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- W3204198119 abstract "The ethical constraints and shortcomings of animal models, combined with the demand to study disease pathogenesis under controlled conditions, are giving rise to a new field at the interface of tissue engineering and pathophysiology, which focuses on the development of in vitro models of disease. In vitro models are defined as synthetic experimental systems that contain living human cells and mimic tissue- and organ-level physiology in vitro by taking advantage of recent advances in tissue engineering and microfabrication. This review provides an overview of in vitro models and focuses specifically on in vitro disease models of the endocrine pancreas and diabetes. First, we briefly review the anatomy, physiology, and pathophysiology of the human pancreas, with an emphasis on islets of Langerhans and beta cell dysfunction. We then discuss different types of in vitro models and fundamental elements that should be considered when developing an in vitro disease model. Finally, we review the current state and breakthroughs in the field of pancreatic in vitro models and conclude with some challenges that need to be addressed in the future development of in vitro models." @default.
- W3204198119 created "2021-10-11" @default.
- W3204198119 creator A5015557827 @default.
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- W3204198119 date "2021-10-08" @default.
- W3204198119 modified "2023-10-17" @default.
- W3204198119 title "In Vitro Disease Models of the Endocrine Pancreas" @default.
- W3204198119 cites W1484201256 @default.
- W3204198119 cites W1540138335 @default.
- W3204198119 cites W1552235434 @default.
- W3204198119 cites W1832397049 @default.
- W3204198119 cites W1842274844 @default.
- W3204198119 cites W1881445774 @default.
- W3204198119 cites W1939387854 @default.
- W3204198119 cites W1965498876 @default.
- W3204198119 cites W1965975485 @default.
- W3204198119 cites W1967540288 @default.
- W3204198119 cites W1969359749 @default.
- W3204198119 cites W1969868761 @default.
- W3204198119 cites W1974345729 @default.
- W3204198119 cites W1978576423 @default.
- W3204198119 cites W1978980052 @default.
- W3204198119 cites W1979504798 @default.
- W3204198119 cites W1979665070 @default.
- W3204198119 cites W1980160627 @default.
- W3204198119 cites W1982029216 @default.
- W3204198119 cites W1983981324 @default.
- W3204198119 cites W1985112613 @default.
- W3204198119 cites W1985235027 @default.
- W3204198119 cites W1986732540 @default.
- W3204198119 cites W1987162648 @default.
- W3204198119 cites W1988665705 @default.
- W3204198119 cites W1990570289 @default.
- W3204198119 cites W1993477764 @default.
- W3204198119 cites W1994486025 @default.
- W3204198119 cites W1995599967 @default.
- W3204198119 cites W1998666012 @default.
- W3204198119 cites W1999202962 @default.
- W3204198119 cites W1999522662 @default.
- W3204198119 cites W2001607419 @default.
- W3204198119 cites W2002155653 @default.
- W3204198119 cites W2004564781 @default.
- W3204198119 cites W2005654587 @default.
- W3204198119 cites W2010292882 @default.
- W3204198119 cites W2012219406 @default.
- W3204198119 cites W2013520568 @default.
- W3204198119 cites W2016505021 @default.
- W3204198119 cites W2017801522 @default.
- W3204198119 cites W2018973124 @default.
- W3204198119 cites W2019077674 @default.
- W3204198119 cites W2021550972 @default.
- W3204198119 cites W2025909864 @default.
- W3204198119 cites W2032802439 @default.
- W3204198119 cites W2032954643 @default.
- W3204198119 cites W2034316767 @default.
- W3204198119 cites W2035259469 @default.
- W3204198119 cites W2035582064 @default.
- W3204198119 cites W2036596776 @default.
- W3204198119 cites W2039827933 @default.
- W3204198119 cites W2041652776 @default.
- W3204198119 cites W2048621454 @default.
- W3204198119 cites W2048644480 @default.
- W3204198119 cites W2048911095 @default.
- W3204198119 cites W2050274932 @default.
- W3204198119 cites W2055001415 @default.
- W3204198119 cites W2055599620 @default.
- W3204198119 cites W2056203351 @default.
- W3204198119 cites W2057508453 @default.
- W3204198119 cites W2062494925 @default.
- W3204198119 cites W2064331485 @default.
- W3204198119 cites W2064711537 @default.
- W3204198119 cites W2068892782 @default.
- W3204198119 cites W2069863598 @default.
- W3204198119 cites W2070185859 @default.
- W3204198119 cites W2071529125 @default.
- W3204198119 cites W2074869994 @default.
- W3204198119 cites W2079312215 @default.
- W3204198119 cites W2083480790 @default.
- W3204198119 cites W2086811477 @default.
- W3204198119 cites W2092316227 @default.
- W3204198119 cites W2092630986 @default.
- W3204198119 cites W2093289144 @default.
- W3204198119 cites W2094220307 @default.
- W3204198119 cites W2097167058 @default.
- W3204198119 cites W2100032374 @default.
- W3204198119 cites W2103142112 @default.
- W3204198119 cites W2106219965 @default.
- W3204198119 cites W2107512930 @default.
- W3204198119 cites W2112136221 @default.
- W3204198119 cites W2116475082 @default.
- W3204198119 cites W2117961743 @default.
- W3204198119 cites W2124025841 @default.