Matches in SemOpenAlex for { <https://semopenalex.org/work/W3204274666> ?p ?o ?g. }
- W3204274666 endingPage "497" @default.
- W3204274666 startingPage "481" @default.
- W3204274666 abstract "Trimethyltin chloride (TMT) is a stabilizer for polyvinyl chloride plastics that causes serious health hazards in nontarget organisms. Melatonin (MT) exhibits powerful protective effects in cardiac diseases. As a new environmental pollutant, TMT-induced cardiotoxicity and the protective effects of MT remain unclear. To explore this, the mice were treated with TMT (2.8 mg/kg) and/or MT (10 mg/kg) for 7 days. Firstly, the histopathological and ultrastructural evaluation showed that TMT induced cardiac damage, tumescent rupture and nuclear pyknosis. Moreover, TMT elevated the expressions of pyroptosis genes NLRP3, ASC and Cas1 and inflammation factors IL-6, IL-17 and TNFα. Secondly, TMT reduced antioxidant enzymes (GSH, CAT and T-AOC) via decreasing the expression of genes associated with the Keap1-Nrf2/ARE pathway to increase oxidative stress. Thirdly, TMT decreased the expression of genes associated with the ARE-driven drug metabolizing enzymes (DMEs), including Akr7a3, Akr1b8, and Akr1b10. Besides, TMT upregulated the mRNA expression of nuclear Xenobiotic metabolism on cytochrome P450s enzymes via increasing the expression of CAR, PXP, and AHR genes. Furthermore, MT treatment mitigated the aforementioned adverse changes induced by TMT. Overall, these results demonstrated that TMT caused pyroptosis and inflammation to aggravate cardiac damage via inducing excessive oxidative stress, imbalance of DMEs homeostasis, and nuclear Xenobiotic metabolism disorder, which could be alleviated by MT." @default.
- W3204274666 created "2021-10-11" @default.
- W3204274666 creator A5011922035 @default.
- W3204274666 creator A5014929343 @default.
- W3204274666 creator A5045907730 @default.
- W3204274666 creator A5064527448 @default.
- W3204274666 creator A5077323251 @default.
- W3204274666 creator A5085028455 @default.
- W3204274666 creator A5085460763 @default.
- W3204274666 date "2021-09-27" @default.
- W3204274666 modified "2023-10-09" @default.
- W3204274666 title "Melatonin ameliorates trimethyltin chloride‐induced cardiotoxicity: The role of nuclear xenobiotic metabolism and <scp>Keap1‐Nrf2</scp>/<scp>ARE</scp> axis‐mediated pyroptosis" @default.
- W3204274666 cites W1985970823 @default.
- W3204274666 cites W1990815185 @default.
- W3204274666 cites W2010347552 @default.
- W3204274666 cites W2044600859 @default.
- W3204274666 cites W2056975261 @default.
- W3204274666 cites W2061157014 @default.
- W3204274666 cites W2070871702 @default.
- W3204274666 cites W2072031294 @default.
- W3204274666 cites W2147653980 @default.
- W3204274666 cites W2152084279 @default.
- W3204274666 cites W2157013090 @default.
- W3204274666 cites W2196442069 @default.
- W3204274666 cites W2206238007 @default.
- W3204274666 cites W2591103711 @default.
- W3204274666 cites W2612697984 @default.
- W3204274666 cites W2748095317 @default.
- W3204274666 cites W2763311421 @default.
- W3204274666 cites W2794350096 @default.
- W3204274666 cites W2807588107 @default.
- W3204274666 cites W2884445384 @default.
- W3204274666 cites W2889422847 @default.
- W3204274666 cites W2892098973 @default.
- W3204274666 cites W2896455688 @default.
- W3204274666 cites W2898339267 @default.
- W3204274666 cites W2903878804 @default.
- W3204274666 cites W2904552328 @default.
- W3204274666 cites W2939562813 @default.
- W3204274666 cites W2941324044 @default.
- W3204274666 cites W2946057803 @default.
- W3204274666 cites W2951801120 @default.
- W3204274666 cites W2963590191 @default.
- W3204274666 cites W2968232536 @default.
- W3204274666 cites W2968519908 @default.
- W3204274666 cites W2968949810 @default.
- W3204274666 cites W2971843315 @default.
- W3204274666 cites W2972646730 @default.
- W3204274666 cites W2973003320 @default.
- W3204274666 cites W2989852004 @default.
- W3204274666 cites W2996531062 @default.
- W3204274666 cites W2997070176 @default.
- W3204274666 cites W2999797487 @default.
- W3204274666 cites W3000506725 @default.
- W3204274666 cites W3024179740 @default.
- W3204274666 cites W3035428849 @default.
- W3204274666 cites W3049544551 @default.
- W3204274666 cites W3058036789 @default.
- W3204274666 cites W3130095331 @default.
- W3204274666 cites W3130533053 @default.
- W3204274666 cites W3138246523 @default.
- W3204274666 cites W3160473494 @default.
- W3204274666 cites W3175402526 @default.
- W3204274666 cites W3186229379 @default.
- W3204274666 doi "https://doi.org/10.1002/biof.1787" @default.
- W3204274666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34570919" @default.
- W3204274666 hasPublicationYear "2021" @default.
- W3204274666 type Work @default.
- W3204274666 sameAs 3204274666 @default.
- W3204274666 citedByCount "10" @default.
- W3204274666 countsByYear W32042746662021 @default.
- W3204274666 countsByYear W32042746662022 @default.
- W3204274666 countsByYear W32042746662023 @default.
- W3204274666 crossrefType "journal-article" @default.
- W3204274666 hasAuthorship W3204274666A5011922035 @default.
- W3204274666 hasAuthorship W3204274666A5014929343 @default.
- W3204274666 hasAuthorship W3204274666A5045907730 @default.
- W3204274666 hasAuthorship W3204274666A5064527448 @default.
- W3204274666 hasAuthorship W3204274666A5077323251 @default.
- W3204274666 hasAuthorship W3204274666A5085028455 @default.
- W3204274666 hasAuthorship W3204274666A5085460763 @default.
- W3204274666 hasConcept C104317684 @default.
- W3204274666 hasConcept C126322002 @default.
- W3204274666 hasConcept C178790620 @default.
- W3204274666 hasConcept C185592680 @default.
- W3204274666 hasConcept C2776151105 @default.
- W3204274666 hasConcept C2776529522 @default.
- W3204274666 hasConcept C2776914184 @default.
- W3204274666 hasConcept C2778233292 @default.
- W3204274666 hasConcept C29730261 @default.
- W3204274666 hasConcept C55493867 @default.
- W3204274666 hasConcept C71924100 @default.
- W3204274666 hasConcept C86339819 @default.
- W3204274666 hasConcept C98274493 @default.
- W3204274666 hasConceptScore W3204274666C104317684 @default.
- W3204274666 hasConceptScore W3204274666C126322002 @default.
- W3204274666 hasConceptScore W3204274666C178790620 @default.
- W3204274666 hasConceptScore W3204274666C185592680 @default.