FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204238993> ?p ?o ?g. }

• W3204238993 endingPage "255" @default.
• W3204238993 startingPage "245" @default.
• W3204238993 abstract "Orthostatic symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) may be caused by an abnormal reduction in cerebral blood flow. An abnormal cerebral blood flow reduction was shown in previous studies, without information on the recovery pace of cerebral blood flow. This study examined the prevalence and risk factors for delayed recovery of cerebral blood flow in ME/CFS patients.60 ME/CFS adults were studied: 30 patients had a normal heart rate and blood pressure response during the tilt test, 4 developed delayed orthostatic hypotension, and 26 developed postural orthostatic tachycardia syndrome (POTS) during the tilt. Cerebral blood flow measurements, using extracranial Doppler, were made in the supine position pre-tilt, at end-tilt, and in the supine position at 5 min post-tilt. Also, cardiac index measurements were performed, using suprasternal Doppler imaging, as well as end-tidal PCO2 measurements. The change in cerebral blood flow from supine to end-tilt was expressed as a percent reduction with mean and (SD). Disease severity was scored as mild (approximately 50% reduction in activity), moderate (mostly housebound), or severe (mostly bedbound).End-tilt cerebral blood flow reduction was -29 (6)%, improving to -16 (7)% at post-tilt. No differences in either end-tilt or post-tilt measurements were found when patients with a normal heart rate and blood pressure were compared to those with POTS, or between patients with normocapnia (end-tidal PCO2 ≥ 30 mmHg) versus hypocapnia (end-tidal PCO2 < 30 mmHg) at end-tilt. A significant difference was found in the degree of abnormal cerebral blood flow reduction in the supine post-test in mild, moderate, and severe ME/CFS: mild: cerebral blood flow: -7 (2)%, moderate: -16 (3)%, and severe :-25 (4)% (p all < 0.0001). Cardiac index declined significantly during the tilt test in all 3 severity groups, with no significant differences between the groups. In the supine post-test cardiac index returned to normal in all patients.During tilt testing, extracranial Doppler measurements show that cerebral blood flow is reduced in ME/CFS patients and recovery to normal supine values is incomplete, despite cardiac index returning to pre-tilt values. The delayed recovery of cerebral blood flow was independent of the hemodynamic findings of the tilt test (normal heart rate and blood pressure response, POTS, or delayed orthostatic hypotension), or the presence/absence of hypocapnia, and was only related to clinical ME/CFS severity grading. We observed a significantly slower recovery in cerebral blood flow in the most severely ill ME/CFS patients.The finding that orthostatic stress elicits a post-stress cerebral blood flow reduction and that disease severity greatly influences the cerebral blood flow reduction may have implications on the advice of energy management after a stressor and on the advice of lying down after a stressor in these ME/CFS patients." @default.
• W3204238993 created "2021-10-11" @default.
• W3204238993 creator A5065852957 @default.
• W3204238993 creator A5081227392 @default.
• W3204238993 creator A5087389457 @default.
• W3204238993 date "2021-01-01" @default.
• W3204238993 modified "2023-09-25" @default.
• W3204238993 title "Cerebral blood flow remains reduced after tilt testing in myalgic encephalomyelitis/chronic fatigue syndrome patients" @default.
• W3204238993 cites W1481646674 @default.
• W3204238993 cites W1536892072 @default.
• W3204238993 cites W1827793723 @default.
• W3204238993 cites W1969280818 @default.
• W3204238993 cites W1971295110 @default.
• W3204238993 cites W1979292680 @default.
• W3204238993 cites W1993924238 @default.
• W3204238993 cites W2006125299 @default.
• W3204238993 cites W2009556882 @default.
• W3204238993 cites W2012945682 @default.
• W3204238993 cites W2013933422 @default.
• W3204238993 cites W2016265790 @default.
• W3204238993 cites W2022274370 @default.
• W3204238993 cites W2036930582 @default.
• W3204238993 cites W2050861797 @default.
• W3204238993 cites W2052537294 @default.
• W3204238993 cites W2054627185 @default.
• W3204238993 cites W2065355947 @default.
• W3204238993 cites W2079869342 @default.
• W3204238993 cites W2087691766 @default.
• W3204238993 cites W2098287790 @default.
• W3204238993 cites W2111810521 @default.
• W3204238993 cites W2119384266 @default.
• W3204238993 cites W2121219520 @default.
• W3204238993 cites W2124526983 @default.
• W3204238993 cites W2133700167 @default.
• W3204238993 cites W2140106152 @default.
• W3204238993 cites W2143180730 @default.
• W3204238993 cites W2153430072 @default.
• W3204238993 cites W2155596333 @default.
• W3204238993 cites W2274071791 @default.
• W3204238993 cites W2304612241 @default.
• W3204238993 cites W2592096970 @default.
• W3204238993 cites W2617043069 @default.
• W3204238993 cites W2767596216 @default.
• W3204238993 cites W2793563878 @default.
• W3204238993 cites W2810549826 @default.
• W3204238993 cites W2888455413 @default.
• W3204238993 cites W2893648937 @default.
• W3204238993 cites W2951098723 @default.
• W3204238993 cites W3004729925 @default.
• W3204238993 cites W3005282892 @default.
• W3204238993 cites W3012026219 @default.
• W3204238993 cites W3015148905 @default.
• W3204238993 cites W3034630378 @default.
• W3204238993 cites W3092288996 @default.
• W3204238993 cites W3122609042 @default.
• W3204238993 cites W3144508226 @default.
• W3204238993 cites W3163641299 @default.
• W3204238993 cites W4244638834 @default.
• W3204238993 cites W4249033469 @default.
• W3204238993 doi "https://doi.org/10.1016/j.cnp.2021.09.001" @default.
• W3204238993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8505270" @default.
• W3204238993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34667909" @default.
• W3204238993 hasPublicationYear "2021" @default.
• W3204238993 type Work @default.
• W3204238993 sameAs 3204238993 @default.
• W3204238993 citedByCount "13" @default.
• W3204238993 countsByYear W32042389932021 @default.
• W3204238993 countsByYear W32042389932022 @default.
• W3204238993 countsByYear W32042389932023 @default.
• W3204238993 crossrefType "journal-article" @default.
• W3204238993 hasAuthorship W3204238993A5065852957 @default.
• W3204238993 hasAuthorship W3204238993A5081227392 @default.
• W3204238993 hasAuthorship W3204238993A5087389457 @default.
• W3204238993 hasBestOaLocation W32042389931 @default.
• W3204238993 hasConcept C125567185 @default.
• W3204238993 hasConcept C126322002 @default.
• W3204238993 hasConcept C127413603 @default.
• W3204238993 hasConcept C157767197 @default.
• W3204238993 hasConcept C158846371 @default.
• W3204238993 hasConcept C164705383 @default.
• W3204238993 hasConcept C2777037550 @default.
• W3204238993 hasConcept C2777953023 @default.
• W3204238993 hasConcept C2778553927 @default.
• W3204238993 hasConcept C2778866228 @default.
• W3204238993 hasConcept C2779844322 @default.
• W3204238993 hasConcept C42219234 @default.
• W3204238993 hasConcept C71924100 @default.
• W3204238993 hasConcept C73787029 @default.
• W3204238993 hasConcept C78519656 @default.
• W3204238993 hasConcept C84393581 @default.
• W3204238993 hasConceptScore W3204238993C125567185 @default.
• W3204238993 hasConceptScore W3204238993C126322002 @default.
• W3204238993 hasConceptScore W3204238993C127413603 @default.
• W3204238993 hasConceptScore W3204238993C157767197 @default.
• W3204238993 hasConceptScore W3204238993C158846371 @default.
• W3204238993 hasConceptScore W3204238993C164705383 @default.
• W3204238993 hasConceptScore W3204238993C2777037550 @default.
• W3204238993 hasConceptScore W3204238993C2777953023 @default.

• next