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• W3204256293 abstract "Abstract One of the most important topics in molecular biology is the genetic stability of DNA. One threat to this stability is proton transfer along the hydrogen bonds of DNA that could lead to tautomerisation, hence creating point mutations. We present a theoretical analysis of the hydrogen bonds between the Guanine-Cytosine (G-C) nucleotide, which includes an accurate model of the structure of the base pairs, the quantum dynamics of the hydrogen bond proton, and the influence of the decoherent and dissipative cellular environment. We determine that the quantum tunnelling contribution to the proton transfer rate is several orders of magnitude larger than the classical over-the-barrier hopping. Due to the significance of the quantum tunnelling even at biological temperatures, we find that the canonical and tautomeric forms of G-C inter-convert over timescales far shorter than biological ones and hence thermal equilibrium is rapidly reached. Furthermore, we find a large tautomeric occupation probability of 1.73 × 10 −4 , suggesting that such proton transfer may well play a far more important role in DNA mutation than has hitherto been suggested. Our results could have far-reaching consequences for current models of genetic mutations." @default.
• W3204256293 created "2021-10-11" @default.
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• W3204256293 date "2022-05-05" @default.
• W3204256293 modified "2023-10-10" @default.
• W3204256293 title "An open quantum systems approach to proton tunnelling in DNA" @default.
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• W3204256293 doi "https://doi.org/10.1038/s42005-022-00881-8" @default.
• W3204256293 hasPublicationYear "2022" @default.
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