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- W3204200293 abstract "The conserved Hippo signaling pathway plays an important role in limiting tissue growth by controlling proliferation rates. The core of the pathway is composed of STK3/4 and LATS1/2 kinases, which restrict the activity of YAP1, the main downstream effector. Upstream, the pathway is controlled by polarity proteins, other kinases, receptors, and scaffolding proteins. We conducted a split TEV-based protein-protein interaction screen to evaluate physical interactions among major Hippo pathway components and potential upstream modulators. TAOK2 was identified as key modulator of Hippo signaling, binding to pathway core kinase cassette components. Especially, TAOK2 binds to and phosphorylates LATS1, regulating YAP1 phosphorylation states, YAP1 transcriptional activity, and the proliferation of HEK293 cells. In a subset of human cancers, reduced TAOK2 expression correlates with reduced patient survival time supporting TAOK2’s role as tumor suppressor gene. As TAOK2 is a principally druggable kinase, it represents an attractive pharmacological target to modulate growth." @default.
- W3204200293 created "2021-10-11" @default.
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- W3204200293 date "2021-01-01" @default.
- W3204200293 modified "2023-09-27" @default.
- W3204200293 title "Comprehensive Split TEV Based Protein-Protein Interaction Screening of the Hippo Signaling Pathway Identifies TAOK2 As Central Modulator" @default.
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- W3204200293 doi "https://doi.org/10.2139/ssrn.3933991" @default.
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