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• W3204199503 endingPage "101183" @default.
• W3204199503 startingPage "101183" @default.
• W3204199503 abstract "• Emerging supported lipid bilayer (SLB) fabrication strategies are presented. • Many bioconjugation strategies exist for protein attachment to lipid bilayers. • SLB platforms are useful for circulating tumor cell (CTC) detection. • Clinical lab testing demonstrates excellent possibilities for cancer diagnosis. Supported lipid bilayer (SLB) coatings are versatile, cell-membrane-mimicking biointerfaces that are useful for fundamental biophysical studies and for various applications such as biosensors, diagnostics, and antifouling surfaces. However, until recently, SLB research was mainly limited to niche interfacial science research communities and ongoing material science advances have expanded the fabrication ease, scalability, and utility of SLB platforms for medical and biotechnology applications. Herein, we critically discuss ongoing progress in SLB fabrication, bioconjugation, and diagnostic applications, with particular focus on clinical-stage circulating tumor cell (CTC) detection for cancer diagnosis. A comprehensive overview of conventional and emerging SLB fabrication methods is provided along with different bioconjugation strategies to attach biomacromolecules such as proteins to SLB surfaces for molecular recognition purposes. We then examine how antibody-functionalized SLB platforms are being utilized for CTC detection and introduce clinical application examples. Future trends and application possibilities are also projected and demonstrate how SLB coatings are evolving into a robust surface functionalization option for endowing sensor surfaces with biomimetic functionalities. Supported lipid bilayer (SLB) coatings are enabling a new class of medical diagnostics based on multifunctional properties for antifouling and selective cell capture. Recent progress has focused on circulating tumor cell detection for cancer diagnostics, an application which is now reaching clinical laboratory use and opening the door to many possibilities." @default.
• W3204199503 created "2021-10-11" @default.
• W3204199503 creator A5017710551 @default.
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• W3204199503 creator A5087948924 @default.
• W3204199503 date "2021-12-01" @default.
• W3204199503 modified "2023-10-08" @default.
• W3204199503 title "Supported lipid bilayer coatings: Fabrication, bioconjugation, and diagnostic applications" @default.
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