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- W3204223822 endingPage "5992" @default.
- W3204223822 startingPage "5992" @default.
- W3204223822 abstract "Glioblastoma Multiforme (GBM) is a brain tumor with a poor prognosis and low survival rates. GBM is diagnosed at an advanced stage, so little information is available on the early stage of the disease and few improvements have been made for earlier diagnosis. Longitudinal murine models are a promising platform for biomarker discovery as they allow access to the early stages of the disease. Nevertheless, their use in proteomics has been limited owing to the low sample amount that can be collected at each longitudinal time point. Here we used optimized microproteomics workflows to investigate longitudinal changes in the protein profile of serum, serum small extracellular vesicles (sEVs), and cerebrospinal fluid (CSF) in a GBM murine model. Baseline, pre-symptomatic, and symptomatic tumor stages were determined using non-invasive motor tests. Forty-four proteins displayed significant differences in signal intensities during GBM progression. Dysregulated proteins are involved in cell motility, cell growth, and angiogenesis. Most of the dysregulated proteins already exhibited a difference from baseline at the pre-symptomatic stage of the disease, suggesting that early effects of GBM might be detectable before symptom onset." @default.
- W3204223822 created "2021-10-11" @default.
- W3204223822 creator A5033661944 @default.
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- W3204223822 creator A5089765353 @default.
- W3204223822 date "2021-10-02" @default.
- W3204223822 modified "2023-10-01" @default.
- W3204223822 title "Longitudinal Bottom-Up Proteomics of Serum, Serum Extracellular Vesicles, and Cerebrospinal Fluid Reveals Candidate Biomarkers for Early Detection of Glioblastoma in a Murine Model" @default.
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- W3204223822 doi "https://doi.org/10.3390/molecules26195992" @default.
- W3204223822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8512455" @default.
- W3204223822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34641541" @default.
- W3204223822 hasPublicationYear "2021" @default.
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