Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204199705> ?p ?o ?g. }
- W3204199705 abstract "Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant cancers. It is characterized by a poor prognosis with a 5-year survival rate of only around 10% and an ongoing increase in death rate. Due to the lack of early and specific symptoms, most patients are diagnosed at an advanced or even metastasized stage, essentially limiting curative treatment options. However, even curative resection of the primary tumor and adjuvant therapy often fails to provide a long-term survival benefit. One reason for this dismal situation can be seen in the evolution of therapy resistances. Furthermore, PDAC is characterized by high intratumor heterogeneity, pointing towards an abundance of cancer stem cells (CSCs), which are regarded as essential for tumor initiation and drug resistance. Additionally, it was shown that the gut microbiome is altered in PDAC patients, promotes Epithelial-Mesenchymal-Transition (EMT), determines responses towards chemotherapy, and affects survival in PDAC patients. Given the established links between CSCs and EMT as well as drug resistance, and the emerging role of the microbiome in PDAC, we postulate that the composition of the microbiome of PDAC patients is a critical determinant for the abundance and plasticity of CSC populations and thus tumor heterogeneity in PDAC. Unravelling this complex interplay might pave the way for novel treatment strategies." @default.
- W3204199705 created "2021-10-11" @default.
- W3204199705 creator A5010406582 @default.
- W3204199705 creator A5011621128 @default.
- W3204199705 creator A5042457459 @default.
- W3204199705 creator A5067185465 @default.
- W3204199705 date "2021-09-23" @default.
- W3204199705 modified "2023-10-12" @default.
- W3204199705 title "The Microbiome Tumor Axis: How the Microbiome Could Contribute to Clonal Heterogeneity and Disease Outcome in Pancreatic Cancer" @default.
- W3204199705 cites W1906647682 @default.
- W3204199705 cites W1935464246 @default.
- W3204199705 cites W1968812902 @default.
- W3204199705 cites W1979342940 @default.
- W3204199705 cites W1998708130 @default.
- W3204199705 cites W2004878973 @default.
- W3204199705 cites W2014691022 @default.
- W3204199705 cites W2017627540 @default.
- W3204199705 cites W2021479489 @default.
- W3204199705 cites W2037961348 @default.
- W3204199705 cites W2051615139 @default.
- W3204199705 cites W2058400226 @default.
- W3204199705 cites W2058468989 @default.
- W3204199705 cites W2061965920 @default.
- W3204199705 cites W2063262427 @default.
- W3204199705 cites W2070577306 @default.
- W3204199705 cites W2078900549 @default.
- W3204199705 cites W2080320008 @default.
- W3204199705 cites W2080797874 @default.
- W3204199705 cites W2085284704 @default.
- W3204199705 cites W2090925778 @default.
- W3204199705 cites W2117692326 @default.
- W3204199705 cites W2123216084 @default.
- W3204199705 cites W2124632458 @default.
- W3204199705 cites W2125983095 @default.
- W3204199705 cites W2131170195 @default.
- W3204199705 cites W2138276717 @default.
- W3204199705 cites W2146616032 @default.
- W3204199705 cites W2148128131 @default.
- W3204199705 cites W2151948621 @default.
- W3204199705 cites W2158811570 @default.
- W3204199705 cites W2165456770 @default.
- W3204199705 cites W2169330513 @default.
- W3204199705 cites W2181521389 @default.
- W3204199705 cites W2185075416 @default.
- W3204199705 cites W2260497668 @default.
- W3204199705 cites W2490991344 @default.
- W3204199705 cites W2553024592 @default.
- W3204199705 cites W2586407709 @default.
- W3204199705 cites W2590119509 @default.
- W3204199705 cites W2604819175 @default.
- W3204199705 cites W2756403351 @default.
- W3204199705 cites W2763367287 @default.
- W3204199705 cites W2770805807 @default.
- W3204199705 cites W2778416039 @default.
- W3204199705 cites W2782333299 @default.
- W3204199705 cites W2787016559 @default.
- W3204199705 cites W2790589159 @default.
- W3204199705 cites W2799722465 @default.
- W3204199705 cites W2886231942 @default.
- W3204199705 cites W2899325889 @default.
- W3204199705 cites W2899852374 @default.
- W3204199705 cites W2900706315 @default.
- W3204199705 cites W2911297768 @default.
- W3204199705 cites W2913836031 @default.
- W3204199705 cites W2921125196 @default.
- W3204199705 cites W2933324386 @default.
- W3204199705 cites W2947924265 @default.
- W3204199705 cites W2964688507 @default.
- W3204199705 cites W2967450000 @default.
- W3204199705 cites W2967686606 @default.
- W3204199705 cites W2973943668 @default.
- W3204199705 cites W2981269989 @default.
- W3204199705 cites W2993453774 @default.
- W3204199705 cites W3000550798 @default.
- W3204199705 cites W3023906975 @default.
- W3204199705 cites W3039180268 @default.
- W3204199705 cites W3108061967 @default.
- W3204199705 cites W3119005666 @default.
- W3204199705 cites W3119973424 @default.
- W3204199705 cites W3194153866 @default.
- W3204199705 cites W3195264720 @default.
- W3204199705 cites W4211233744 @default.
- W3204199705 doi "https://doi.org/10.3389/fonc.2021.740606" @default.
- W3204199705 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8495218" @default.
- W3204199705 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34631577" @default.
- W3204199705 hasPublicationYear "2021" @default.
- W3204199705 type Work @default.
- W3204199705 sameAs 3204199705 @default.
- W3204199705 citedByCount "5" @default.
- W3204199705 countsByYear W32041997052022 @default.
- W3204199705 countsByYear W32041997052023 @default.
- W3204199705 crossrefType "journal-article" @default.
- W3204199705 hasAuthorship W3204199705A5010406582 @default.
- W3204199705 hasAuthorship W3204199705A5011621128 @default.
- W3204199705 hasAuthorship W3204199705A5042457459 @default.
- W3204199705 hasAuthorship W3204199705A5067185465 @default.
- W3204199705 hasBestOaLocation W32041997051 @default.
- W3204199705 hasConcept C113968399 @default.
- W3204199705 hasConcept C121608353 @default.
- W3204199705 hasConcept C126322002 @default.