Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204188844> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W3204188844 endingPage "89" @default.
- W3204188844 startingPage "79" @default.
- W3204188844 abstract "• Synthesis of novel camptothecin derivatives. • All compounds showed good in vitro cytotoxicity against five tumour cell lines. • 3D-QSAR, molecular docking to explore conformational relationships. Malignant tumors are increasing the human mortality rate year by year, so there is an urgent need to develop novel and highly effective drugs. Camptothecin (CPT) is a natural medicinal product with broad-spectrum antitumor activity. In this study, 11 CPT derivatives were synthesized. Their antitumor activities were evaluated by CCK-8, morphological observation, plate cloning, scratching, DAPI staining, cell cycle, and apoptosis. The conformational relationships were also analyzed by molecular docking and 3D-QSAR. The results showed that the CPT derivatives showed significant inhibitory effects on all five tumor cell lines, A549, HepG2, MCF-7, HemECs, and PC-3M, with the best inhibitory ability against PC-3M in prostate cancer. Among all derivatives, compound 5 had the lowest IC50 value of 0.0881 μM. In addition, compound 5 regulated the downstream cascade response by inhibiting the PI3K-Akt signaling pathway, causing cycle arrest and apoptosis. The predicted results of molecular docking and 3D-QSAR were consistent with those of the experimental group. This demonstrates the anti-tumor potential of compound 5." @default.
- W3204188844 created "2021-10-11" @default.
- W3204188844 creator A5020748132 @default.
- W3204188844 creator A5020943098 @default.
- W3204188844 creator A5031831495 @default.
- W3204188844 creator A5051463221 @default.
- W3204188844 creator A5087240893 @default.
- W3204188844 date "2021-12-01" @default.
- W3204188844 modified "2023-10-02" @default.
- W3204188844 title "Camptothecin derivatives induce apoptosis and inhibit proliferation of prostate cancer PC-3M cells through downregulation of PI3K/Akt signaling pathway" @default.
- W3204188844 cites W1969656310 @default.
- W3204188844 cites W2018185888 @default.
- W3204188844 cites W2031733136 @default.
- W3204188844 cites W2040955353 @default.
- W3204188844 cites W2073898802 @default.
- W3204188844 cites W2078235416 @default.
- W3204188844 cites W2147328441 @default.
- W3204188844 cites W4241419378 @default.
- W3204188844 doi "https://doi.org/10.1016/j.phytol.2021.08.014" @default.
- W3204188844 hasPublicationYear "2021" @default.
- W3204188844 type Work @default.
- W3204188844 sameAs 3204188844 @default.
- W3204188844 citedByCount "2" @default.
- W3204188844 countsByYear W32041888442023 @default.
- W3204188844 crossrefType "journal-article" @default.
- W3204188844 hasAuthorship W3204188844A5020748132 @default.
- W3204188844 hasAuthorship W3204188844A5020943098 @default.
- W3204188844 hasAuthorship W3204188844A5031831495 @default.
- W3204188844 hasAuthorship W3204188844A5051463221 @default.
- W3204188844 hasAuthorship W3204188844A5087240893 @default.
- W3204188844 hasConcept C104317684 @default.
- W3204188844 hasConcept C121608353 @default.
- W3204188844 hasConcept C126322002 @default.
- W3204188844 hasConcept C127561419 @default.
- W3204188844 hasConcept C185592680 @default.
- W3204188844 hasConcept C190283241 @default.
- W3204188844 hasConcept C2779682216 @default.
- W3204188844 hasConcept C2780192828 @default.
- W3204188844 hasConcept C502942594 @default.
- W3204188844 hasConcept C55493867 @default.
- W3204188844 hasConcept C62478195 @default.
- W3204188844 hasConcept C71924100 @default.
- W3204188844 hasConcept C75217442 @default.
- W3204188844 hasConcept C86554907 @default.
- W3204188844 hasConcept C86803240 @default.
- W3204188844 hasConcept C95444343 @default.
- W3204188844 hasConceptScore W3204188844C104317684 @default.
- W3204188844 hasConceptScore W3204188844C121608353 @default.
- W3204188844 hasConceptScore W3204188844C126322002 @default.
- W3204188844 hasConceptScore W3204188844C127561419 @default.
- W3204188844 hasConceptScore W3204188844C185592680 @default.
- W3204188844 hasConceptScore W3204188844C190283241 @default.
- W3204188844 hasConceptScore W3204188844C2779682216 @default.
- W3204188844 hasConceptScore W3204188844C2780192828 @default.
- W3204188844 hasConceptScore W3204188844C502942594 @default.
- W3204188844 hasConceptScore W3204188844C55493867 @default.
- W3204188844 hasConceptScore W3204188844C62478195 @default.
- W3204188844 hasConceptScore W3204188844C71924100 @default.
- W3204188844 hasConceptScore W3204188844C75217442 @default.
- W3204188844 hasConceptScore W3204188844C86554907 @default.
- W3204188844 hasConceptScore W3204188844C86803240 @default.
- W3204188844 hasConceptScore W3204188844C95444343 @default.
- W3204188844 hasLocation W32041888441 @default.
- W3204188844 hasOpenAccess W3204188844 @default.
- W3204188844 hasPrimaryLocation W32041888441 @default.
- W3204188844 hasRelatedWork W1988747615 @default.
- W3204188844 hasRelatedWork W2278983970 @default.
- W3204188844 hasRelatedWork W2362061149 @default.
- W3204188844 hasRelatedWork W2371622927 @default.
- W3204188844 hasRelatedWork W2376211306 @default.
- W3204188844 hasRelatedWork W2383760525 @default.
- W3204188844 hasRelatedWork W2603762427 @default.
- W3204188844 hasRelatedWork W3006030203 @default.
- W3204188844 hasRelatedWork W4310004300 @default.
- W3204188844 hasRelatedWork W4312127270 @default.
- W3204188844 hasVolume "46" @default.
- W3204188844 isParatext "false" @default.
- W3204188844 isRetracted "false" @default.
- W3204188844 magId "3204188844" @default.
- W3204188844 workType "article" @default.