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- W3204268210 endingPage "3204" @default.
- W3204268210 startingPage "3192" @default.
- W3204268210 abstract "Cell therapies based on reprogrammed adaptive immune cells have great potential as living drugs. As first demonstrated clinically for engineered chimeric antigen receptor (CAR) T cells, the ability of such cells to undergo clonal expansion in response to an antigen promotes both self-renewal and self-regulation in vivo. B cells also have the potential to be developed as immune cell therapies, but engineering their specificity and functionality is more challenging than for T cells. In part, this is due to the complexity of the immunoglobulin (Ig) locus, as well as the requirement for regulated expression of both cell surface B cell receptor and secreted antibody isoforms, in order to fully recapitulate the features of natural antibody production. Recent advances in genome editing are now allowing reprogramming of B cells by site-specific engineering of the Ig locus with preformed antibodies. In this review, we discuss the potential of engineered B cells as a cell therapy, the challenges involved in editing the Ig locus and the advances that are making this possible, and envision future directions for this emerging field of immune cell engineering." @default.
- W3204268210 created "2021-10-11" @default.
- W3204268210 creator A5019108137 @default.
- W3204268210 creator A5032868413 @default.
- W3204268210 date "2021-11-01" @default.
- W3204268210 modified "2023-10-15" @default.
- W3204268210 title "Genome edited B cells: a new frontier in immune cell therapies" @default.
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