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• W3204248214 abstract "Primary biliary cholangitis (PBC) diagnosis is based on international criteria, which requires two of the following: (i) elevated alkaline phosphatase (AP), (ii) anti-mitochondrial antibody (AMA) and (iii) liver biopsy (BX) suggestive of PBC. It is still unclear if patients diagnosed by different criteria combinations present peculiarities, especially in highly-admixed populations. To investigate if patients diagnosed with PBC by different combinations of validated criteria present clinical or laboratory particularities. The Brazilian Cholestasis Study Group database was reviewed to compare clinical, biochemical and histological characteristics of PBC between four groups diagnosed by: (1) AP ≥2x upper limit of normality (ULN) + presence of AMA, (2) AP ≥2x ULN + BX suggestive of PBC, (3) presence of AMA + BX suggestive of PBC and (4) all criteria. 482 patients with PBC were included (Table 1). Group-1 presented with higher levels of IgG, lower frequency of arterial hypertension (AH) and lower response to ursodeoxycholic acid (UDCA), while Group-2 had lower: age at diagnosis and HDL-C levels. Group-3 had higher: age at diagnosis, frequency of neoplasms, AH and response to UDCA; and lower: frequency of pruritus and jaundice, levels of aminotransferases, GGT and bilirubin, advanced liver disease and esophageal varices. Group-4 showed higher frequency of symptoms at presentation, especially pruritus. PBC patients diagnosed by different combinations of established criteria may present singular features that can possibly impact in disease presentation and progression." @default.
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• W3204248214 date "2021-09-01" @default.
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• W3204248214 title "O-10 PRIMARY BILIARY CHOLANGITIS PATIENTS DIAGNOSED BY DIFFERENT COMBINATIONS OF THE DIAGNOSTIC CRITERIA PRESENT CLINICAL AND LABORATORY PECULIARITIES" @default.
• W3204248214 doi "https://doi.org/10.1016/j.aohep.2021.100497" @default.
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