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- W3204270735 endingPage "10328" @default.
- W3204270735 startingPage "10328" @default.
- W3204270735 abstract "Genomic studies have identified some of the most relevant genetic players in Neuroendocrine Neoplasm (NEN) tumorigenesis. However, we are still far from being able to draw a model that encompasses their heterogeneity, elucidates the different biological effects consequent to the identified molecular events, or incorporates extensive knowledge of molecular biomarkers and therapeutic targets. Here, we reviewed recent insights in NEN tumorigenesis from selected basic research studies on animal models, highlighting novel players in the intergenic cooperation and peculiar mechanisms including splicing dysregulation, chromatin stability, or cell dedifferentiation. Furthermore, models of tumorigenesis based on composite interactions other than a linear progression of events are proposed, exemplified by the involvement in NEN tumorigenesis of genes regulating complex functions, such as MEN1 or DAXX. Although limited by interspecies differences, animal models have proved helpful for the more in-depth study of every facet of tumorigenesis, showing that the identification of driver mutations is only one of the many necessary steps and that other mechanisms are worth investigating." @default.
- W3204270735 created "2021-10-11" @default.
- W3204270735 creator A5004158910 @default.
- W3204270735 creator A5025473720 @default.
- W3204270735 creator A5036052073 @default.
- W3204270735 creator A5039295056 @default.
- W3204270735 creator A5053034134 @default.
- W3204270735 date "2021-09-25" @default.
- W3204270735 modified "2023-09-29" @default.
- W3204270735 title "Insights into Mechanisms of Tumorigenesis in Neuroendocrine Neoplasms" @default.
- W3204270735 cites W1484020898 @default.
- W3204270735 cites W1502590013 @default.
- W3204270735 cites W1793067559 @default.
- W3204270735 cites W1835922716 @default.
- W3204270735 cites W1883773314 @default.
- W3204270735 cites W1978154786 @default.
- W3204270735 cites W1980937575 @default.
- W3204270735 cites W1981695027 @default.
- W3204270735 cites W1983489516 @default.
- W3204270735 cites W1992715434 @default.
- W3204270735 cites W1998137598 @default.
- W3204270735 cites W1998392635 @default.
- W3204270735 cites W2002500034 @default.
- W3204270735 cites W2005250386 @default.
- W3204270735 cites W2009778100 @default.
- W3204270735 cites W2013875083 @default.
- W3204270735 cites W2013974230 @default.
- W3204270735 cites W2015188570 @default.
- W3204270735 cites W2015683443 @default.
- W3204270735 cites W2034842280 @default.
- W3204270735 cites W2036681136 @default.
- W3204270735 cites W2037003692 @default.
- W3204270735 cites W2047355421 @default.
- W3204270735 cites W2047664934 @default.
- W3204270735 cites W2049628139 @default.
- W3204270735 cites W2050146183 @default.
- W3204270735 cites W2051819196 @default.
- W3204270735 cites W2057781965 @default.
- W3204270735 cites W2077507001 @default.
- W3204270735 cites W2086013297 @default.
- W3204270735 cites W2091799578 @default.
- W3204270735 cites W2094799740 @default.
- W3204270735 cites W2116229314 @default.
- W3204270735 cites W2119492915 @default.
- W3204270735 cites W2140185624 @default.
- W3204270735 cites W2142747205 @default.
- W3204270735 cites W2150212366 @default.
- W3204270735 cites W2151926428 @default.
- W3204270735 cites W2155447119 @default.
- W3204270735 cites W2161409973 @default.
- W3204270735 cites W2172279754 @default.
- W3204270735 cites W2196075541 @default.
- W3204270735 cites W2208793511 @default.
- W3204270735 cites W2234094683 @default.
- W3204270735 cites W2290138226 @default.
- W3204270735 cites W2295391127 @default.
- W3204270735 cites W2361464748 @default.
- W3204270735 cites W2472255748 @default.
- W3204270735 cites W2490812923 @default.
- W3204270735 cites W2567956911 @default.
- W3204270735 cites W2589112207 @default.
- W3204270735 cites W2592270240 @default.
- W3204270735 cites W2600375888 @default.
- W3204270735 cites W2606513998 @default.
- W3204270735 cites W2608160487 @default.
- W3204270735 cites W2613422246 @default.
- W3204270735 cites W2623594410 @default.
- W3204270735 cites W2740582701 @default.
- W3204270735 cites W2766264211 @default.
- W3204270735 cites W2767161732 @default.
- W3204270735 cites W2782615459 @default.
- W3204270735 cites W2789377322 @default.
- W3204270735 cites W2808435931 @default.
- W3204270735 cites W2810843460 @default.
- W3204270735 cites W2890029692 @default.
- W3204270735 cites W2891044561 @default.
- W3204270735 cites W2896744886 @default.
- W3204270735 cites W2896987809 @default.
- W3204270735 cites W2899330895 @default.
- W3204270735 cites W2903602033 @default.
- W3204270735 cites W2910804142 @default.
- W3204270735 cites W2921068301 @default.
- W3204270735 cites W2921269539 @default.
- W3204270735 cites W2922353426 @default.
- W3204270735 cites W2923405593 @default.
- W3204270735 cites W2939318105 @default.
- W3204270735 cites W2945144547 @default.
- W3204270735 cites W2948658169 @default.
- W3204270735 cites W2952011786 @default.
- W3204270735 cites W2953909528 @default.
- W3204270735 cites W2955129730 @default.
- W3204270735 cites W2976870398 @default.
- W3204270735 cites W3010398944 @default.
- W3204270735 cites W3012353851 @default.
- W3204270735 cites W3014981954 @default.
- W3204270735 cites W3015547645 @default.
- W3204270735 cites W3027721570 @default.
- W3204270735 cites W3033469690 @default.