FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204260081> ?p ?o ?g. }

• W3204260081 abstract "Abstract The processes by which pathogens evolve within single hosts dictate the efficacy of treatment strategies designed to slow antibiotic resistance evolution and influence the population-wide resistance levels. The aim of this study is to describe the underlying genetic and phenotypic changes leading to antibiotic resistance within a single patient who died as resistance evolved to available antibiotics. We assess whether robust patterns of collateral sensitivity and response to combinations exist that might have been leveraged to improve therapy. Whole-genome sequencing was completed for nine isolates taken from this patient over 279 days of chronic infection with Enterobacter hormaechei , along with systematic measurements of changes in resistance against five of the most relevant drugs considered for treatment. The entirety of the genetic change is consistent with de novo mutations and plasmid loss events, without the acquisition of foreign genetic material via horizontal gene transfer. The isolates formed three genetically distinct lineages, with early evolutionary trajectories being supplanted by previously unobserved multi-step evolutionary trajectories. Importantly, no single isolate evolved resistance to all of the antibiotics considered for treatment against E. hormaechei ( i . e ., none was pan-resistant). Patterns of collateral sensitivity and response to combination therapy revealed contrasting patterns across this diversifying population. Translating antibiotic resistance management strategies from theoretical and laboratory data to clinical situations, such as this, may require managing diverse populations with unpredictable resistance trajectories." @default.
• W3204260081 created "2021-10-11" @default.
• W3204260081 creator A5025937223 @default.
• W3204260081 creator A5033174278 @default.
• W3204260081 creator A5036017069 @default.
• W3204260081 creator A5067627826 @default.
• W3204260081 creator A5068761878 @default.
• W3204260081 creator A5077441742 @default.
• W3204260081 date "2021-10-07" @default.
• W3204260081 modified "2023-09-26" @default.
• W3204260081 title "Genetic determinants of antibiotic resistance and the evolution of trade-offs during adaptation in a single patient" @default.
• W3204260081 cites W1829159316 @default.
• W3204260081 cites W193556419 @default.
• W3204260081 cites W1943327251 @default.
• W3204260081 cites W1970168814 @default.
• W3204260081 cites W1977222141 @default.
• W3204260081 cites W1983042430 @default.
• W3204260081 cites W1990788636 @default.
• W3204260081 cites W1997251834 @default.
• W3204260081 cites W1998499425 @default.
• W3204260081 cites W1998611924 @default.
• W3204260081 cites W2003930774 @default.
• W3204260081 cites W2030847176 @default.
• W3204260081 cites W2034243251 @default.
• W3204260081 cites W2036121975 @default.
• W3204260081 cites W2038432877 @default.
• W3204260081 cites W2077572900 @default.
• W3204260081 cites W2080777238 @default.
• W3204260081 cites W2092505971 @default.
• W3204260081 cites W2097226393 @default.
• W3204260081 cites W2097432034 @default.
• W3204260081 cites W2097910397 @default.
• W3204260081 cites W2099185129 @default.
• W3204260081 cites W2099303284 @default.
• W3204260081 cites W2108234281 @default.
• W3204260081 cites W2111539591 @default.
• W3204260081 cites W2112833584 @default.
• W3204260081 cites W2112885344 @default.
• W3204260081 cites W2128726449 @default.
• W3204260081 cites W2130403968 @default.
• W3204260081 cites W2133878623 @default.
• W3204260081 cites W2141900882 @default.
• W3204260081 cites W2144969488 @default.
• W3204260081 cites W2146370523 @default.
• W3204260081 cites W2148054572 @default.
• W3204260081 cites W2148134634 @default.
• W3204260081 cites W2148689162 @default.
• W3204260081 cites W2154239872 @default.
• W3204260081 cites W2156293023 @default.
• W3204260081 cites W2162632787 @default.
• W3204260081 cites W2163217206 @default.
• W3204260081 cites W2168610085 @default.
• W3204260081 cites W2171332813 @default.
• W3204260081 cites W2171535756 @default.
• W3204260081 cites W2175745890 @default.
• W3204260081 cites W2202810729 @default.
• W3204260081 cites W2222642144 @default.
• W3204260081 cites W2346538456 @default.
• W3204260081 cites W2400710517 @default.
• W3204260081 cites W2586526737 @default.
• W3204260081 cites W2617633297 @default.
• W3204260081 cites W2782393048 @default.
• W3204260081 cites W2800472347 @default.
• W3204260081 cites W2803637930 @default.
• W3204260081 cites W2810134141 @default.
• W3204260081 cites W2936662929 @default.
• W3204260081 cites W2950354111 @default.
• W3204260081 cites W2982049202 @default.
• W3204260081 cites W2982357988 @default.
• W3204260081 cites W2990355714 @default.
• W3204260081 cites W3039544099 @default.
• W3204260081 cites W4247053599 @default.
• W3204260081 cites W56353252 @default.
• W3204260081 doi "https://doi.org/10.1101/2021.10.06.463321" @default.
• W3204260081 hasPublicationYear "2021" @default.
• W3204260081 type Work @default.
• W3204260081 sameAs 3204260081 @default.
• W3204260081 citedByCount "0" @default.
• W3204260081 crossrefType "posted-content" @default.
• W3204260081 hasAuthorship W3204260081A5025937223 @default.
• W3204260081 hasAuthorship W3204260081A5033174278 @default.
• W3204260081 hasAuthorship W3204260081A5036017069 @default.
• W3204260081 hasAuthorship W3204260081A5067627826 @default.
• W3204260081 hasAuthorship W3204260081A5068761878 @default.
• W3204260081 hasAuthorship W3204260081A5077441742 @default.
• W3204260081 hasBestOaLocation W32042600811 @default.
• W3204260081 hasConcept C104317684 @default.
• W3204260081 hasConcept C139807058 @default.
• W3204260081 hasConcept C141231307 @default.
• W3204260081 hasConcept C144024400 @default.
• W3204260081 hasConcept C169760540 @default.
• W3204260081 hasConcept C18903297 @default.
• W3204260081 hasConcept C22744801 @default.
• W3204260081 hasConcept C2908647359 @default.
• W3204260081 hasConcept C2993632694 @default.
• W3204260081 hasConcept C501593827 @default.
• W3204260081 hasConcept C54355233 @default.
• W3204260081 hasConcept C57473165 @default.
• W3204260081 hasConcept C71924100 @default.
• W3204260081 hasConcept C73484699 @default.

• next