FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204201847> ?p ?o ?g. }

• W3204201847 abstract "The goal of this investigation was to determine whether there are alterations in DNA methylation patterns in children with autism spectrum disorder (ASD). Material and Methods: Controlled prospective observational case-control study. Within the ASD group, children were sub-classified based on the presence (AMR subgroup) or absence (ANMR subgroup) of neurodevelopmental regression during the first 2 years of life. We analyzed the global levels of DNA methylation, reflected in LINE-1, and the local DNA methylation pattern in two candidate genes, Neural Cell Adhesion Molecule (NCAM1) and Nerve Growth Factor (NGF) that, according to our previous studies, might be associated to an increased risk for ASD. For this purpose, we utilized blood samples from pediatric patients with ASD (n = 53) and their corresponding controls (n = 45). Results: We observed a slight decrease in methylation levels of LINE-1 in the ASD group, compared to the control group. One of the CpG in LINE-1 (GenBank accession no.X58075, nucleotide position 329) was the main responsible for such reduction, highly significant in the ASD subgroup of children with AMR (p < 0.05). Furthermore, we detected higher NCAM1 methylation levels in ASD children, compared to healthy children (p < 0.001). The data, moreover, showed higher NGF methylation levels in the AMR subgroup, compared to the control group and the ANMR subgroup. These results are consistent with our prior study, in which lower plasma levels of NCAM1 and higher levels of NGF were found in the ANMR subgroup, compared to the subgroup that comprised neurotypically developing children. Conclusions: We have provided new clues about the epigenetic changes that occur in ASD, and suggest two potential epigenetic biomarkers that would facilitate the diagnosis of the disorder. We similarly present with evidence of a clear differentiation in DNA methylation between the ASD subgroups, with or without mental regression." @default.
• W3204201847 created "2021-10-11" @default.
• W3204201847 creator A5016707862 @default.
• W3204201847 creator A5021038143 @default.
• W3204201847 creator A5021635121 @default.
• W3204201847 creator A5023550343 @default.
• W3204201847 creator A5034826184 @default.
• W3204201847 creator A5046403679 @default.
• W3204201847 creator A5049593983 @default.
• W3204201847 creator A5057641249 @default.
• W3204201847 creator A5074816723 @default.
• W3204201847 creator A5078523805 @default.
• W3204201847 date "2021-10-05" @default.
• W3204201847 modified "2023-10-18" @default.
• W3204201847 title "Analysis of Global and Local DNA Methylation Patterns in Blood Samples of Patients With Autism Spectrum Disorder" @default.
• W3204201847 cites W1531488652 @default.
• W3204201847 cites W1921561313 @default.
• W3204201847 cites W1969637353 @default.
• W3204201847 cites W1981262837 @default.
• W3204201847 cites W1999064519 @default.
• W3204201847 cites W2007432181 @default.
• W3204201847 cites W2020388524 @default.
• W3204201847 cites W2051541780 @default.
• W3204201847 cites W2052350723 @default.
• W3204201847 cites W2052689749 @default.
• W3204201847 cites W2066612090 @default.
• W3204201847 cites W2108994842 @default.
• W3204201847 cites W2114924552 @default.
• W3204201847 cites W2123032740 @default.
• W3204201847 cites W2123739801 @default.
• W3204201847 cites W2127611401 @default.
• W3204201847 cites W2127869286 @default.
• W3204201847 cites W2130907138 @default.
• W3204201847 cites W2138509390 @default.
• W3204201847 cites W2145850516 @default.
• W3204201847 cites W2146527331 @default.
• W3204201847 cites W2146915584 @default.
• W3204201847 cites W2149522457 @default.
• W3204201847 cites W2308244787 @default.
• W3204201847 cites W2346624014 @default.
• W3204201847 cites W2412698662 @default.
• W3204201847 cites W2433808072 @default.
• W3204201847 cites W2559787107 @default.
• W3204201847 cites W2590099042 @default.
• W3204201847 cites W2616162660 @default.
• W3204201847 cites W2734776945 @default.
• W3204201847 cites W2743718080 @default.
• W3204201847 cites W2801576086 @default.
• W3204201847 cites W2884729712 @default.
• W3204201847 cites W2893521709 @default.
• W3204201847 cites W2899654106 @default.
• W3204201847 cites W2909735684 @default.
• W3204201847 cites W2912155724 @default.
• W3204201847 cites W3014767518 @default.
• W3204201847 doi "https://doi.org/10.3389/fped.2021.685310" @default.
• W3204201847 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8524094" @default.
• W3204201847 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34676183" @default.
• W3204201847 hasPublicationYear "2021" @default.
• W3204201847 type Work @default.
• W3204201847 sameAs 3204201847 @default.
• W3204201847 citedByCount "10" @default.
• W3204201847 countsByYear W32042018472022 @default.
• W3204201847 countsByYear W32042018472023 @default.
• W3204201847 crossrefType "journal-article" @default.
• W3204201847 hasAuthorship W3204201847A5016707862 @default.
• W3204201847 hasAuthorship W3204201847A5021038143 @default.
• W3204201847 hasAuthorship W3204201847A5021635121 @default.
• W3204201847 hasAuthorship W3204201847A5023550343 @default.
• W3204201847 hasAuthorship W3204201847A5034826184 @default.
• W3204201847 hasAuthorship W3204201847A5046403679 @default.
• W3204201847 hasAuthorship W3204201847A5049593983 @default.
• W3204201847 hasAuthorship W3204201847A5057641249 @default.
• W3204201847 hasAuthorship W3204201847A5074816723 @default.
• W3204201847 hasAuthorship W3204201847A5078523805 @default.
• W3204201847 hasBestOaLocation W32042018471 @default.
• W3204201847 hasConcept C104317684 @default.
• W3204201847 hasConcept C118552586 @default.
• W3204201847 hasConcept C126322002 @default.
• W3204201847 hasConcept C140173407 @default.
• W3204201847 hasConcept C150194340 @default.
• W3204201847 hasConcept C187960798 @default.
• W3204201847 hasConcept C190727270 @default.
• W3204201847 hasConcept C205778803 @default.
• W3204201847 hasConcept C2778538070 @default.
• W3204201847 hasConcept C33288867 @default.
• W3204201847 hasConcept C44249647 @default.
• W3204201847 hasConcept C54355233 @default.
• W3204201847 hasConcept C71924100 @default.
• W3204201847 hasConcept C79029880 @default.
• W3204201847 hasConcept C86803240 @default.
• W3204201847 hasConceptScore W3204201847C104317684 @default.
• W3204201847 hasConceptScore W3204201847C118552586 @default.
• W3204201847 hasConceptScore W3204201847C126322002 @default.
• W3204201847 hasConceptScore W3204201847C140173407 @default.
• W3204201847 hasConceptScore W3204201847C150194340 @default.
• W3204201847 hasConceptScore W3204201847C187960798 @default.
• W3204201847 hasConceptScore W3204201847C190727270 @default.
• W3204201847 hasConceptScore W3204201847C205778803 @default.
• W3204201847 hasConceptScore W3204201847C2778538070 @default.
• W3204201847 hasConceptScore W3204201847C33288867 @default.

• next