numerous clinical trials aimed at modifying PD progression or providing neuroprotection have failed over the last few decades. The lack of precision medicine approach in most of these trials could be one of the reasons why they were not successful. In the current review we discuss novel therapeutic approaches targeting GBA, LRRK2 and PRKN and discuss different aspects related to these genes and clinical trials." @default.
- W3204168401 created "2021-10-11" @default.
- W3204168401 creator A5002529713 @default.
- W3204168401 creator A5003000740 @default.
- W3204168401 creator A5089452258 @default.
- W3204168401 date "2022-01-01" @default.
- W3204168401 modified "2023-10-15" @default.
- W3204168401 title "New therapeutic approaches to Parkinson's disease targeting GBA, LRRK2 and Parkin" @default.
- W3204168401 cites W1256777839 @default.
- W3204168401 cites W1501190799 @default.
- W3204168401 cites W1533651529 @default.
- W3204168401 cites W1544068927 @default.
- W3204168401 cites W1558432922 @default.
- W3204168401 cites W1654896864 @default.
- W3204168401 cites W1758125525 @default.
- W3204168401 cites W1877873625 @default.
- W3204168401 cites W1879602048 @default.
- W3204168401 cites W1935921385 @default.
- W3204168401 cites W1960643454 @default.
- W3204168401 cites W1967472687 @default.
- W3204168401 cites W1974081722 @default.
- W3204168401 cites W1975932268 @default.
- W3204168401 cites W1976082900 @default.
- W3204168401 cites W1979395048 @default.
- W3204168401 cites W1985667263 @default.
- W3204168401 cites W1989089334 @default.
- W3204168401 cites W1992253341 @default.
- W3204168401 cites W1992632425 @default.
- W3204168401 cites W1996637092 @default.
- W3204168401 cites W1997536147 @default.
- W3204168401 cites W2002577886 @default.
- W3204168401 cites W2004865303 @default.
- W3204168401 cites W2006578754 @default.
- W3204168401 cites W2011977459 @default.
- W3204168401 cites W2022921936 @default.
- W3204168401 cites W2023250031 @default.
- W3204168401 cites W2026548628 @default.
- W3204168401 cites W2027459860 @default.
- W3204168401 cites W2028245787 @default.
- W3204168401 cites W2031365272 @default.
- W3204168401 cites W2039304191 @default.
- W3204168401 cites W2041290559 @default.
- W3204168401 cites W2043492026 @default.
- W3204168401 cites W2046060766 @default.
- W3204168401 cites W2052928832 @default.
- W3204168401 cites W2055487675 @default.
- W3204168401 cites W2059721073 @default.
- W3204168401 cites W2063127941 @default.
- W3204168401 cites W2072066672 @default.
- W3204168401 cites W2072241333 @default.
- W3204168401 cites W2077152033 @default.
- W3204168401 cites W2078411668 @default.
- W3204168401 cites W2079133058 @default.
- W3204168401 cites W2079985938 @default.
- W3204168401 cites W2080221684 @default.
- W3204168401 cites W2081455544 @default.
- W3204168401 cites W2082577333 @default.
- W3204168401 cites W2096916909 @default.
- W3204168401 cites W2099131241 @default.
- W3204168401 cites W2099739812 @default.
- W3204168401 cites W2100300726 @default.
- W3204168401 cites W2103454698 @default.
- W3204168401 cites W2116709932 @default.
- W3204168401 cites W2117227053 @default.
- W3204168401 cites W2118225942 @default.
- W3204168401 cites W2118598201 @default.
- W3204168401 cites W2122641909 @default.
- W3204168401 cites W2124999533 @default.
- W3204168401 cites W2131251654 @default.
- W3204168401 cites W2131476886 @default.
- W3204168401 cites W2134829539 @default.
- W3204168401 cites W2136230100 @default.
- W3204168401 cites W2137300912 @default.
- W3204168401 cites W2145147096 @default.
- W3204168401 cites W2145515423 @default.
- W3204168401 cites W2150098266 @default.
- W3204168401 cites W2154155955 @default.
- W3204168401 cites W2157765536 @default.
- W3204168401 cites W2163130181 @default.
- W3204168401 cites W2164649819 @default.
- W3204168401 cites W2167552109 @default.
- W3204168401 cites W2170281382 @default.
- W3204168401 cites W2173737475 @default.
- W3204168401 cites W2277130721 @default.
- W3204168401 cites W2297229933 @default.
- W3204168401 cites W2340165674 @default.
- W3204168401 cites W2464353788 @default.
- W3204168401 cites W2479157102 @default.
- W3204168401 cites W2509904505 @default.
- W3204168401 cites W2516366589 @default.
- W3204168401 cites W2523238466 @default.
- W3204168401 cites W2525713139 @default.
- W3204168401 cites W2537718153 @default.
- W3204168401 cites W2539378148 @default.
- W3204168401 cites W2559604477 @default.
- W3204168401 cites W2563187951 @default.
- W3204168401 cites W2586458775 @default.
- W3204168401 cites W2588291989 @default.