FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204237160> ?p ?o ?g. }

• W3204237160 abstract "SUMMARY BRAF is frequently mutated in human cancer and the RASopathy syndromes, with RASopathy mutations often observed in the cysteine-rich domain (CRD). Although the CRD participates in phosphatidylserine (PS) binding, the RAS-RAF interaction, and RAF autoinhibition, the impact of these activities on RAF function in normal and disease states is not well-characterized. Here, we analyze a panel of CRD mutations and show that they increase BRAF activity by relieving autoinhibition and/or enhancing PS binding, with relief of autoinhibition being the major factor determining mutation severity in zebrafish models. Further, we show that CRD-mediated autoinhibition is essential for preventing the constitutive plasma membrane localization of BRAF and increased RAS-dependent and RAS-independent function. Comparison of the BRAF- and CRAF-CRDs also indicates that the BRAF-CRD is a stronger mediator of autoinhibition and PS binding, and given the increased catalytic activity of BRAF, our studies reveal a more critical role for CRD-mediated autoinhibition in BRAF regulation." @default.
• W3204237160 created "2021-10-11" @default.
• W3204237160 creator A5000884417 @default.
• W3204237160 creator A5010061597 @default.
• W3204237160 creator A5038827194 @default.
• W3204237160 creator A5049188516 @default.
• W3204237160 creator A5057963999 @default.
• W3204237160 creator A5061515984 @default.
• W3204237160 creator A5063601462 @default.
• W3204237160 creator A5070024846 @default.
• W3204237160 creator A5072178562 @default.
• W3204237160 date "2021-10-02" @default.
• W3204237160 modified "2023-10-02" @default.
• W3204237160 title "RASopathy Mutations Provide Functional Insight into the BRAF Cysteine-rich Domain and Demonstrate the Importance of Autoinhibition in BRAF Regulation" @default.
• W3204237160 cites W1489297798 @default.
• W3204237160 cites W1593810032 @default.
• W3204237160 cites W169361905 @default.
• W3204237160 cites W1965084076 @default.
• W3204237160 cites W1970857342 @default.
• W3204237160 cites W1972449266 @default.
• W3204237160 cites W1979016878 @default.
• W3204237160 cites W1991760443 @default.
• W3204237160 cites W1995624041 @default.
• W3204237160 cites W1996872108 @default.
• W3204237160 cites W1996962669 @default.
• W3204237160 cites W2001520967 @default.
• W3204237160 cites W2003349514 @default.
• W3204237160 cites W2007537308 @default.
• W3204237160 cites W2033185023 @default.
• W3204237160 cites W2043617365 @default.
• W3204237160 cites W2054292493 @default.
• W3204237160 cites W2054946171 @default.
• W3204237160 cites W2056750804 @default.
• W3204237160 cites W2066489411 @default.
• W3204237160 cites W2070204715 @default.
• W3204237160 cites W2074571373 @default.
• W3204237160 cites W2080549930 @default.
• W3204237160 cites W2086386747 @default.
• W3204237160 cites W2088064651 @default.
• W3204237160 cites W2088293068 @default.
• W3204237160 cites W2099230193 @default.
• W3204237160 cites W2105467845 @default.
• W3204237160 cites W2105726821 @default.
• W3204237160 cites W2117669008 @default.
• W3204237160 cites W2122431703 @default.
• W3204237160 cites W2122840807 @default.
• W3204237160 cites W2140998787 @default.
• W3204237160 cites W2167197258 @default.
• W3204237160 cites W2171529739 @default.
• W3204237160 cites W2399229449 @default.
• W3204237160 cites W2462226918 @default.
• W3204237160 cites W2565755607 @default.
• W3204237160 cites W2600452872 @default.
• W3204237160 cites W2785254688 @default.
• W3204237160 cites W2807050062 @default.
• W3204237160 cites W2903703987 @default.
• W3204237160 cites W2913027519 @default.
• W3204237160 cites W2978479061 @default.
• W3204237160 cites W2980302585 @default.
• W3204237160 cites W3007721372 @default.
• W3204237160 cites W3025847794 @default.
• W3204237160 cites W3033954010 @default.
• W3204237160 cites W3038019155 @default.
• W3204237160 cites W3131852822 @default.
• W3204237160 cites W3143653395 @default.
• W3204237160 cites W4213351467 @default.
• W3204237160 cites W4230421038 @default.
• W3204237160 doi "https://doi.org/10.1101/2021.10.01.462773" @default.
• W3204237160 hasPublicationYear "2021" @default.
• W3204237160 type Work @default.
• W3204237160 sameAs 3204237160 @default.
• W3204237160 citedByCount "1" @default.
• W3204237160 countsByYear W32042371602023 @default.
• W3204237160 crossrefType "posted-content" @default.
• W3204237160 hasAuthorship W3204237160A5000884417 @default.
• W3204237160 hasAuthorship W3204237160A5010061597 @default.
• W3204237160 hasAuthorship W3204237160A5038827194 @default.
• W3204237160 hasAuthorship W3204237160A5049188516 @default.
• W3204237160 hasAuthorship W3204237160A5057963999 @default.
• W3204237160 hasAuthorship W3204237160A5061515984 @default.
• W3204237160 hasAuthorship W3204237160A5063601462 @default.
• W3204237160 hasAuthorship W3204237160A5070024846 @default.
• W3204237160 hasAuthorship W3204237160A5072178562 @default.
• W3204237160 hasBestOaLocation W32042371601 @default.
• W3204237160 hasConcept C104317684 @default.
• W3204237160 hasConcept C14036430 @default.
• W3204237160 hasConcept C181199279 @default.
• W3204237160 hasConcept C185592680 @default.
• W3204237160 hasConcept C2776878037 @default.
• W3204237160 hasConcept C2779201268 @default.
• W3204237160 hasConcept C501734568 @default.
• W3204237160 hasConcept C502942594 @default.
• W3204237160 hasConcept C55493867 @default.
• W3204237160 hasConcept C70721500 @default.
• W3204237160 hasConcept C86803240 @default.
• W3204237160 hasConcept C95444343 @default.
• W3204237160 hasConceptScore W3204237160C104317684 @default.
• W3204237160 hasConceptScore W3204237160C14036430 @default.
• W3204237160 hasConceptScore W3204237160C181199279 @default.
• W3204237160 hasConceptScore W3204237160C185592680 @default.

• next