Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204194014> ?p ?o ?g. }
- W3204194014 abstract "Abstract Many self-renewal-promoting factors of embryonic stem cells (ESCs) have been implicated in carcinogenesis, while little known about the genes that direct ESCs exit from pluripotency and regulate tumor development. Here, we show that the transcripts of Gadd45 family genes, including Gadd45a, Gadd45b, and Gadd45g, are gradually increased upon mouse ESC differentiation. Upregulation of Gadd45 members decreases cell proliferation and induces endodermal and trophectodermal lineages. In contrast, knockdown of Gadd45 genes can delay mouse ESC differentiation. Mechanistic studies reveal that Gadd45g activates MAPK signaling by increasing expression levels of the positive modulators of this pathway, such as Csf1r, Igf2, and Fgfr3. Therefore, inhibition of MAPK signaling with a MEK specific inhibitor is capable of eliminating the differentiation phenotype caused by Gadd45g upregulation. Meanwhile, GADD45G functions as a suppressor in human breast cancers. Enforced expression of GADD45G significantly inhibits tumor formation and breast cancer metastasis in mice through limitation of the propagation and invasion of breast cancer cells. These results not only expand our understanding of the regulatory network of ESCs, but also help people better treatment of cancers by manipulating the prodifferentiation candidates." @default.
- W3204194014 created "2021-10-11" @default.
- W3204194014 creator A5005730090 @default.
- W3204194014 creator A5006822602 @default.
- W3204194014 creator A5016801627 @default.
- W3204194014 creator A5037192036 @default.
- W3204194014 creator A5037552280 @default.
- W3204194014 creator A5041006918 @default.
- W3204194014 creator A5050887401 @default.
- W3204194014 creator A5052669404 @default.
- W3204194014 creator A5074140059 @default.
- W3204194014 creator A5086664284 @default.
- W3204194014 date "2021-10-02" @default.
- W3204194014 modified "2023-10-18" @default.
- W3204194014 title "Gadd45g initiates embryonic stem cell differentiation and inhibits breast cell carcinogenesis" @default.
- W3204194014 cites W1491756613 @default.
- W3204194014 cites W1596182601 @default.
- W3204194014 cites W1969795460 @default.
- W3204194014 cites W1970084119 @default.
- W3204194014 cites W1974008072 @default.
- W3204194014 cites W1975197803 @default.
- W3204194014 cites W1982331566 @default.
- W3204194014 cites W1982960471 @default.
- W3204194014 cites W1984998883 @default.
- W3204194014 cites W1989897880 @default.
- W3204194014 cites W1992160731 @default.
- W3204194014 cites W1992949513 @default.
- W3204194014 cites W1995258004 @default.
- W3204194014 cites W1995772731 @default.
- W3204194014 cites W1997982765 @default.
- W3204194014 cites W2013295681 @default.
- W3204194014 cites W2017696763 @default.
- W3204194014 cites W2018765068 @default.
- W3204194014 cites W2018848989 @default.
- W3204194014 cites W2018855387 @default.
- W3204194014 cites W2024714897 @default.
- W3204194014 cites W2034463580 @default.
- W3204194014 cites W2040174787 @default.
- W3204194014 cites W2041986831 @default.
- W3204194014 cites W2043311475 @default.
- W3204194014 cites W2045899482 @default.
- W3204194014 cites W2056749981 @default.
- W3204194014 cites W2057159461 @default.
- W3204194014 cites W2062674518 @default.
- W3204194014 cites W2064474659 @default.
- W3204194014 cites W2070420451 @default.
- W3204194014 cites W2072489106 @default.
- W3204194014 cites W2073351138 @default.
- W3204194014 cites W2076261981 @default.
- W3204194014 cites W2084888861 @default.
- W3204194014 cites W2094099211 @default.
- W3204194014 cites W2094261856 @default.
- W3204194014 cites W2094848966 @default.
- W3204194014 cites W2095513789 @default.
- W3204194014 cites W2096592632 @default.
- W3204194014 cites W2096768863 @default.
- W3204194014 cites W2104179328 @default.
- W3204194014 cites W2117961940 @default.
- W3204194014 cites W2119770631 @default.
- W3204194014 cites W2125253773 @default.
- W3204194014 cites W2130809733 @default.
- W3204194014 cites W2142122266 @default.
- W3204194014 cites W2142799999 @default.
- W3204194014 cites W2156121496 @default.
- W3204194014 cites W2163092257 @default.
- W3204194014 cites W2163606994 @default.
- W3204194014 cites W2573970795 @default.
- W3204194014 cites W2947928743 @default.
- W3204194014 cites W2954210135 @default.
- W3204194014 cites W2975324340 @default.
- W3204194014 cites W3136149345 @default.
- W3204194014 doi "https://doi.org/10.1038/s41420-021-00667-x" @default.
- W3204194014 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8487429" @default.
- W3204194014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34601500" @default.
- W3204194014 hasPublicationYear "2021" @default.
- W3204194014 type Work @default.
- W3204194014 sameAs 3204194014 @default.
- W3204194014 citedByCount "12" @default.
- W3204194014 countsByYear W32041940142022 @default.
- W3204194014 countsByYear W32041940142023 @default.
- W3204194014 crossrefType "journal-article" @default.
- W3204194014 hasAuthorship W3204194014A5005730090 @default.
- W3204194014 hasAuthorship W3204194014A5006822602 @default.
- W3204194014 hasAuthorship W3204194014A5016801627 @default.
- W3204194014 hasAuthorship W3204194014A5037192036 @default.
- W3204194014 hasAuthorship W3204194014A5037552280 @default.
- W3204194014 hasAuthorship W3204194014A5041006918 @default.
- W3204194014 hasAuthorship W3204194014A5050887401 @default.
- W3204194014 hasAuthorship W3204194014A5052669404 @default.
- W3204194014 hasAuthorship W3204194014A5074140059 @default.
- W3204194014 hasAuthorship W3204194014A5086664284 @default.
- W3204194014 hasBestOaLocation W32041940141 @default.
- W3204194014 hasConcept C104317684 @default.
- W3204194014 hasConcept C105696609 @default.
- W3204194014 hasConcept C107459253 @default.
- W3204194014 hasConcept C121608353 @default.
- W3204194014 hasConcept C127561419 @default.
- W3204194014 hasConcept C145103041 @default.
- W3204194014 hasConcept C148738053 @default.
- W3204194014 hasConcept C1491633281 @default.