FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204226501> ?p ?o ?g. }

• W3204226501 abstract "Voltage-gated Kv1.3 potassium channels are key regulators of T lymphocyte activation, proliferation and cytokine production, by providing the necessary membrane hyper-polarization for calcium influx following immune stimulation. It is noteworthy that an accumulating body of in vivo and in vitro evidence links these channels to multiple sclerosis pathophysiology. Here we studied the electrophysiological properties and the transcriptional and translational expression of T lymphocyte Kv1.3 channels in multiple sclerosis, by combining patch clamp recordings, reverse transcription polymerase chain reaction and flow cytometry on freshly isolated peripheral blood T lymphocytes from two patient cohorts with multiple sclerosis, as well as from healthy and disease controls. Our data demonstrate that T lymphocytes in MS, manifest a significant up-regulation of Kv1.3 mRNA, Kv1.3 membrane protein and Kv1.3 current density and therefore of functional membrane channel protein, compared to control groups (p < 0.001). Interestingly, patient sub-grouping shows that Kv1.3 channel density is significantly higher in secondary progressive, compared to relapsing-remitting multiple sclerosis (p < 0.001). Taking into account the tight connection between Kv1.3 channel activity and calcium-dependent processes, our data predict and could partly explain the reported alterations of T lymphocyte function in multiple sclerosis, while they highlight Kv1.3 channels as potential therapeutic targets and peripheral biomarkers for the disease." @default.
• W3204226501 created "2021-10-11" @default.
• W3204226501 creator A5007341235 @default.
• W3204226501 creator A5014582592 @default.
• W3204226501 creator A5031869713 @default.
• W3204226501 creator A5043567383 @default.
• W3204226501 creator A5060070463 @default.
• W3204226501 creator A5073217367 @default.
• W3204226501 creator A5079484361 @default.
• W3204226501 creator A5086003240 @default.
• W3204226501 creator A5090815394 @default.
• W3204226501 creator A5053779230 @default.
• W3204226501 date "2021-09-23" @default.
• W3204226501 modified "2023-09-30" @default.
• W3204226501 title "Kv1.3 Channel Up-Regulation in Peripheral Blood T Lymphocytes of Patients With Multiple Sclerosis" @default.
• W3204226501 cites W1494747905 @default.
• W3204226501 cites W1973670013 @default.
• W3204226501 cites W1982991759 @default.
• W3204226501 cites W1984445978 @default.
• W3204226501 cites W2011781890 @default.
• W3204226501 cites W2012801243 @default.
• W3204226501 cites W2019310318 @default.
• W3204226501 cites W2022760884 @default.
• W3204226501 cites W2030790147 @default.
• W3204226501 cites W2032786593 @default.
• W3204226501 cites W2036704251 @default.
• W3204226501 cites W2056769769 @default.
• W3204226501 cites W2066603202 @default.
• W3204226501 cites W2069078301 @default.
• W3204226501 cites W2070363719 @default.
• W3204226501 cites W2082382361 @default.
• W3204226501 cites W2082883776 @default.
• W3204226501 cites W2086256855 @default.
• W3204226501 cites W2088761023 @default.
• W3204226501 cites W2096618637 @default.
• W3204226501 cites W2099560139 @default.
• W3204226501 cites W2105206040 @default.
• W3204226501 cites W2109495864 @default.
• W3204226501 cites W2121569266 @default.
• W3204226501 cites W2123879187 @default.
• W3204226501 cites W2125337252 @default.
• W3204226501 cites W2128957241 @default.
• W3204226501 cites W2137277521 @default.
• W3204226501 cites W2138274803 @default.
• W3204226501 cites W2142577589 @default.
• W3204226501 cites W2144151756 @default.
• W3204226501 cites W2167355269 @default.
• W3204226501 cites W2171397519 @default.
• W3204226501 cites W2203188308 @default.
• W3204226501 cites W2352236166 @default.
• W3204226501 cites W2527382084 @default.
• W3204226501 cites W2594633730 @default.
• W3204226501 cites W2777074421 @default.
• W3204226501 cites W2791238032 @default.
• W3204226501 cites W2980955515 @default.
• W3204226501 cites W3006596391 @default.
• W3204226501 cites W4251348922 @default.
• W3204226501 cites W87082738 @default.
• W3204226501 doi "https://doi.org/10.3389/fphar.2021.714841" @default.
• W3204226501 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8495199" @default.
• W3204226501 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34630091" @default.
• W3204226501 hasPublicationYear "2021" @default.
• W3204226501 type Work @default.
• W3204226501 sameAs 3204226501 @default.
• W3204226501 citedByCount "1" @default.
• W3204226501 countsByYear W32042265012023 @default.
• W3204226501 crossrefType "journal-article" @default.
• W3204226501 hasAuthorship W3204226501A5007341235 @default.
• W3204226501 hasAuthorship W3204226501A5014582592 @default.
• W3204226501 hasAuthorship W3204226501A5031869713 @default.
• W3204226501 hasAuthorship W3204226501A5043567383 @default.
• W3204226501 hasAuthorship W3204226501A5053779230 @default.
• W3204226501 hasAuthorship W3204226501A5060070463 @default.
• W3204226501 hasAuthorship W3204226501A5073217367 @default.
• W3204226501 hasAuthorship W3204226501A5079484361 @default.
• W3204226501 hasAuthorship W3204226501A5086003240 @default.
• W3204226501 hasAuthorship W3204226501A5090815394 @default.
• W3204226501 hasBestOaLocation W32042265011 @default.
• W3204226501 hasConcept C126322002 @default.
• W3204226501 hasConcept C150903083 @default.
• W3204226501 hasConcept C185592680 @default.
• W3204226501 hasConcept C203014093 @default.
• W3204226501 hasConcept C207001950 @default.
• W3204226501 hasConcept C24998067 @default.
• W3204226501 hasConcept C2777761686 @default.
• W3204226501 hasConcept C2780640218 @default.
• W3204226501 hasConcept C553184892 @default.
• W3204226501 hasConcept C71924100 @default.
• W3204226501 hasConcept C83743174 @default.
• W3204226501 hasConcept C86803240 @default.
• W3204226501 hasConcept C8891405 @default.
• W3204226501 hasConcept C95444343 @default.
• W3204226501 hasConceptScore W3204226501C126322002 @default.
• W3204226501 hasConceptScore W3204226501C150903083 @default.
• W3204226501 hasConceptScore W3204226501C185592680 @default.
• W3204226501 hasConceptScore W3204226501C203014093 @default.
• W3204226501 hasConceptScore W3204226501C207001950 @default.
• W3204226501 hasConceptScore W3204226501C24998067 @default.
• W3204226501 hasConceptScore W3204226501C2777761686 @default.
• W3204226501 hasConceptScore W3204226501C2780640218 @default.

• next