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• W3204199074 abstract "Most photosensitizers (PS) suffer from a lack of water solubility and from a low selectivity toward tumor cells. Delivery systems using nanoparticles make it possible to improve PS water solubility, and also tumor targeting via the enhanced permeability and retention (EPR) effect. Among the organelles, mitochondria are attractive target sites for drug-delivery strategies since they perform a variety of key cellular processes. Our study was aimed at synthesizing nanoparticles consisting of xylan-carrying porphyrins attached to a triphenylphosphonium moiety, in order to enhance the PDT effect through mitochondrial targeting. Hybrid nanoparticles were designed that consisted of a silica core coated with xylan substituted with porphyrin derivatives carrying a triphenylphosphonium moiety. These hybrid nanoparticles have been constructed, along with their counterparts devoid of silica core, taking into consideration the controversy surrounding the use of silica nanoparticles. Phototoxicity experiments, conducted against the HCT-116 and HT-29 colorectal cancer cell lines, showed that nanoparticles with porphyrins bearing a triphenylphosphonium moiety exhibited an enhanced photocytotoxic effect in comparison with free porphyrin or nanoparticles with porphyrins without the triphenylphosphonium moiety. Supplementary Materials: Supplementary material for this article is supplied as a separate file: crchim-108-suppl.pdf La plupart des photosensibilisateurs (PS) souffrent d’un manque de solubilité dans l’eau et d’une faible sélectivité envers les cellules tumorales. Les systèmes d’administration utilisant des nanoparticules permettent à la fois d’améliorer la solubilité dans l’eau du PS, ainsi que le ciblage des tumeurs via l’effet EPR. Parmi les organites, les mitochondries sont des cibles de choix pour les stratégies d’administration de médicaments puisqu’elles sont essentielles au fonctionnement cellulaire. Notre étude a pour objectif de synthétiser des nanoparticules constituées de xylane portant des porphyrines avec un groupement triphénylphosphonium, afin d’améliorer l’effet PDT grâce au ciblage mitochondrial. Des nanoparticules hybrides, constituées d’un cœur de silice recouvert de xylane substitué par des dérivés de porphyrine portant un groupement triphénylphosphonium ont été préparées ainsi que leurs homologues dépourvues du cœur inorganique. Des expériences de phototoxicité, menées sur les lignées cellulaires des cancers colorectaux HCT-116 et HT-29, ont montré que les nanoparticules avec des porphyrines portant un groupement triphénylphosphonium présentaient une photocytotoxicité plus importante que la porphyrine libre ou les nanoparticules avec des porphyrines sans groupement triphénylphosphonium. Compléments : Des compléments sont fournis pour cet article dans le fichier séparé : crchim-108-suppl.pdf" @default.
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• W3204199074 date "2021-09-23" @default.
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• W3204199074 title "Design and synthesis of triphenylphosphonium-porphyrin@xylan nanoparticles for anticancer photodynamic therapy" @default.
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• W3204199074 doi "https://doi.org/10.5802/crchim.108" @default.
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