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- W3204200467 abstract "The biological function of glycosaminoglycan (GAG) oligosaccharides is dictated in part by the pattern of modifications (sulfation, acetylation/deacetylation, and epimerization of uronic acids) occurring in oligosaccharide regions of the polysaccharide. The sequencing of the pattern of modifications of glycosaminoglycan (GAG) oligosaccharides is highly challenging due to the heterogeneity of most naturally occurring GAGs. While liquid chromatography coupled with mass spectrometry (LC-MS) is widely used to determine GAG oligosaccharide composition, the high lability of sulfates in the gas phase makes structural interrogation by tandem mass spectrometry (MS/MS) unlikely to yield useful sequence information. Here we describe a method for the chemical derivatization of GAG oligosaccharides that replaces sulfate groups in a site-specific manner. The resulting derivatized GAG oligosaccharides can be chromatographically separated with high efficiency using C18 reversed-phase chromatography and sequenced using standard LC-MS/MS methods." @default.
- W3204200467 created "2021-10-11" @default.
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- W3204200467 date "2021-10-10" @default.
- W3204200467 modified "2023-09-26" @default.
- W3204200467 title "De Novo Sequencing of Heparin/Heparan by Chemical Derivatization and LC-MS/MS" @default.
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- W3204200467 doi "https://doi.org/10.1007/978-1-0716-1398-6_14" @default.
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