Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204258265> ?p ?o ?g. }
- W3204258265 endingPage "71" @default.
- W3204258265 startingPage "59" @default.
- W3204258265 abstract "Stem cell therapy is a novel therapy being explored for AD. The molecular mechanism of its effect is still unclear. The authors investigated the effects and mechanism by injection of SHEDs into an AD mouse model.SHEDs were cultured in vitro and injected into AD SAMP8 mice by caudal vein, and SHEDs labeled via synthetic dye showed in vivo migration to the head. The cognitive ability of SAMP8 mice was evaluated via Barnes maze and new object recognition. The pathological indicators of AD, including Tau, amyloid plaques and inflammatory factors, were examined at the protein or RNA level. Next, macro-proteomics analysis and weighted gene co-expression network analysis (WGCNA) based on protein groups and behavioral data were applied to discover the important gene cluster involved in the improvement of AD by SHEDs, which was further confirmed in an AD model in both mouse and cell lines.SHED treatment improved the cognitive ability and pathological symptoms of SAMP8 mice. Proteomics analysis indicated that these improvements were tightly related to the mitochondria, which was proved through examination of the shape and function of mitochondria both in vivo (SAMP8 brain) and in vitro (SH-SY5Y cells). Finally, the core targets of SHEDs in the mitochondrial pathway, Hook3, Mic13 and MIF, were screened out and confirmed in vivo.SHED treatment significantly relieved AD symptoms, improved cognitive ability and reversed memory loss in an AD mouse model, possibly through the recovery of dysfunctional mitochondria. These results raise the possibility that SHED may ease the symptoms of AD by targeting the mitochondria." @default.
- W3204258265 created "2021-10-11" @default.
- W3204258265 creator A5003751132 @default.
- W3204258265 creator A5006506036 @default.
- W3204258265 creator A5013582226 @default.
- W3204258265 creator A5016675554 @default.
- W3204258265 creator A5031306837 @default.
- W3204258265 creator A5033656715 @default.
- W3204258265 creator A5041751929 @default.
- W3204258265 creator A5045654970 @default.
- W3204258265 creator A5072949609 @default.
- W3204258265 creator A5073492643 @default.
- W3204258265 creator A5080133364 @default.
- W3204258265 creator A5083289428 @default.
- W3204258265 date "2022-01-01" @default.
- W3204258265 modified "2023-10-01" @default.
- W3204258265 title "Stem cells from human exfoliated deciduous teeth affect mitochondria and reverse cognitive decline in a senescence-accelerated mouse prone 8 model" @default.
- W3204258265 cites W1966327575 @default.
- W3204258265 cites W1969690844 @default.
- W3204258265 cites W1978813419 @default.
- W3204258265 cites W1993160420 @default.
- W3204258265 cites W2001665323 @default.
- W3204258265 cites W2006909664 @default.
- W3204258265 cites W2023855839 @default.
- W3204258265 cites W2037915750 @default.
- W3204258265 cites W2045060921 @default.
- W3204258265 cites W2056012419 @default.
- W3204258265 cites W2057545775 @default.
- W3204258265 cites W2059005775 @default.
- W3204258265 cites W2062628622 @default.
- W3204258265 cites W2071276938 @default.
- W3204258265 cites W2078533736 @default.
- W3204258265 cites W2079749054 @default.
- W3204258265 cites W2088297214 @default.
- W3204258265 cites W2101898118 @default.
- W3204258265 cites W2102992354 @default.
- W3204258265 cites W2103440561 @default.
- W3204258265 cites W2107376426 @default.
- W3204258265 cites W2108386295 @default.
- W3204258265 cites W2112184383 @default.
- W3204258265 cites W2115437022 @default.
- W3204258265 cites W2115574704 @default.
- W3204258265 cites W2116864112 @default.
- W3204258265 cites W2141282621 @default.
- W3204258265 cites W2143238511 @default.
- W3204258265 cites W2151015629 @default.
- W3204258265 cites W2155142785 @default.
- W3204258265 cites W2159266328 @default.
- W3204258265 cites W2162686830 @default.
- W3204258265 cites W2163757074 @default.
- W3204258265 cites W2165427528 @default.
- W3204258265 cites W2200229144 @default.
- W3204258265 cites W2201402669 @default.
- W3204258265 cites W2254436645 @default.
- W3204258265 cites W2272687938 @default.
- W3204258265 cites W2335262420 @default.
- W3204258265 cites W2345349101 @default.
- W3204258265 cites W2346645422 @default.
- W3204258265 cites W2490579634 @default.
- W3204258265 cites W2593605425 @default.
- W3204258265 cites W2624778884 @default.
- W3204258265 cites W2731887704 @default.
- W3204258265 cites W2803005522 @default.
- W3204258265 cites W2811324451 @default.
- W3204258265 cites W2845880205 @default.
- W3204258265 cites W2907547898 @default.
- W3204258265 cites W2911493122 @default.
- W3204258265 cites W2913440408 @default.
- W3204258265 cites W2944106486 @default.
- W3204258265 cites W2948651404 @default.
- W3204258265 cites W2950046916 @default.
- W3204258265 cites W2950249001 @default.
- W3204258265 cites W2962834367 @default.
- W3204258265 cites W2965158785 @default.
- W3204258265 cites W2991485014 @default.
- W3204258265 cites W3049429138 @default.
- W3204258265 cites W3087432842 @default.
- W3204258265 cites W3096241805 @default.
- W3204258265 cites W3122324184 @default.
- W3204258265 doi "https://doi.org/10.1016/j.jcyt.2021.07.018" @default.
- W3204258265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34598900" @default.
- W3204258265 hasPublicationYear "2022" @default.
- W3204258265 type Work @default.
- W3204258265 sameAs 3204258265 @default.
- W3204258265 citedByCount "4" @default.
- W3204258265 countsByYear W32042582652022 @default.
- W3204258265 countsByYear W32042582652023 @default.
- W3204258265 crossrefType "journal-article" @default.
- W3204258265 hasAuthorship W3204258265A5003751132 @default.
- W3204258265 hasAuthorship W3204258265A5006506036 @default.
- W3204258265 hasAuthorship W3204258265A5013582226 @default.
- W3204258265 hasAuthorship W3204258265A5016675554 @default.
- W3204258265 hasAuthorship W3204258265A5031306837 @default.
- W3204258265 hasAuthorship W3204258265A5033656715 @default.
- W3204258265 hasAuthorship W3204258265A5041751929 @default.
- W3204258265 hasAuthorship W3204258265A5045654970 @default.
- W3204258265 hasAuthorship W3204258265A5072949609 @default.
- W3204258265 hasAuthorship W3204258265A5073492643 @default.