FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204242597> ?p ?o ?g. }

• W3204242597 abstract "To investigate pharmacokinetic and pharmacodynamic differences of zolpidem between males and females and their causes, including CYP3A4 activity. A single oral dose of zolpidem (10 mg) was administered to 15 male and 15 female healthy subjects. Blood samples were collected up to 12 h post-dose to determine plasma zolpidem concentrations. Pharmacokinetic parameters were obtained using non-compartmental analysis. Digit symbol substitution test, choice reaction time, and visual analog scale of sleepiness were used to evaluate pharmacodynamics. We measured CYP3A4 activity using 4β-hydroxycholesterol, an endogenous metabolite. Mean maximum plasma concentration and area under the plasma concentration-time curve were higher for females than for males (9.9% and 32.5%, respectively); other pharmacokinetic parameters showed no significant differences. Pharmacodynamic scores for females showed delayed recovery compared with that for males. CYP3A4 activity was higher in females than in males (p = 0.030). There was no serious adverse event, and adverse event incidence was not different between the sexes. Zolpidem exposure was about 30% higher in females than in males. Delayed pharmacodynamic score recovery in females could be related to higher zolpidem concentrations. Although apparent clearance was lower in females, systemic clearance might not be the cause of the different exposures to zolpidem." @default.
• W3204242597 created "2021-10-11" @default.
• W3204242597 creator A5008017372 @default.
• W3204242597 creator A5016025791 @default.
• W3204242597 creator A5021733307 @default.
• W3204242597 creator A5022675590 @default.
• W3204242597 creator A5030313520 @default.
• W3204242597 creator A5030314659 @default.
• W3204242597 creator A5065271933 @default.
• W3204242597 creator A5074154602 @default.
• W3204242597 creator A5088438048 @default.
• W3204242597 date "2021-09-27" @default.
• W3204242597 modified "2023-10-06" @default.
• W3204242597 title "Effect of CYP3A4 metabolism on sex differences in the pharmacokinetics and pharmacodynamics of zolpidem" @default.
• W3204242597 cites W1484050965 @default.
• W3204242597 cites W1557131785 @default.
• W3204242597 cites W1559218836 @default.
• W3204242597 cites W1593954768 @default.
• W3204242597 cites W1946475820 @default.
• W3204242597 cites W1966106826 @default.
• W3204242597 cites W1971607498 @default.
• W3204242597 cites W1975089669 @default.
• W3204242597 cites W1986218392 @default.
• W3204242597 cites W1999351778 @default.
• W3204242597 cites W2023701920 @default.
• W3204242597 cites W2067477289 @default.
• W3204242597 cites W2068901043 @default.
• W3204242597 cites W2078186665 @default.
• W3204242597 cites W2082861010 @default.
• W3204242597 cites W2108062722 @default.
• W3204242597 cites W2118247434 @default.
• W3204242597 cites W2131375845 @default.
• W3204242597 cites W2133866312 @default.
• W3204242597 cites W2169843481 @default.
• W3204242597 cites W2185216198 @default.
• W3204242597 cites W2531142929 @default.
• W3204242597 cites W2561017480 @default.
• W3204242597 cites W2883645268 @default.
• W3204242597 cites W2888254436 @default.
• W3204242597 cites W2900189453 @default.
• W3204242597 cites W2913866147 @default.
• W3204242597 cites W2932128642 @default.
• W3204242597 cites W2939463022 @default.
• W3204242597 cites W2971584062 @default.
• W3204242597 cites W3037174244 @default.
• W3204242597 cites W4250685861 @default.
• W3204242597 doi "https://doi.org/10.1038/s41598-021-98689-z" @default.
• W3204242597 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8476623" @default.
• W3204242597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34580385" @default.
• W3204242597 hasPublicationYear "2021" @default.
• W3204242597 type Work @default.
• W3204242597 sameAs 3204242597 @default.
• W3204242597 citedByCount "17" @default.
• W3204242597 countsByYear W32042425972022 @default.
• W3204242597 countsByYear W32042425972023 @default.
• W3204242597 crossrefType "journal-article" @default.
• W3204242597 hasAuthorship W3204242597A5008017372 @default.
• W3204242597 hasAuthorship W3204242597A5016025791 @default.
• W3204242597 hasAuthorship W3204242597A5021733307 @default.
• W3204242597 hasAuthorship W3204242597A5022675590 @default.
• W3204242597 hasAuthorship W3204242597A5030313520 @default.
• W3204242597 hasAuthorship W3204242597A5030314659 @default.
• W3204242597 hasAuthorship W3204242597A5065271933 @default.
• W3204242597 hasAuthorship W3204242597A5074154602 @default.
• W3204242597 hasAuthorship W3204242597A5088438048 @default.
• W3204242597 hasBestOaLocation W32042425971 @default.
• W3204242597 hasConcept C109650736 @default.
• W3204242597 hasConcept C111113717 @default.
• W3204242597 hasConcept C112705442 @default.
• W3204242597 hasConcept C126322002 @default.
• W3204242597 hasConcept C142724271 @default.
• W3204242597 hasConcept C204787440 @default.
• W3204242597 hasConcept C27081682 @default.
• W3204242597 hasConcept C2777123777 @default.
• W3204242597 hasConcept C2777477808 @default.
• W3204242597 hasConcept C2777965283 @default.
• W3204242597 hasConcept C2780930544 @default.
• W3204242597 hasConcept C2781210498 @default.
• W3204242597 hasConcept C42407357 @default.
• W3204242597 hasConcept C526171541 @default.
• W3204242597 hasConcept C62231903 @default.
• W3204242597 hasConcept C71924100 @default.
• W3204242597 hasConcept C98274493 @default.
• W3204242597 hasConceptScore W3204242597C109650736 @default.
• W3204242597 hasConceptScore W3204242597C111113717 @default.
• W3204242597 hasConceptScore W3204242597C112705442 @default.
• W3204242597 hasConceptScore W3204242597C126322002 @default.
• W3204242597 hasConceptScore W3204242597C142724271 @default.
• W3204242597 hasConceptScore W3204242597C204787440 @default.
• W3204242597 hasConceptScore W3204242597C27081682 @default.
• W3204242597 hasConceptScore W3204242597C2777123777 @default.
• W3204242597 hasConceptScore W3204242597C2777477808 @default.
• W3204242597 hasConceptScore W3204242597C2777965283 @default.
• W3204242597 hasConceptScore W3204242597C2780930544 @default.
• W3204242597 hasConceptScore W3204242597C2781210498 @default.
• W3204242597 hasConceptScore W3204242597C42407357 @default.
• W3204242597 hasConceptScore W3204242597C526171541 @default.
• W3204242597 hasConceptScore W3204242597C62231903 @default.
• W3204242597 hasConceptScore W3204242597C71924100 @default.
• W3204242597 hasConceptScore W3204242597C98274493 @default.

• next