Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204229167> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3204229167 endingPage "9125" @default.
- W3204229167 startingPage "9125" @default.
- W3204229167 abstract "A concise synthesis of the proposed structure of aaptoline B, a pyrroloquinoline derived from a marine sponge, was accomplished. A key feature of this synthesis is the versatile transition metal-catalyzed cycloisomerization of N-propargylaniline to construct a quinoline skeleton. However, the spectral data of the synthesized aaptoline B did not agree with those of previous studies. The structure of the synthesized aaptoline B was confirmed using a combined 2D NMR analysis. Furthermore, we assessed the possible neuroprotective potential of aaptoline B using the C. elegans model system. In this study, aaptoline B significantly improved the viability and the morphology of dopaminergic neurons of nematodes under MPP+ exposure conditions. We also found that MPP+-induced motor deficits in nematodes were efficiently restored by aaptoline B treatment. Our findings demonstrate the neuroprotective effects of aaptoline B against MPP+-induced dopaminergic neuronal damage. Further studies are underway to explain its pharmacological mechanism." @default.
- W3204229167 created "2021-10-11" @default.
- W3204229167 creator A5010106483 @default.
- W3204229167 creator A5015018518 @default.
- W3204229167 creator A5019429913 @default.
- W3204229167 creator A5024208790 @default.
- W3204229167 date "2021-09-30" @default.
- W3204229167 modified "2023-09-26" @default.
- W3204229167 title "Synthesis of Proposed Structure of Aaptoline B via Transition Metal-Catalyzed Cycloisomerization and Evaluation of Its Neuroprotective Properties in C. Elegans" @default.
- W3204229167 cites W1989341278 @default.
- W3204229167 cites W2023018514 @default.
- W3204229167 cites W2053180614 @default.
- W3204229167 cites W2070863923 @default.
- W3204229167 cites W2113600008 @default.
- W3204229167 cites W2123522091 @default.
- W3204229167 cites W2332151162 @default.
- W3204229167 cites W2464977649 @default.
- W3204229167 cites W2605478093 @default.
- W3204229167 cites W2892322286 @default.
- W3204229167 cites W2977973706 @default.
- W3204229167 cites W2994733457 @default.
- W3204229167 cites W3008040930 @default.
- W3204229167 cites W3046598720 @default.
- W3204229167 cites W3083234820 @default.
- W3204229167 doi "https://doi.org/10.3390/app11199125" @default.
- W3204229167 hasPublicationYear "2021" @default.
- W3204229167 type Work @default.
- W3204229167 sameAs 3204229167 @default.
- W3204229167 citedByCount "2" @default.
- W3204229167 countsByYear W32042291672022 @default.
- W3204229167 countsByYear W32042291672023 @default.
- W3204229167 crossrefType "journal-article" @default.
- W3204229167 hasAuthorship W3204229167A5010106483 @default.
- W3204229167 hasAuthorship W3204229167A5015018518 @default.
- W3204229167 hasAuthorship W3204229167A5019429913 @default.
- W3204229167 hasAuthorship W3204229167A5024208790 @default.
- W3204229167 hasBestOaLocation W32042291671 @default.
- W3204229167 hasConcept C137183658 @default.
- W3204229167 hasConcept C161790260 @default.
- W3204229167 hasConcept C169760540 @default.
- W3204229167 hasConcept C185592680 @default.
- W3204229167 hasConcept C25498285 @default.
- W3204229167 hasConcept C2776788722 @default.
- W3204229167 hasConcept C513476851 @default.
- W3204229167 hasConcept C55493867 @default.
- W3204229167 hasConcept C71240020 @default.
- W3204229167 hasConcept C86803240 @default.
- W3204229167 hasConceptScore W3204229167C137183658 @default.
- W3204229167 hasConceptScore W3204229167C161790260 @default.
- W3204229167 hasConceptScore W3204229167C169760540 @default.
- W3204229167 hasConceptScore W3204229167C185592680 @default.
- W3204229167 hasConceptScore W3204229167C25498285 @default.
- W3204229167 hasConceptScore W3204229167C2776788722 @default.
- W3204229167 hasConceptScore W3204229167C513476851 @default.
- W3204229167 hasConceptScore W3204229167C55493867 @default.
- W3204229167 hasConceptScore W3204229167C71240020 @default.
- W3204229167 hasConceptScore W3204229167C86803240 @default.
- W3204229167 hasFunder F4320322120 @default.
- W3204229167 hasIssue "19" @default.
- W3204229167 hasLocation W32042291671 @default.
- W3204229167 hasOpenAccess W3204229167 @default.
- W3204229167 hasPrimaryLocation W32042291671 @default.
- W3204229167 hasRelatedWork W2016213053 @default.
- W3204229167 hasRelatedWork W2088699892 @default.
- W3204229167 hasRelatedWork W2133643242 @default.
- W3204229167 hasRelatedWork W2168941505 @default.
- W3204229167 hasRelatedWork W2169905941 @default.
- W3204229167 hasRelatedWork W2531396172 @default.
- W3204229167 hasRelatedWork W3035986152 @default.
- W3204229167 hasRelatedWork W3119178414 @default.
- W3204229167 hasRelatedWork W3207395543 @default.
- W3204229167 hasRelatedWork W3215019648 @default.
- W3204229167 hasVolume "11" @default.
- W3204229167 isParatext "false" @default.
- W3204229167 isRetracted "false" @default.
- W3204229167 magId "3204229167" @default.
- W3204229167 workType "article" @default.