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- W3204172418 endingPage "1089" @default.
- W3204172418 startingPage "1061" @default.
- W3204172418 abstract "Neuroendocrine neoplasms (NENs) represent a rare and heterogeneous group of malignancies which can develop in many different sites of our body. They originate from the cells of the diffuse neuroendocrine system. Gastroenteropancreatic NENs were classified in four categories, including NETs G1 (WD with <3% Ki-67), NETs G2 (WD with 3–20% Ki-67), NETs G3 (WD with >20% Ki-67), and NECs (PD with >20% Ki-67) in accordance with the 2019 WHO classification (IARC WHO Classification of the digestive system tumors, on 11th July 2019). Lung NENs, in accordance with the latest WHO classification, 2015 edition, are distinguished in small cell lung cancer (SCLC), large cell neuroendocrine carcinoma (LCNEC), atypical carcinoid (AC), and typical carcinoid (TC).From a clinical perspective, it is critical to distinguish GEP NENs in functioning and nonfunctioning. The former regards the presence of a clinical syndrome related to the production of one or more substances or hormones by the tumor, whereas the latter indicates the absence of a clinical syndrome related to the tumor although the patient can be symptomatic due to mass-effect symptoms related to the tumor and/or the tumor can secrete some substances without any clinical implication." @default.
- W3204172418 created "2021-10-11" @default.
- W3204172418 creator A5000995161 @default.
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- W3204172418 creator A5078823780 @default.
- W3204172418 date "2021-01-01" @default.
- W3204172418 modified "2023-09-26" @default.
- W3204172418 title "Neuroendocrine Neoplasms (NENs)" @default.
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