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• W3204224734 abstract "To assess by transcranial magnetic stimulation (TMS) the excitability of various cortical circuits in akinetic-rigid and tremor-dominant subtypes of Parkinson's disease (PD). The study included 92 patients with PD according to UK Brain Bank criteria, with akinetic-rigid ( n = 64) or tremor-dominant ( n = 28) subtype. Cortical excitability study, including resting and active motor thresholds (rMT and aMT), input—output curve of motor evoked potentials, contralateral and ipsilateral silent periods (cSP and iSP), short and long-interval intracortical inhibition (SICI and LICI), and intracortical facilitation (ICF) were measured. The results obtained were compared to a control group of 30 age- and sex-matched healthy subjects. The patients in the tremor group had significantly lower rMT and aMT compared to controls and akinetic-rigid patients and significantly shorter iSP duration compared to akinetic-rigid patients, while iSP latency tended to be longer in akinetic-rigid patients compared to controls. There were no significant differences between the two PD subgroups regarding other cortical excitability parameters, including paired-pulse TMS parameters. Only subtle differences of cortical excitability were found between patients with akinetic-rigid vs. tremor-dominant subtype of PD. The clinical heterogeneity of PD patients probably has an impact on cortical excitability measures, far beyond the akinetic-rigid versus tremor-dominant profile." @default.
• W3204224734 created "2021-10-11" @default.
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• W3204224734 date "2021-10-01" @default.
• W3204224734 modified "2023-10-01" @default.
• W3204224734 title "Are there differences in cortical excitability between akinetic-rigid and tremor-dominant subtypes of Parkinson's disease?" @default.
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• W3204224734 doi "https://doi.org/10.1016/j.neucli.2021.08.002" @default.
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