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• W3204264340 abstract "Inspired by allosteric regulation of natural molecules, we present a rational design scheme to build synthetic nucleic acid allosteric nanodevices. The clearly specified conformational states of switches obtained from systematic screening and analyses make the ON-OFF transition clear-cut and quantification ready. Under the rational design scheme, we have developed a series of DNA switches with triplex-forming oligos as allosteric modulators and implemented designated allosteric transitions, allosteric coregulation, and reaction pathway control. In conjunction with toehold-mediated strand displacement, our design scheme has also been applied to synthetic nucleic acid computing including a set of logic operations and complex algorithm." @default.
• W3204264340 created "2021-10-11" @default.
• W3204264340 creator A5035571303 @default.
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• W3204264340 date "2021-10-04" @default.
• W3204264340 modified "2023-10-02" @default.
• W3204264340 title "Rational Design of Allosteric Nanodevices Based on DNA Triple Helix" @default.
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• W3204264340 doi "https://doi.org/10.1021/jacs.1c07824" @default.
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