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- W3204209081 endingPage "131573" @default.
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- W3204209081 abstract "The β-diketone derivatives in plants exhibit biological activity due to tautomerism and extended conjugation with the aromatic ring system. β-diketone derivatives; (Z)-3-(4-(4-aminophenoxy)phenylamino)-1,3-diphenylprop-2-en-1-one(L1) and (2Z,2′Z)-3,3′-(4,4′-oxybis(4,1-phenylene)bis(azanediyl)bis (1,3-diphenylprop-2-en-1-one(L2) were synthesized and characterized by spectral and single-crystal XRD analysis illustrate the compounds are in ketamine form. The study assessed the cytotoxicity and apoptotic effect of L1 and L2 and similar ketamines against human breast cancer (MCF 7) cell lines. The compounds showed selective inhibitory activity against the breast cancer cell lines. Interestingly, L1 and L2 bearing extended conjugation through –O linkage exhibit higher anticancer activity with inhibitory concentration values (IC50) comparable with the standard drug (Tamoxifen). Further investigations using DCFH-DA and DAPI staining assay revealed the compounds induce cell apoptosis by producing intracellular Reactive Oxygen Species (ROS). To further investigate, the binding attribute of L1-L4 with CT DNA was assessed, and the compounds were docked with DNA duplex of sequence, d(CGCGAATTCGCG)2 and breast cancer protease (3EU7)." @default.
- W3204209081 created "2021-10-11" @default.
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- W3204209081 date "2022-02-01" @default.
- W3204209081 modified "2023-10-14" @default.
- W3204209081 title "Polyaromatic ring containing β-diketone derivatives with antiproliferative activity toward human breast cancer cell lines: Synthesis, structure, DNA binding and molecular docking" @default.
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- W3204209081 doi "https://doi.org/10.1016/j.molstruc.2021.131573" @default.
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