Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204218909> ?p ?o ?g. }
- W3204218909 endingPage "2008" @default.
- W3204218909 startingPage "2008" @default.
- W3204218909 abstract "Direct-acting antivirals (DAAs) are used for hepatitis C virus (HCV) treatment. However, treatment failure and hepatocellular carcinoma (HCC) development following treatment was reported. In this study, we assessed the role of serum vitamin D, interleukin 13 (IL-13), and microRNA-135a in the prediction of treatment failure with DAA and HCC development among Egyptian HCV-infected patients. A total of 950 patients with HCV-related chronic liver disease underwent DAA treatment. Before DAAs, serum vitamin D and IL-13 were determined by ELISA, and gene expression of miRNA-135a was assessed in serum by real-time PCR. The predictive abilities of these markers were determined using the receiver operating characteristic (ROC) curve. Sustained virological response (SVR) was achieved in 92.6% of HCV-infected patients (responders). High viral load, IL-13, miRNA-135a, and low vitamin D levels were associated with treatment failure and HCC development. HCC development was recorded in non-responders, but not in the responders (35.7% vs. 0% p < 0.001). In conclusion: serum IL-13, Vitamin D, and miRNA-135a could be potential biomarkers in monitoring DAA treatment and HCC prediction. DAAs-induced SVR may decrease the incidence of HCC." @default.
- W3204218909 created "2021-10-11" @default.
- W3204218909 creator A5001413363 @default.
- W3204218909 creator A5007575250 @default.
- W3204218909 creator A5014707343 @default.
- W3204218909 creator A5026841785 @default.
- W3204218909 creator A5033784030 @default.
- W3204218909 creator A5044574607 @default.
- W3204218909 creator A5053492154 @default.
- W3204218909 creator A5056197282 @default.
- W3204218909 creator A5056318502 @default.
- W3204218909 creator A5091017396 @default.
- W3204218909 date "2021-10-06" @default.
- W3204218909 modified "2023-09-27" @default.
- W3204218909 title "Role of Serum Vitamin D, Interleukin 13, and microRNA-135a in Hepatocellular Carcinoma and Treatment Failure in Egyptian HCV-Infected Patients Receiving Direct Antiviral Agents" @default.
- W3204218909 cites W1199211172 @default.
- W3204218909 cites W1578939031 @default.
- W3204218909 cites W1922890115 @default.
- W3204218909 cites W1970653213 @default.
- W3204218909 cites W1972232097 @default.
- W3204218909 cites W1974582160 @default.
- W3204218909 cites W1979111436 @default.
- W3204218909 cites W1980220254 @default.
- W3204218909 cites W1980771473 @default.
- W3204218909 cites W1983793392 @default.
- W3204218909 cites W1985160576 @default.
- W3204218909 cites W1988800192 @default.
- W3204218909 cites W2000336618 @default.
- W3204218909 cites W2014361783 @default.
- W3204218909 cites W2018836323 @default.
- W3204218909 cites W2020914906 @default.
- W3204218909 cites W2026053082 @default.
- W3204218909 cites W2026216011 @default.
- W3204218909 cites W2026891932 @default.
- W3204218909 cites W2039537887 @default.
- W3204218909 cites W2045073898 @default.
- W3204218909 cites W2047033934 @default.
- W3204218909 cites W2049907246 @default.
- W3204218909 cites W2061357996 @default.
- W3204218909 cites W2071418772 @default.
- W3204218909 cites W2078251659 @default.
- W3204218909 cites W2087315392 @default.
- W3204218909 cites W2092951995 @default.
- W3204218909 cites W2094972821 @default.
- W3204218909 cites W2096511773 @default.
- W3204218909 cites W2098279581 @default.
- W3204218909 cites W2100529541 @default.
- W3204218909 cites W2102792873 @default.
- W3204218909 cites W2102942095 @default.
- W3204218909 cites W2107986225 @default.
- W3204218909 cites W2112004022 @default.
- W3204218909 cites W2113864802 @default.
- W3204218909 cites W2113996486 @default.
- W3204218909 cites W2118217096 @default.
- W3204218909 cites W2122253936 @default.
- W3204218909 cites W2148840656 @default.
- W3204218909 cites W2150295966 @default.
- W3204218909 cites W2152629323 @default.
- W3204218909 cites W2154066696 @default.
- W3204218909 cites W2162661249 @default.
- W3204218909 cites W2165275185 @default.
- W3204218909 cites W2167289017 @default.
- W3204218909 cites W2168076454 @default.
- W3204218909 cites W2168938667 @default.
- W3204218909 cites W2172039243 @default.
- W3204218909 cites W2191957520 @default.
- W3204218909 cites W2262890972 @default.
- W3204218909 cites W2277004004 @default.
- W3204218909 cites W2289667014 @default.
- W3204218909 cites W2294421604 @default.
- W3204218909 cites W2301065617 @default.
- W3204218909 cites W2306227468 @default.
- W3204218909 cites W2314397275 @default.
- W3204218909 cites W2323198845 @default.
- W3204218909 cites W2335913920 @default.
- W3204218909 cites W2410976255 @default.
- W3204218909 cites W2429522722 @default.
- W3204218909 cites W2464119169 @default.
- W3204218909 cites W2467713285 @default.
- W3204218909 cites W2503874329 @default.
- W3204218909 cites W2507468503 @default.
- W3204218909 cites W2520869351 @default.
- W3204218909 cites W2540370990 @default.
- W3204218909 cites W2554990572 @default.
- W3204218909 cites W2569515399 @default.
- W3204218909 cites W2578166624 @default.
- W3204218909 cites W2583985389 @default.
- W3204218909 cites W2594752891 @default.
- W3204218909 cites W2605644052 @default.
- W3204218909 cites W2737409822 @default.
- W3204218909 cites W2751505630 @default.
- W3204218909 cites W2763164181 @default.
- W3204218909 cites W2764036389 @default.
- W3204218909 cites W2765110984 @default.
- W3204218909 cites W2767749078 @default.
- W3204218909 cites W2769117260 @default.
- W3204218909 cites W2769758977 @default.
- W3204218909 cites W2771057425 @default.