FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204232661> ?p ?o ?g. }

• W3204232661 endingPage "2699" @default.
• W3204232661 startingPage "2692" @default.
• W3204232661 abstract "The entomopathogenic bacterium Xenorhabdus bovienii exists in a mutualistic relationship with nematodes of the genus Steinernema. Free-living infective juveniles of Steinernema prey on insect larvae and regurgitate X. bovienii within the hemocoel of a host larva. X. bovienii subsequently produces a complex array of specialized metabolites and effector proteins that kill the insect and regulate various aspects of the trilateral symbiosis. While Xenorhabdus species are rich producers of secondary metabolites, many of their biosynthetic gene clusters remain uncharacterized. Here, we describe a nonribosomal peptide synthetase (NRPS) identified through comparative genomics analysis that is widely conserved in Xenorhabdus species. Heterologous expression of this NRPS gene from X. bovienii in E. coli led to the discovery of a family of lipo-tripeptides that chromatographically appear as pairs, containing either a C-terminal carboxylic acid or carboxamide. Coexpression of the NRPS with the leupeptin protease inhibitor pathway enhanced production, facilitating isolation and characterization efforts. The new lipo-tripeptides were also detected in wild-type X. bovienii cultures. These metabolites, termed bovienimides, share an uncommon C-terminal d-citrulline residue. The NRPS lacked a dedicated chain termination domain, resulting in product diversification and release from the assembly line through reactions with ammonia, water, or exogenous alcohols." @default.
• W3204232661 created "2021-10-11" @default.
• W3204232661 creator A5003015031 @default.
• W3204232661 creator A5003765180 @default.
• W3204232661 creator A5018028906 @default.
• W3204232661 creator A5066191398 @default.
• W3204232661 creator A5071994816 @default.
• W3204232661 date "2021-09-28" @default.
• W3204232661 modified "2023-09-26" @default.
• W3204232661 title "A Conserved Nonribosomal Peptide Synthetase in <i>Xenorhabdus bovienii</i> Produces Citrulline-Functionalized Lipopeptides" @default.
• W3204232661 cites W1934400729 @default.
• W3204232661 cites W1965582988 @default.
• W3204232661 cites W1966493554 @default.
• W3204232661 cites W1988354719 @default.
• W3204232661 cites W1992118967 @default.
• W3204232661 cites W2003845354 @default.
• W3204232661 cites W2006599461 @default.
• W3204232661 cites W2036251618 @default.
• W3204232661 cites W2037205941 @default.
• W3204232661 cites W2038750453 @default.
• W3204232661 cites W2052173805 @default.
• W3204232661 cites W2053600742 @default.
• W3204232661 cites W2059148224 @default.
• W3204232661 cites W2069429664 @default.
• W3204232661 cites W2070305972 @default.
• W3204232661 cites W2076915648 @default.
• W3204232661 cites W2077781738 @default.
• W3204232661 cites W2080895748 @default.
• W3204232661 cites W2088953549 @default.
• W3204232661 cites W2090288316 @default.
• W3204232661 cites W2100693791 @default.
• W3204232661 cites W2104223886 @default.
• W3204232661 cites W2105708163 @default.
• W3204232661 cites W2105808479 @default.
• W3204232661 cites W2110320743 @default.
• W3204232661 cites W2114839447 @default.
• W3204232661 cites W2116440537 @default.
• W3204232661 cites W2136326394 @default.
• W3204232661 cites W2152439246 @default.
• W3204232661 cites W2162011385 @default.
• W3204232661 cites W2462908446 @default.
• W3204232661 cites W2508980186 @default.
• W3204232661 cites W2588708567 @default.
• W3204232661 cites W2594318335 @default.
• W3204232661 cites W2604849957 @default.
• W3204232661 cites W2605875623 @default.
• W3204232661 cites W2620412605 @default.
• W3204232661 cites W2789572960 @default.
• W3204232661 cites W2889198792 @default.
• W3204232661 cites W2940690307 @default.
• W3204232661 cites W2942829220 @default.
• W3204232661 cites W2981519702 @default.
• W3204232661 cites W2992507039 @default.
• W3204232661 cites W3038960277 @default.
• W3204232661 cites W3092812134 @default.
• W3204232661 doi "https://doi.org/10.1021/acs.jnatprod.1c00573" @default.
• W3204232661 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34581573" @default.
• W3204232661 hasPublicationYear "2021" @default.
• W3204232661 type Work @default.
• W3204232661 sameAs 3204232661 @default.
• W3204232661 citedByCount "4" @default.
• W3204232661 countsByYear W32042326612022 @default.
• W3204232661 crossrefType "journal-article" @default.
• W3204232661 hasAuthorship W3204232661A5003015031 @default.
• W3204232661 hasAuthorship W3204232661A5003765180 @default.
• W3204232661 hasAuthorship W3204232661A5018028906 @default.
• W3204232661 hasAuthorship W3204232661A5066191398 @default.
• W3204232661 hasAuthorship W3204232661A5071994816 @default.
• W3204232661 hasBestOaLocation W32042326612 @default.
• W3204232661 hasConcept C104317684 @default.
• W3204232661 hasConcept C108305142 @default.
• W3204232661 hasConcept C167392928 @default.
• W3204232661 hasConcept C2776213388 @default.
• W3204232661 hasConcept C2777379556 @default.
• W3204232661 hasConcept C2779281246 @default.
• W3204232661 hasConcept C40767141 @default.
• W3204232661 hasConcept C553450214 @default.
• W3204232661 hasConcept C55493867 @default.
• W3204232661 hasConcept C86803240 @default.
• W3204232661 hasConceptScore W3204232661C104317684 @default.
• W3204232661 hasConceptScore W3204232661C108305142 @default.
• W3204232661 hasConceptScore W3204232661C167392928 @default.
• W3204232661 hasConceptScore W3204232661C2776213388 @default.
• W3204232661 hasConceptScore W3204232661C2777379556 @default.
• W3204232661 hasConceptScore W3204232661C2779281246 @default.
• W3204232661 hasConceptScore W3204232661C40767141 @default.
• W3204232661 hasConceptScore W3204232661C553450214 @default.
• W3204232661 hasConceptScore W3204232661C55493867 @default.
• W3204232661 hasConceptScore W3204232661C86803240 @default.
• W3204232661 hasFunder F4320337354 @default.
• W3204232661 hasIssue "10" @default.
• W3204232661 hasLocation W32042326611 @default.
• W3204232661 hasLocation W32042326612 @default.
• W3204232661 hasLocation W32042326613 @default.
• W3204232661 hasOpenAccess W3204232661 @default.
• W3204232661 hasPrimaryLocation W32042326611 @default.
• W3204232661 hasRelatedWork W2011385454 @default.
• W3204232661 hasRelatedWork W2041254003 @default.

• next