Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204235500> ?p ?o ?g. }
- W3204235500 abstract "Multiple myeloma (MM) is an incurable plasma cell malignancy in the bone marrow characterized by chromosome instability (CIN), which contributes to the acquisition of heterogeneity, along with MM progression, drug resistance, and relapse. In this study, we elucidated that the expression of BUB1B increased strikingly in MM patients and was closely correlated with poor outcomes. Overexpression of BUB1B facilitated cellular proliferation and induced drug resistance in vitro and in vivo, while genetic targeting BUB1B abrogated this effect. Mechanistic studies unveiled that enforced expression of BUB1B evoked CIN resulting in MM poor outcomes mainly through phosphorylating CEP170. Interestingly, we discovered the existence of circBUB1B_544aa containing the kinase catalytic center of BUB1B, which was translated by a circular RNA of BUB1B. The circBUB1B_544aa elevated in MM peripheral blood samples was closely associated with MM poor outcomes and played a synergistic effect with BUB1B on evoking CIN. In addition, MM cells could secrete circBUB1B_544aa and interfere the MM microenvironmental cells in the same manner as BUB1B full-length protein. Intriguingly, BUB1B siRNA, targeting the kinase catalytic center of both BUB1B and circBUB1B_544aa, significantly inhibited MM malignancy in vitro and in vivo. Collectively, BUB1B and circBUB1B_544aa are promising prognostic and therapeutic targets of MM." @default.
- W3204235500 created "2021-10-11" @default.
- W3204235500 creator A5001026091 @default.
- W3204235500 creator A5010226687 @default.
- W3204235500 creator A5029043916 @default.
- W3204235500 creator A5029900439 @default.
- W3204235500 creator A5032161199 @default.
- W3204235500 creator A5045477256 @default.
- W3204235500 creator A5062799133 @default.
- W3204235500 creator A5071723551 @default.
- W3204235500 creator A5072858878 @default.
- W3204235500 creator A5086052497 @default.
- W3204235500 creator A5088536927 @default.
- W3204235500 creator A5091146388 @default.
- W3204235500 date "2021-10-07" @default.
- W3204235500 modified "2023-10-15" @default.
- W3204235500 title "BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability" @default.
- W3204235500 cites W1535017397 @default.
- W3204235500 cites W1770991729 @default.
- W3204235500 cites W1846631206 @default.
- W3204235500 cites W1963713396 @default.
- W3204235500 cites W1965730026 @default.
- W3204235500 cites W1967406345 @default.
- W3204235500 cites W1967791012 @default.
- W3204235500 cites W1977517445 @default.
- W3204235500 cites W1999560226 @default.
- W3204235500 cites W2012339102 @default.
- W3204235500 cites W2014501499 @default.
- W3204235500 cites W2045021130 @default.
- W3204235500 cites W2053014012 @default.
- W3204235500 cites W2072479339 @default.
- W3204235500 cites W2074208201 @default.
- W3204235500 cites W2095369118 @default.
- W3204235500 cites W2107767405 @default.
- W3204235500 cites W2108624984 @default.
- W3204235500 cites W2109393499 @default.
- W3204235500 cites W2114460232 @default.
- W3204235500 cites W2119462367 @default.
- W3204235500 cites W2128549339 @default.
- W3204235500 cites W2138497413 @default.
- W3204235500 cites W2142739728 @default.
- W3204235500 cites W2149055925 @default.
- W3204235500 cites W2152603947 @default.
- W3204235500 cites W2155165473 @default.
- W3204235500 cites W2157833423 @default.
- W3204235500 cites W2164723344 @default.
- W3204235500 cites W2266356262 @default.
- W3204235500 cites W2273305869 @default.
- W3204235500 cites W2318224129 @default.
- W3204235500 cites W2592988313 @default.
- W3204235500 cites W2596994218 @default.
- W3204235500 cites W2600581473 @default.
- W3204235500 cites W2601436215 @default.
- W3204235500 cites W2606110647 @default.
- W3204235500 cites W2606970705 @default.
- W3204235500 cites W2736218411 @default.
- W3204235500 cites W2750771238 @default.
- W3204235500 cites W2752880228 @default.
- W3204235500 cites W2762996338 @default.
- W3204235500 cites W2782188584 @default.
- W3204235500 cites W2783029521 @default.
- W3204235500 cites W2793975106 @default.
- W3204235500 cites W2799757935 @default.
- W3204235500 cites W2803911979 @default.
- W3204235500 cites W2811482166 @default.
- W3204235500 cites W2898504901 @default.
- W3204235500 cites W2912017471 @default.
- W3204235500 cites W2912362240 @default.
- W3204235500 cites W2914789330 @default.
- W3204235500 cites W2922400209 @default.
- W3204235500 cites W2945274796 @default.
- W3204235500 cites W2952016992 @default.
- W3204235500 cites W2964897087 @default.
- W3204235500 cites W2974077270 @default.
- W3204235500 cites W2981875119 @default.
- W3204235500 cites W2982361973 @default.
- W3204235500 cites W2990601320 @default.
- W3204235500 cites W3006211741 @default.
- W3204235500 cites W3011917394 @default.
- W3204235500 cites W3106591850 @default.
- W3204235500 doi "https://doi.org/10.1038/s41392-021-00746-6" @default.
- W3204235500 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8497505" @default.
- W3204235500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34620840" @default.
- W3204235500 hasPublicationYear "2021" @default.
- W3204235500 type Work @default.
- W3204235500 sameAs 3204235500 @default.
- W3204235500 citedByCount "20" @default.
- W3204235500 countsByYear W32042355002022 @default.
- W3204235500 countsByYear W32042355002023 @default.
- W3204235500 crossrefType "journal-article" @default.
- W3204235500 hasAuthorship W3204235500A5001026091 @default.
- W3204235500 hasAuthorship W3204235500A5010226687 @default.
- W3204235500 hasAuthorship W3204235500A5029043916 @default.
- W3204235500 hasAuthorship W3204235500A5029900439 @default.
- W3204235500 hasAuthorship W3204235500A5032161199 @default.
- W3204235500 hasAuthorship W3204235500A5045477256 @default.
- W3204235500 hasAuthorship W3204235500A5062799133 @default.
- W3204235500 hasAuthorship W3204235500A5071723551 @default.
- W3204235500 hasAuthorship W3204235500A5072858878 @default.
- W3204235500 hasAuthorship W3204235500A5086052497 @default.