FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204182670> ?p ?o ?g. }

• W3204182670 abstract "Introduction High-dose chemotherapy followed by autologous hematopoietic stem cell transplantation (auto-HSCT) represents a standard treatment regime for multiple myeloma (MM) patients. Common and potentially fatal side effects after auto-HSCT are infections due to a severely compromised immune system with hampered humoral and cellular immunity. This study delineates in depth the quantitative and functional B cell defects and investigates underlying extrinsic or intrinsic drivers. Methods Peripheral blood of MM patients undergoing high-dose chemotherapy and auto-HSCT (before high-dose chemotherapy and in early reconstitution after HSCT) was studied. Absolute numbers and distribution of B cell subsets were analyzed ex vivo using flow cytometry. Additionally, B cell function was assessed with T cell dependent (TD) and T cell independent (TI) stimulation assays, analyzing proliferation and differentiation of B cells by flow cytometry and numbers of immunoglobulin secreting cells in ELISpots. Results Quantitative B cell defects including a shift in the B cell subset distribution occurred after auto-HSCT. Functionally, these patients showed an impaired TD as well as TI B cell immune response. Individual functional responses correlated with quantitative alterations of CD19+, CD4+, memory B cells and marginal zone-like B cells. The TD B cell function could be partially restored upon stimulation with CD40L/IL-21, successfully inducing B cell proliferation and differentiation into plasmablasts and immunoglobulin secreting cells. Conclusion Quantitative and functional B cell defects contribute to the compromised immune defense in MM patients undergoing auto-HSCT. Functional recovery upon TD stimulation and correlation with CD4+ T cell numbers, indicate these as extrinsic drivers of the functional B cell defect. Observed correlations of CD4+, CD19+, memory B and MZ-like B cell numbers with the B cell function suggest that these markers should be tested as potential biomarkers in prospective studies." @default.
• W3204182670 created "2021-10-11" @default.
• W3204182670 creator A5009133499 @default.
• W3204182670 creator A5022496168 @default.
• W3204182670 creator A5030521330 @default.
• W3204182670 creator A5036541933 @default.
• W3204182670 creator A5038582279 @default.
• W3204182670 creator A5040956966 @default.
• W3204182670 creator A5065928653 @default.
• W3204182670 creator A5067544558 @default.
• W3204182670 creator A5068697219 @default.
• W3204182670 creator A5075131981 @default.
• W3204182670 creator A5088299161 @default.
• W3204182670 creator A5089758540 @default.
• W3204182670 date "2021-09-29" @default.
• W3204182670 modified "2023-10-02" @default.
• W3204182670 title "CD4+ T Cell Dependent B Cell Recovery and Function After Autologous Hematopoietic Stem Cell Transplantation" @default.
• W3204182670 cites W1503765073 @default.
• W3204182670 cites W1504970236 @default.
• W3204182670 cites W1538324437 @default.
• W3204182670 cites W1631679200 @default.
• W3204182670 cites W1781325596 @default.
• W3204182670 cites W1882673640 @default.
• W3204182670 cites W1929236283 @default.
• W3204182670 cites W1976954882 @default.
• W3204182670 cites W1978643311 @default.
• W3204182670 cites W1982235189 @default.
• W3204182670 cites W1989238658 @default.
• W3204182670 cites W1991928493 @default.
• W3204182670 cites W2016055200 @default.
• W3204182670 cites W2016579648 @default.
• W3204182670 cites W2016857765 @default.
• W3204182670 cites W2017390384 @default.
• W3204182670 cites W2019454556 @default.
• W3204182670 cites W2019622169 @default.
• W3204182670 cites W2026368156 @default.
• W3204182670 cites W2031026925 @default.
• W3204182670 cites W2039787192 @default.
• W3204182670 cites W2045667534 @default.
• W3204182670 cites W2048669475 @default.
• W3204182670 cites W2065293336 @default.
• W3204182670 cites W2071380288 @default.
• W3204182670 cites W2086149900 @default.
• W3204182670 cites W2087900405 @default.
• W3204182670 cites W2099739487 @default.
• W3204182670 cites W2105353686 @default.
• W3204182670 cites W2110289042 @default.
• W3204182670 cites W2129509656 @default.
• W3204182670 cites W2132968076 @default.
• W3204182670 cites W2139237097 @default.
• W3204182670 cites W2143425592 @default.
• W3204182670 cites W2161132784 @default.
• W3204182670 cites W2163206714 @default.
• W3204182670 cites W2165197737 @default.
• W3204182670 cites W2166103269 @default.
• W3204182670 cites W2166559731 @default.
• W3204182670 cites W2168379509 @default.
• W3204182670 cites W2170571745 @default.
• W3204182670 cites W2290604176 @default.
• W3204182670 cites W2326590785 @default.
• W3204182670 cites W2388836266 @default.
• W3204182670 cites W2407197669 @default.
• W3204182670 cites W2486629951 @default.
• W3204182670 cites W2779323230 @default.
• W3204182670 cites W2913828721 @default.
• W3204182670 cites W2947136121 @default.
• W3204182670 cites W2970617452 @default.
• W3204182670 cites W3092434879 @default.
• W3204182670 cites W311038564 @default.
• W3204182670 cites W322788144 @default.
• W3204182670 cites W4254436884 @default.
• W3204182670 doi "https://doi.org/10.3389/fimmu.2021.736137" @default.
• W3204182670 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8519398" @default.
• W3204182670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34659226" @default.
• W3204182670 hasPublicationYear "2021" @default.
• W3204182670 type Work @default.
• W3204182670 sameAs 3204182670 @default.
• W3204182670 citedByCount "1" @default.
• W3204182670 countsByYear W32041826702023 @default.
• W3204182670 crossrefType "journal-article" @default.
• W3204182670 hasAuthorship W3204182670A5009133499 @default.
• W3204182670 hasAuthorship W3204182670A5022496168 @default.
• W3204182670 hasAuthorship W3204182670A5030521330 @default.
• W3204182670 hasAuthorship W3204182670A5036541933 @default.
• W3204182670 hasAuthorship W3204182670A5038582279 @default.
• W3204182670 hasAuthorship W3204182670A5040956966 @default.
• W3204182670 hasAuthorship W3204182670A5065928653 @default.
• W3204182670 hasAuthorship W3204182670A5067544558 @default.
• W3204182670 hasAuthorship W3204182670A5068697219 @default.
• W3204182670 hasAuthorship W3204182670A5075131981 @default.
• W3204182670 hasAuthorship W3204182670A5088299161 @default.
• W3204182670 hasAuthorship W3204182670A5089758540 @default.
• W3204182670 hasBestOaLocation W32041826701 @default.
• W3204182670 hasConcept C109159458 @default.
• W3204182670 hasConcept C126322002 @default.
• W3204182670 hasConcept C159654299 @default.
• W3204182670 hasConcept C203014093 @default.
• W3204182670 hasConcept C2776090121 @default.
• W3204182670 hasConcept C2777408962 @default.
• W3204182670 hasConcept C2778453870 @default.

• next