FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204222225> ?p ?o ?g. }

• W3204222225 endingPage "14" @default.
• W3204222225 startingPage "1" @default.
• W3204222225 abstract "Background. Conflicting results exist between the potential protective effects of metformin and the prognosis of urologic cancers. This meta-analysis summarized the effects of metformin exposure on the recurrence, progression, cancer-specific survival (CSS), and overall survival (OS) of the three main urologic cancers (kidney cancer, bladder cancer, and prostate cancer). Methods. We systematically searched PubMed, Embase, Web of Science, Wanfang, and China National Knowledge Infrastructure databases (January 2010 to December 2019), which identified studies regarding metformin users and nonusers with urologic cancers and extracted patient data. A random effect model or fixed effect model was used to analyze hazard ratios (HRs) and 95% confidence intervals (CIs). Results. Among the 1883 confirmed studies, 27 eligible studies were identified, including 123,212 participants. In prostate cancer, patients using metformin have significant benefits for recurrence ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mtext>HR</mtext> <mo>=</mo> <mn>0.74</mn> </math> ; 95% CI: 0.61-0.90; <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>P</mi> <mo>=</mo> <mn>0.007</mn> </math> ; <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <msup> <mrow> <mi>I</mi> </mrow> <mrow> <mn>2</mn> </mrow> </msup> <mo>=</mo> <mn>56</mn> <mi>%</mi> </math> ), CSS ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mtext>HR</mtext> <mo>=</mo> <mn>0.74</mn> </math> ; 95% CI: 0.61-0.91; <math xmlns=http://www.w3.org/1998/Math/MathML id=M5> <mi>P</mi> <mo>=</mo> <mn>0.002</mn> </math> ; <math xmlns=http://www.w3.org/1998/Math/MathML id=M6> <msup> <mrow> <mi>I</mi> </mrow> <mrow> <mn>2</mn> </mrow> </msup> <mo>=</mo> <mn>79</mn> <mi>%</mi> </math> ), and OS ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M7> <mtext>HR</mtext> <mo>=</mo> <mn>0.76</mn> </math> ; 95% CI: 0.65-0.90; <math xmlns=http://www.w3.org/1998/Math/MathML id=M8> <mi>P</mi> <mo><</mo> <mn>0.001</mn> </math> ; <math xmlns=http://www.w3.org/1998/Math/MathML id=M9> <msup> <mrow> <mi>I</mi> </mrow> <mrow> <mn>2</mn> </mrow> </msup> <mo>=</mo> <mn>86</mn> <mi>%</mi> </math> ). Moreover, further subgroup analysis showed that the beneficial effects of metformin may be more significant for patients receiving radical radiotherapy. For kidney cancer, metformin was beneficial for progression ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M10> <mtext>HR</mtext> <mo>=</mo> <mn>0.80</mn> </math> ; 95% CI: 0.65-0.98; <math xmlns=http://www.w3.org/1998/Math/MathML id=M11> <mi>P</mi> <mo>=</mo> <mn>0.14</mn> </math> ; <math xmlns=http://www.w3.org/1998/Math/MathML id=M12> <msup> <mrow> <mi>I</mi> </mrow> <mrow> <mn>2</mn> </mrow> </msup> <mo>=</mo> <mn>46</mn> <mi>%</mi> </math> ). Analysis revealed that the effect of metformin on the overall survival of kidney cancer patients may be related to nationality (American: <math xmlns=http://www.w3.org/1998/Math/MathML id=M13> <mtext>HR</mtext> <mo>=</mo> <mn>0.76</mn> </math> ; 95% CI: 0.59-0.98; <math xmlns=http://www.w3.org/1998/Math/MathML id=M14> <mi>P</mi> <mo>=</mo> <mn>0.88</mn> </math> ; <math xmlns=http://www.w3.org/1998/Math/MathML id=M15> <msup> <mrow> <mi>I</mi> </mrow> <mrow> <mn>2</mn> </mrow> </msup> <mo>=</mo> <mn>0</mn> <mi>%</mi> </math> ). For bladder cancer, no obvious benefits of metformin use were identified. However, subgroup analysis indicated that metformin may improve the recurrence of bladder cancer, but this improvement was only found in patients with a median follow-up time of more than 4 years ( <math xmlns=http://www.w3.org/1998/Math/MathML id=M16> <mtext>HR</mtext> <mo>=</mo> <mn>0.43</mn> </math> ; 95% CI: 0.28-0.67; <math xmlns=http://www.w3.org/1998/Math/MathML id=M17> <mi>P</mi> <mo>=</mo> <mn>0.61</mn> </math> ; <math xmlns=http://www.w3.org/1998/Math/MathML id=M18> <msup> <mrow> <mi>I</mi> </mrow> <mrow> <mn>2</mn> </mrow> </msup> <mo>=</mo> <mn>0</mn> <mi>%</mi> </math> )." @default.
• W3204222225 created "2021-10-11" @default.
• W3204222225 creator A5056454004 @default.
• W3204222225 creator A5082086115 @default.
• W3204222225 creator A5084072550 @default.
• W3204222225 date "2021-10-08" @default.
• W3204222225 modified "2023-10-14" @default.
• W3204222225 title "The Impact of Metformin Use with Survival Outcomes in Urologic Cancers: A Systematic Review and Meta-Analysis" @default.
• W3204222225 cites W1518093922 @default.
• W3204222225 cites W1818173544 @default.
• W3204222225 cites W1896360033 @default.
• W3204222225 cites W1964760331 @default.
• W3204222225 cites W1984716297 @default.
• W3204222225 cites W1992786512 @default.
• W3204222225 cites W1995734875 @default.
• W3204222225 cites W2017035350 @default.
• W3204222225 cites W2020267609 @default.
• W3204222225 cites W2025874220 @default.
• W3204222225 cites W2044428844 @default.
• W3204222225 cites W2048994966 @default.
• W3204222225 cites W2052384472 @default.
• W3204222225 cites W2055249407 @default.
• W3204222225 cites W2057218469 @default.
• W3204222225 cites W2059116757 @default.
• W3204222225 cites W2064656431 @default.
• W3204222225 cites W2074889838 @default.
• W3204222225 cites W2076582761 @default.
• W3204222225 cites W2076643714 @default.
• W3204222225 cites W2085331940 @default.
• W3204222225 cites W2092354903 @default.
• W3204222225 cites W2096315962 @default.
• W3204222225 cites W2118038328 @default.
• W3204222225 cites W2125435699 @default.
• W3204222225 cites W2126646540 @default.
• W3204222225 cites W2135902771 @default.
• W3204222225 cites W2137424322 @default.
• W3204222225 cites W2146511561 @default.
• W3204222225 cites W2146654374 @default.
• W3204222225 cites W2148672071 @default.
• W3204222225 cites W2148710188 @default.
• W3204222225 cites W2149179641 @default.
• W3204222225 cites W2150000105 @default.
• W3204222225 cites W2161701454 @default.
• W3204222225 cites W2162681994 @default.
• W3204222225 cites W2164976843 @default.
• W3204222225 cites W2167436791 @default.
• W3204222225 cites W2218363463 @default.
• W3204222225 cites W2285738189 @default.
• W3204222225 cites W2404104112 @default.
• W3204222225 cites W2462101286 @default.
• W3204222225 cites W2462521029 @default.
• W3204222225 cites W2481386596 @default.
• W3204222225 cites W2508488166 @default.
• W3204222225 cites W2521859216 @default.
• W3204222225 cites W2524637936 @default.
• W3204222225 cites W2552576917 @default.
• W3204222225 cites W2593712675 @default.
• W3204222225 cites W2809237761 @default.
• W3204222225 cites W2912542243 @default.
• W3204222225 cites W2987435124 @default.
• W3204222225 doi "https://doi.org/10.1155/2021/5311828" @default.
• W3204222225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8519697" @default.
• W3204222225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34660791" @default.
• W3204222225 hasPublicationYear "2021" @default.
• W3204222225 type Work @default.
• W3204222225 sameAs 3204222225 @default.
• W3204222225 citedByCount "4" @default.
• W3204222225 countsByYear W32042222252022 @default.
• W3204222225 countsByYear W32042222252023 @default.
• W3204222225 crossrefType "journal-article" @default.
• W3204222225 hasAuthorship W3204222225A5056454004 @default.
• W3204222225 hasAuthorship W3204222225A5082086115 @default.
• W3204222225 hasAuthorship W3204222225A5084072550 @default.
• W3204222225 hasBestOaLocation W32042222251 @default.
• W3204222225 hasConcept C121608353 @default.
• W3204222225 hasConcept C126322002 @default.
• W3204222225 hasConcept C143998085 @default.
• W3204222225 hasConcept C207103383 @default.
• W3204222225 hasConcept C2779306644 @default.
• W3204222225 hasConcept C2779473830 @default.
• W3204222225 hasConcept C2780192828 @default.
• W3204222225 hasConcept C2780323712 @default.
• W3204222225 hasConcept C3020774429 @default.
• W3204222225 hasConcept C44249647 @default.
• W3204222225 hasConcept C55493867 @default.
• W3204222225 hasConcept C71924100 @default.
• W3204222225 hasConcept C86803240 @default.
• W3204222225 hasConcept C95190672 @default.
• W3204222225 hasConceptScore W3204222225C121608353 @default.
• W3204222225 hasConceptScore W3204222225C126322002 @default.
• W3204222225 hasConceptScore W3204222225C143998085 @default.
• W3204222225 hasConceptScore W3204222225C207103383 @default.
• W3204222225 hasConceptScore W3204222225C2779306644 @default.
• W3204222225 hasConceptScore W3204222225C2779473830 @default.
• W3204222225 hasConceptScore W3204222225C2780192828 @default.
• W3204222225 hasConceptScore W3204222225C2780323712 @default.
• W3204222225 hasConceptScore W3204222225C3020774429 @default.
• W3204222225 hasConceptScore W3204222225C44249647 @default.

• next