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- W3204247449 abstract "Programmed cell death (PCD) is a highly regulated process that results in the orderly destruction of a cell. Many different forms of PCD may be distinguished, including apoptosis, PARthanatos, and cGMP-dependent cell death. Misregulation of PCD mechanisms may be the underlying cause of neurodegenerative diseases of the retina, including hereditary retinal degeneration (RD). RD relates to a group of diseases that affect photoreceptors and that are triggered by gene mutations that are often well known nowadays. Nevertheless, the cellular mechanisms of PCD triggered by disease-causing mutations are still poorly understood, and RD is mostly still untreatable. While investigations into the neurodegenerative mechanisms of RD have focused on apoptosis in the past two decades, recent evidence suggests a predominance of non-apoptotic processes as causative mechanisms. Research into these mechanisms carries the hope that the knowledge created can eventually be used to design targeted treatments to prevent photoreceptor loss. Hence, in this review, we summarize studies on PCD in RD, including on apoptosis, PARthanatos, and cGMP-dependent cell death. Then, we focus on a possible interplay between these mechanisms, covering cGMP-signaling targets, overactivation of poly(ADP-ribose)polymerase (PARP), energy depletion, Ca2+-permeable channels, and Ca2+-dependent proteases. Finally, an outlook is given into how specific features of cGMP-signaling and PARthanatos may be targeted by therapeutic interventions." @default.
- W3204247449 created "2021-10-11" @default.
- W3204247449 creator A5004773755 @default.
- W3204247449 creator A5034505842 @default.
- W3204247449 creator A5060064141 @default.
- W3204247449 creator A5065372602 @default.
- W3204247449 date "2021-09-29" @default.
- W3204247449 modified "2023-10-16" @default.
- W3204247449 title "Programmed Non-Apoptotic Cell Death in Hereditary Retinal Degeneration: Crosstalk between cGMP-Dependent Pathways and PARthanatos?" @default.
- W3204247449 cites W1484451637 @default.
- W3204247449 cites W1484931598 @default.
- W3204247449 cites W1504661786 @default.
- W3204247449 cites W150998259 @default.
- W3204247449 cites W1555812953 @default.
- W3204247449 cites W1602155299 @default.
- W3204247449 cites W1607531254 @default.
- W3204247449 cites W161500901 @default.
- W3204247449 cites W1816896904 @default.
- W3204247449 cites W1889509997 @default.
- W3204247449 cites W1964253397 @default.
- W3204247449 cites W1964341586 @default.
- W3204247449 cites W1964836954 @default.
- W3204247449 cites W1965185652 @default.
- W3204247449 cites W1965566484 @default.
- W3204247449 cites W1976881265 @default.
- W3204247449 cites W1978070679 @default.
- W3204247449 cites W1979122673 @default.
- W3204247449 cites W1984046437 @default.
- W3204247449 cites W1985074609 @default.
- W3204247449 cites W1988232847 @default.
- W3204247449 cites W1989433038 @default.
- W3204247449 cites W1989678684 @default.
- W3204247449 cites W1992397774 @default.
- W3204247449 cites W1992652011 @default.
- W3204247449 cites W1994958067 @default.
- W3204247449 cites W1995279525 @default.
- W3204247449 cites W1995320806 @default.
- W3204247449 cites W1998079454 @default.
- W3204247449 cites W1998841108 @default.
- W3204247449 cites W2000080307 @default.
- W3204247449 cites W2000227815 @default.
- W3204247449 cites W2005380010 @default.
- W3204247449 cites W2005458257 @default.
- W3204247449 cites W2008068105 @default.
- W3204247449 cites W2013513647 @default.
- W3204247449 cites W2013969500 @default.
- W3204247449 cites W2014150894 @default.
- W3204247449 cites W2014300705 @default.
- W3204247449 cites W2025223906 @default.
- W3204247449 cites W2025368485 @default.
- W3204247449 cites W2026544879 @default.
- W3204247449 cites W2028803712 @default.
- W3204247449 cites W2029657491 @default.
- W3204247449 cites W2030561559 @default.
- W3204247449 cites W2032995646 @default.
- W3204247449 cites W2033004300 @default.
- W3204247449 cites W2036010602 @default.
- W3204247449 cites W2038990610 @default.
- W3204247449 cites W2040714144 @default.
- W3204247449 cites W2047230408 @default.
- W3204247449 cites W2047809719 @default.
- W3204247449 cites W2048313278 @default.
- W3204247449 cites W2049028195 @default.
- W3204247449 cites W2052853635 @default.
- W3204247449 cites W2055956513 @default.
- W3204247449 cites W2057706543 @default.
- W3204247449 cites W2059397580 @default.
- W3204247449 cites W2063043584 @default.
- W3204247449 cites W2063170114 @default.
- W3204247449 cites W2064463813 @default.
- W3204247449 cites W2067477337 @default.
- W3204247449 cites W2072554501 @default.
- W3204247449 cites W2077274995 @default.
- W3204247449 cites W2077799422 @default.
- W3204247449 cites W2078316306 @default.
- W3204247449 cites W2081736956 @default.
- W3204247449 cites W2083234732 @default.
- W3204247449 cites W2090057285 @default.
- W3204247449 cites W2092780659 @default.
- W3204247449 cites W2096701787 @default.
- W3204247449 cites W2102322990 @default.
- W3204247449 cites W2102560754 @default.
- W3204247449 cites W2105129317 @default.
- W3204247449 cites W2106478568 @default.
- W3204247449 cites W2106789249 @default.
- W3204247449 cites W2111993777 @default.
- W3204247449 cites W2113585002 @default.
- W3204247449 cites W2117049355 @default.
- W3204247449 cites W2131117641 @default.
- W3204247449 cites W2142913230 @default.
- W3204247449 cites W2143952717 @default.
- W3204247449 cites W2151213561 @default.
- W3204247449 cites W2156253346 @default.
- W3204247449 cites W2160544862 @default.
- W3204247449 cites W2163589838 @default.
- W3204247449 cites W2169018657 @default.
- W3204247449 cites W2169436026 @default.
- W3204247449 cites W2176431604 @default.