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• W3204168476 abstract "Small cell lung cancer (SCLC) displays high genomic instability. Therefore, targeting key proteins involved in maintaining genomic stability, such as ataxia telangiectasia and Rad3-related (ATR) protein kinase and topoisomerase I (TOP1), is a rational treatment strategy for SCLC. Berzosertib (M6620), an intravenous, highly potent and selective, first-in-class ATR inhibitor, is well tolerated and synergizes with topotecan (TOP1 inhibitor) in patients with advanced solid tumors, particularly those with platinum (plt)-resistant SCLC." @default.
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• W3204168476 date "2021-09-01" @default.
• W3204168476 modified "2023-10-18" @default.
• W3204168476 title "1666TiP Phase II study of berzosertib (M6620) + topotecan in patients with relapsed platinum-resistant SCLC: DDRiver SCLC 250" @default.
• W3204168476 doi "https://doi.org/10.1016/j.annonc.2021.08.250" @default.
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