FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204196368> ?p ?o ?g. }

• W3204196368 abstract "Chromosome structure and nuclear organization are important factors in the regulation of gene expression. Transcription of a gene is influenced by local and global chromosome features such as condensation status and histone modifications. The relationship between the position of a gene in the cell nucleus and its activity is less clear. Here, we used high-throughput imaging to perform a large-scale analysis of the spatial location of a set of nearly 100 hypoxia-inducible genes to determine whether their location within the nucleus is correlated with their activity state upon stimulation. Radial distance analysis demonstrated that the majority of HIF- and CREB-inducible hypoxia responsive genes are located in the intermediate region of the nucleus. Radial position of numerous responsive genes changed upon hypoxic treatment. Analysis of the relative distances amongst a subset of HIF target gene groups revealed that some gene pairs also altered their relative location to each other upon hypoxic treatment, suggesting higher order chromatin rearrangements. While these changes in location occurred in response to hypoxic activation of the target genes, they did not correlate with the extent of their activation. These results suggest that induction of the hypoxia-responsive gene expression program is accompanied by spatial alterations of the genome, but that radial and relative gene positions are not directly related to gene activity." @default.
• W3204196368 created "2021-10-11" @default.
• W3204196368 creator A5009532726 @default.
• W3204196368 creator A5020358101 @default.
• W3204196368 creator A5022561314 @default.
• W3204196368 creator A5033590861 @default.
• W3204196368 creator A5038040069 @default.
• W3204196368 creator A5054373250 @default.
• W3204196368 date "2021-09-28" @default.
• W3204196368 modified "2023-10-16" @default.
• W3204196368 title "Large-scale mapping of positional changes of hypoxia-responsive genes upon activation" @default.
• W3204196368 cites W1533179050 @default.
• W3204196368 cites W1889137377 @default.
• W3204196368 cites W1967085836 @default.
• W3204196368 cites W1968554285 @default.
• W3204196368 cites W1972495045 @default.
• W3204196368 cites W1976539942 @default.
• W3204196368 cites W1988377666 @default.
• W3204196368 cites W1998664010 @default.
• W3204196368 cites W2006311225 @default.
• W3204196368 cites W2010356452 @default.
• W3204196368 cites W2029532220 @default.
• W3204196368 cites W2038657480 @default.
• W3204196368 cites W2051518111 @default.
• W3204196368 cites W2077154575 @default.
• W3204196368 cites W2089333407 @default.
• W3204196368 cites W2100805144 @default.
• W3204196368 cites W2107665951 @default.
• W3204196368 cites W2108446493 @default.
• W3204196368 cites W2111424853 @default.
• W3204196368 cites W2143165983 @default.
• W3204196368 cites W2147758798 @default.
• W3204196368 cites W2152152724 @default.
• W3204196368 cites W2177905053 @default.
• W3204196368 cites W2185236314 @default.
• W3204196368 cites W2189671405 @default.
• W3204196368 cites W2258346454 @default.
• W3204196368 cites W2499687690 @default.
• W3204196368 cites W2552872119 @default.
• W3204196368 cites W276621466 @default.
• W3204196368 cites W2769192984 @default.
• W3204196368 cites W2778771081 @default.
• W3204196368 cites W2913787191 @default.
• W3204196368 cites W2980753870 @default.
• W3204196368 cites W3006173328 @default.
• W3204196368 cites W3093675860 @default.
• W3204196368 cites W3154810465 @default.
• W3204196368 doi "https://doi.org/10.1101/2021.09.27.462053" @default.
• W3204196368 hasPublicationYear "2021" @default.
• W3204196368 type Work @default.
• W3204196368 sameAs 3204196368 @default.
• W3204196368 citedByCount "0" @default.
• W3204196368 crossrefType "posted-content" @default.
• W3204196368 hasAuthorship W3204196368A5009532726 @default.
• W3204196368 hasAuthorship W3204196368A5020358101 @default.
• W3204196368 hasAuthorship W3204196368A5022561314 @default.
• W3204196368 hasAuthorship W3204196368A5033590861 @default.
• W3204196368 hasAuthorship W3204196368A5038040069 @default.
• W3204196368 hasAuthorship W3204196368A5054373250 @default.
• W3204196368 hasBestOaLocation W32041963681 @default.
• W3204196368 hasConcept C101762097 @default.
• W3204196368 hasConcept C104317684 @default.
• W3204196368 hasConcept C111936080 @default.
• W3204196368 hasConcept C150194340 @default.
• W3204196368 hasConcept C165864922 @default.
• W3204196368 hasConcept C2780723820 @default.
• W3204196368 hasConcept C54355233 @default.
• W3204196368 hasConcept C64927066 @default.
• W3204196368 hasConcept C83640560 @default.
• W3204196368 hasConcept C86803240 @default.
• W3204196368 hasConcept C93946551 @default.
• W3204196368 hasConcept C95444343 @default.
• W3204196368 hasConceptScore W3204196368C101762097 @default.
• W3204196368 hasConceptScore W3204196368C104317684 @default.
• W3204196368 hasConceptScore W3204196368C111936080 @default.
• W3204196368 hasConceptScore W3204196368C150194340 @default.
• W3204196368 hasConceptScore W3204196368C165864922 @default.
• W3204196368 hasConceptScore W3204196368C2780723820 @default.
• W3204196368 hasConceptScore W3204196368C54355233 @default.
• W3204196368 hasConceptScore W3204196368C64927066 @default.
• W3204196368 hasConceptScore W3204196368C83640560 @default.
• W3204196368 hasConceptScore W3204196368C86803240 @default.
• W3204196368 hasConceptScore W3204196368C93946551 @default.
• W3204196368 hasConceptScore W3204196368C95444343 @default.
• W3204196368 hasLocation W32041963681 @default.
• W3204196368 hasOpenAccess W3204196368 @default.
• W3204196368 hasPrimaryLocation W32041963681 @default.
• W3204196368 hasRelatedWork W122230838 @default.
• W3204196368 hasRelatedWork W1997510276 @default.
• W3204196368 hasRelatedWork W2025876022 @default.
• W3204196368 hasRelatedWork W2111182449 @default.
• W3204196368 hasRelatedWork W2526262876 @default.
• W3204196368 hasRelatedWork W2610197120 @default.
• W3204196368 hasRelatedWork W2799089804 @default.
• W3204196368 hasRelatedWork W2804524416 @default.
• W3204196368 hasRelatedWork W2942757851 @default.
• W3204196368 hasRelatedWork W2952178500 @default.
• W3204196368 isParatext "false" @default.
• W3204196368 isRetracted "false" @default.
• W3204196368 magId "3204196368" @default.

• next