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• W3204178270 endingPage "154891" @default.
• W3204178270 startingPage "154891" @default.
• W3204178270 abstract "Insulin affects the vascular tone through multiple and complex mechanisms involving both vasodilator and vasoconstrictor pathways (Fig. 1) that are further regulated by specific physiologic and pathologic conditions, including insulin resistance. Insulin receptors are present on both endothelial and smooth muscle cells. In the former, binding to the receptor leads to the activation of nitric oxide (NO) synthase and the release of prostaglandin I2 (PgI2) through the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling, while through the RAF/mitogen activated protein kinase (MAPK) signaling cascade the synthesis of Endothelin-1 is enhanced." @default.
• W3204178270 created "2021-10-11" @default.
• W3204178270 creator A5005504738 @default.
• W3204178270 creator A5055458112 @default.
• W3204178270 date "2021-11-01" @default.
• W3204178270 modified "2023-09-30" @default.
• W3204178270 title "Vascular effects of insulin" @default.
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• W3204178270 doi "https://doi.org/10.1016/j.metabol.2021.154891" @default.
• W3204178270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34563557" @default.

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