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• W3204236198 abstract "Abstract The L-type calcium current (I CaL ) plays a critical role in cardiac electrophysiology, and models of I CaL are vital tools to predict arrhythmogenicity of drugs and mutations. Five decades of measuring and modelling I CaL have resulted in several competing theories (encoded in mathematical equations). However, the introduction of new models has not typically been accompanied by a data-driven critical comparison with previous work, so that it is unclear which model is best suited for any particular application. In this review, we describe and compare 73 published mammalian I CaL models, and use simulated experiments to show that there is a large variability in their predictions, which is not substantially diminished when grouping by species or other categories. We provide model code for 60 models, list major data sources, and discuss experimental and modelling work that will be required to reduce this huge list of competing theories and ultimately develop a community consensus model of I CaL ." @default.
• W3204236198 created "2021-10-11" @default.
• W3204236198 creator A5003271159 @default.
• W3204236198 creator A5021215644 @default.
• W3204236198 creator A5057406438 @default.
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• W3204236198 creator A5085961856 @default.
• W3204236198 creator A5090359959 @default.
• W3204236198 creator A5090615661 @default.
• W3204236198 date "2021-10-05" @default.
• W3204236198 modified "2023-10-16" @default.
• W3204236198 title "Models of the cardiac L-type calcium current: a quantitative review" @default.
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