FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204269586> ?p ?o ?g. }

• W3204269586 abstract "During pathogenic infections, bacterial cells experience environmental stress conditions, including low oxygen and thermal stress. Bacterial cells proliferate during infection and divide by a mechanism characterized by the assembly of a large cytoskeletal structure at the division site called the Z-ring. The major protein constituting the Z-ring is FtsZ, a tubulin homolog and GTPase that utilizes the nucleotide to assemble into dynamic polymers. In Escherichia coli, many cell division proteins interact with FtsZ and modulate Z-ring assembly, while others direct cell wall insertion and peptidoglycan remodeling. Here, we show that ZapE, an ATPase that accumulates during late constriction, directly interacts with FtsZ and phospholipids in vitro. In the presence of adenosine triphosphate (ATP), ZapE induces bundling of GTP-induced FtsZ polymers; however, ZapE also binds FtsZ in the absence of GTP. The ZapE mutant protein ZapE(K84A), which is defective for ATP hydrolysis, also interacts with FtsZ and induces FtsZ filament bundling. In vivo, cultures of zapE deletion cells contain a low percentage of filamentous cells, suggesting that they have a modest division defect; however, they are able to grow when exposed to stress, such as high temperature and limited oxygen. When combined with the chromosomal deletion of minC, which encodes an FtsZ disassembly factor, ΔzapE ΔminC cells experience growth delays that slow proliferation at high temperature and prevent recovery. This synthetic slow growth phenotype after exposure to stress suggests that ZapE may function to ensure proliferation during and after stress, and this is exacerbated when cells are also deleted for minC. Expression of either ZapE or ZapE(K84A) complements the aberrant growth phenotypes in vivo suggesting that the division-associated role of ZapE does not require ZapE ATP hydrolysis. These results support that ZapE is a stress-regulated cell division protein that interacts directly with FtsZ and phospholipids, promoting growth and division after exposure to environmental stress." @default.
• W3204269586 created "2021-10-11" @default.
• W3204269586 creator A5035245597 @default.
• W3204269586 creator A5042187359 @default.
• W3204269586 creator A5059079968 @default.
• W3204269586 creator A5061543166 @default.
• W3204269586 creator A5084964270 @default.
• W3204269586 creator A5086898961 @default.
• W3204269586 date "2021-09-27" @default.
• W3204269586 modified "2023-10-02" @default.
• W3204269586 title "The Stress-Active Cell Division Protein ZapE Alters FtsZ Filament Architecture to Facilitate Division in Escherichia coli" @default.
• W3204269586 cites W1483637431 @default.
• W3204269586 cites W1541921455 @default.
• W3204269586 cites W1547143002 @default.
• W3204269586 cites W1714832738 @default.
• W3204269586 cites W1767329992 @default.
• W3204269586 cites W1941109656 @default.
• W3204269586 cites W1964601681 @default.
• W3204269586 cites W1967936154 @default.
• W3204269586 cites W1970870025 @default.
• W3204269586 cites W1990033090 @default.
• W3204269586 cites W2000214816 @default.
• W3204269586 cites W2014966950 @default.
• W3204269586 cites W2032705779 @default.
• W3204269586 cites W2043173692 @default.
• W3204269586 cites W2045721146 @default.
• W3204269586 cites W2050025536 @default.
• W3204269586 cites W2050251519 @default.
• W3204269586 cites W2050887062 @default.
• W3204269586 cites W2052800057 @default.
• W3204269586 cites W2059377906 @default.
• W3204269586 cites W2069087157 @default.
• W3204269586 cites W2069602560 @default.
• W3204269586 cites W2070067221 @default.
• W3204269586 cites W2073229143 @default.
• W3204269586 cites W2077350233 @default.
• W3204269586 cites W2110743190 @default.
• W3204269586 cites W2111496441 @default.
• W3204269586 cites W2113818747 @default.
• W3204269586 cites W2114427530 @default.
• W3204269586 cites W2114750851 @default.
• W3204269586 cites W2116137883 @default.
• W3204269586 cites W2117941118 @default.
• W3204269586 cites W2118755520 @default.
• W3204269586 cites W2123183721 @default.
• W3204269586 cites W2134153749 @default.
• W3204269586 cites W2138853444 @default.
• W3204269586 cites W2142779706 @default.
• W3204269586 cites W2143254124 @default.
• W3204269586 cites W2151801929 @default.
• W3204269586 cites W2155785063 @default.
• W3204269586 cites W2157831032 @default.
• W3204269586 cites W2162494237 @default.
• W3204269586 cites W2166926472 @default.
• W3204269586 cites W2170009635 @default.
• W3204269586 cites W2463992938 @default.
• W3204269586 cites W2576709265 @default.
• W3204269586 cites W2580107622 @default.
• W3204269586 cites W2611002955 @default.
• W3204269586 cites W2779046686 @default.
• W3204269586 cites W2883693924 @default.
• W3204269586 cites W2896448427 @default.
• W3204269586 cites W2901017822 @default.
• W3204269586 cites W2948453868 @default.
• W3204269586 cites W2948716905 @default.
• W3204269586 cites W2996451414 @default.
• W3204269586 doi "https://doi.org/10.3389/fmicb.2021.733085" @default.
• W3204269586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8503651" @default.
• W3204269586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34646253" @default.
• W3204269586 hasPublicationYear "2021" @default.
• W3204269586 type Work @default.
• W3204269586 sameAs 3204269586 @default.
• W3204269586 citedByCount "4" @default.
• W3204269586 countsByYear W32042695862022 @default.
• W3204269586 countsByYear W32042695862023 @default.
• W3204269586 crossrefType "journal-article" @default.
• W3204269586 hasAuthorship W3204269586A5035245597 @default.
• W3204269586 hasAuthorship W3204269586A5042187359 @default.
• W3204269586 hasAuthorship W3204269586A5059079968 @default.
• W3204269586 hasAuthorship W3204269586A5061543166 @default.
• W3204269586 hasAuthorship W3204269586A5084964270 @default.
• W3204269586 hasAuthorship W3204269586A5086898961 @default.
• W3204269586 hasBestOaLocation W32042695861 @default.
• W3204269586 hasConcept C104317684 @default.
• W3204269586 hasConcept C125235067 @default.
• W3204269586 hasConcept C142669718 @default.
• W3204269586 hasConcept C143065580 @default.
• W3204269586 hasConcept C1491633281 @default.
• W3204269586 hasConcept C20418707 @default.
• W3204269586 hasConcept C207332259 @default.
• W3204269586 hasConcept C2776237524 @default.
• W3204269586 hasConcept C2776634448 @default.
• W3204269586 hasConcept C55493867 @default.
• W3204269586 hasConcept C62551211 @default.
• W3204269586 hasConcept C84425145 @default.
• W3204269586 hasConcept C85813293 @default.
• W3204269586 hasConcept C86803240 @default.
• W3204269586 hasConcept C95444343 @default.
• W3204269586 hasConceptScore W3204269586C104317684 @default.
• W3204269586 hasConceptScore W3204269586C125235067 @default.

• next