FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204254769> ?p ?o ?g. }

• W3204254769 endingPage "121" @default.
• W3204254769 startingPage "112" @default.
• W3204254769 abstract "FAM83H is essential for amelogenesis, but recent reports implicate that FAM83H is involved in the tumorigenesis. We previously clarified that TRIM29 binds to FAM83H to regulate keratin distribution and squamous cell migration. However, little is known about FAM83H in normal/malignant skin keratinocytes.To investigate the expression of FAM83H in cutaneous squamous cell carcinoma (SCC) and its physiological function.Immunohistochemical analysis and RT-PCR of human SCC tissues were performed. Next, we examined the effect of FAM83H knockdown/overexpression in SCC cell lines using cell proliferation, migration, and invasion assay. To investigate the molecular mechanism, immunoprecipitation of FAM83H was examined. Further, Immunofluorescence staining was performed. Finally, we examined the correlation between the expressions of FAM83H and the keratin distribution.FAM83H expression was lower in SCC lesions than in normal epidermis and correlated with differentiation grade. The mRNA expression levels of FAM83H in SCC tumors were also lower than in normal epidermis. The knockdown of FAM83H enhanced SCC cell migration and invasion, whereas the overexpression of FAM83H led to decreases in both. Furthermore, the knockdown of FAM83H enhanced the cancer cell metastasis in vivo. FAM83H formed a complex with TRIM29 and keratins. The knockdown of FAM83H altered keratin distribution and solubility. Clinically, the loss of FAM83H correlates with an altered keratin distribution.Our findings reveal a critical function for FAM83H in regulating keratin distribution, as well as in the migration/invasion of cutaneous SCC, suggesting that FAM83H could be a crucial molecule in the tumorigenesis of cutaneous SCC." @default.
• W3204254769 created "2021-10-11" @default.
• W3204254769 creator A5005371127 @default.
• W3204254769 creator A5012358867 @default.
• W3204254769 creator A5053914726 @default.
• W3204254769 creator A5055656478 @default.
• W3204254769 creator A5057784648 @default.
• W3204254769 creator A5062212787 @default.
• W3204254769 creator A5067879929 @default.
• W3204254769 creator A5068374303 @default.
• W3204254769 creator A5080981463 @default.
• W3204254769 date "2021-11-01" @default.
• W3204254769 modified "2023-10-16" @default.
• W3204254769 title "Loss of FAM83H promotes cell migration and invasion in cutaneous squamous cell carcinoma via impaired keratin distribution" @default.
• W3204254769 cites W1931772900 @default.
• W3204254769 cites W1971140102 @default.
• W3204254769 cites W1994737139 @default.
• W3204254769 cites W2003689405 @default.
• W3204254769 cites W2014476767 @default.
• W3204254769 cites W2023572311 @default.
• W3204254769 cites W2029887457 @default.
• W3204254769 cites W2036235654 @default.
• W3204254769 cites W2057784301 @default.
• W3204254769 cites W2063770721 @default.
• W3204254769 cites W2069964885 @default.
• W3204254769 cites W2081504673 @default.
• W3204254769 cites W2114235916 @default.
• W3204254769 cites W2118379843 @default.
• W3204254769 cites W2124112422 @default.
• W3204254769 cites W2142265048 @default.
• W3204254769 cites W2143043320 @default.
• W3204254769 cites W2143464311 @default.
• W3204254769 cites W2167898988 @default.
• W3204254769 cites W2171810389 @default.
• W3204254769 cites W2395174057 @default.
• W3204254769 cites W2551668581 @default.
• W3204254769 cites W2744131837 @default.
• W3204254769 cites W2744229987 @default.
• W3204254769 cites W2791548959 @default.
• W3204254769 cites W2809608179 @default.
• W3204254769 cites W2898829371 @default.
• W3204254769 cites W2902531676 @default.
• W3204254769 cites W3038002620 @default.
• W3204254769 cites W3046028057 @default.
• W3204254769 cites W4236909101 @default.
• W3204254769 cites W4367590705 @default.
• W3204254769 doi "https://doi.org/10.1016/j.jdermsci.2021.09.007" @default.
• W3204254769 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34657752" @default.
• W3204254769 hasPublicationYear "2021" @default.
• W3204254769 type Work @default.
• W3204254769 sameAs 3204254769 @default.
• W3204254769 citedByCount "6" @default.
• W3204254769 countsByYear W32042547692021 @default.
• W3204254769 countsByYear W32042547692022 @default.
• W3204254769 countsByYear W32042547692023 @default.
• W3204254769 crossrefType "journal-article" @default.
• W3204254769 hasAuthorship W3204254769A5005371127 @default.
• W3204254769 hasAuthorship W3204254769A5012358867 @default.
• W3204254769 hasAuthorship W3204254769A5053914726 @default.
• W3204254769 hasAuthorship W3204254769A5055656478 @default.
• W3204254769 hasAuthorship W3204254769A5057784648 @default.
• W3204254769 hasAuthorship W3204254769A5062212787 @default.
• W3204254769 hasAuthorship W3204254769A5067879929 @default.
• W3204254769 hasAuthorship W3204254769A5068374303 @default.
• W3204254769 hasAuthorship W3204254769A5080981463 @default.
• W3204254769 hasBestOaLocation W32042547691 @default.
• W3204254769 hasConcept C102230213 @default.
• W3204254769 hasConcept C104317684 @default.
• W3204254769 hasConcept C105702510 @default.
• W3204254769 hasConcept C121608353 @default.
• W3204254769 hasConcept C137738243 @default.
• W3204254769 hasConcept C141035611 @default.
• W3204254769 hasConcept C1491633281 @default.
• W3204254769 hasConcept C151730666 @default.
• W3204254769 hasConcept C173396325 @default.
• W3204254769 hasConcept C2776458125 @default.
• W3204254769 hasConcept C2778266373 @default.
• W3204254769 hasConcept C502942594 @default.
• W3204254769 hasConcept C50548948 @default.
• W3204254769 hasConcept C54355233 @default.
• W3204254769 hasConcept C55493867 @default.
• W3204254769 hasConcept C555283112 @default.
• W3204254769 hasConcept C81241287 @default.
• W3204254769 hasConcept C81885089 @default.
• W3204254769 hasConcept C86803240 @default.
• W3204254769 hasConcept C95444343 @default.
• W3204254769 hasConceptScore W3204254769C102230213 @default.
• W3204254769 hasConceptScore W3204254769C104317684 @default.
• W3204254769 hasConceptScore W3204254769C105702510 @default.
• W3204254769 hasConceptScore W3204254769C121608353 @default.
• W3204254769 hasConceptScore W3204254769C137738243 @default.
• W3204254769 hasConceptScore W3204254769C141035611 @default.
• W3204254769 hasConceptScore W3204254769C1491633281 @default.
• W3204254769 hasConceptScore W3204254769C151730666 @default.
• W3204254769 hasConceptScore W3204254769C173396325 @default.
• W3204254769 hasConceptScore W3204254769C2776458125 @default.
• W3204254769 hasConceptScore W3204254769C2778266373 @default.
• W3204254769 hasConceptScore W3204254769C502942594 @default.

• next