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• W3204184915 endingPage "10657" @default.
• W3204184915 startingPage "10657" @default.
• W3204184915 abstract "Neural precursors (NPs) present in the hippocampus can be modulated by several neurogenic stimuli, including environmental enrichment (EE) acting through BDNF-TrkB signaling. We have recently identified NPs in meninges; however, the meningeal niche response to pro-neurogenic stimuli has never been investigated. To this aim, we analyzed the effects of EE exposure on NP distribution in mouse brain meninges. Following neurogenic stimuli, although we did not detect modification of the meningeal cell number and proliferation, we observed an increased number of neural precursors in the meninges. A lineage tracing experiment suggested that EE-induced β3-Tubulin+ immature neuronal cells present in the meninges originated, at least in part, from GLAST+ radial glia cells. To investigate the molecular mechanism responsible for meningeal reaction to EE exposure, we studied the BDNF-TrkB interaction. Treatment with ANA-12, a TrkB non-competitive inhibitor, abolished the EE-induced meningeal niche changes. Overall, these data showed, for the first time, that EE exposure induced meningeal niche remodeling through TrkB-mediated signaling. Fluoxetine treatment further confirmed the meningeal niche response, suggesting it may also respond to other pharmacological neurogenic stimuli. A better understanding of the neurogenic stimuli modulation for meninges may be useful to improve the effectiveness of neurodegenerative and neuropsychiatric treatments." @default.
• W3204184915 created "2021-10-11" @default.
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• W3204184915 date "2021-10-01" @default.
• W3204184915 modified "2023-09-27" @default.
• W3204184915 title "Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling" @default.
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• W3204184915 doi "https://doi.org/10.3390/ijms221910657" @default.
• W3204184915 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8508649" @default.
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• W3204184915 hasPublicationYear "2021" @default.
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